Model Based Prediction Approach for Internal Machine Tool Heat Sources on the Level of Subsystems

AbstractModern machine tools are highly sophisticated mechatronic systems. Each subsystem's energy efficiency is important regarding thermal effects of the machine: Losses in the subsystems are mainly heat sources, causing temperature gradients and thermal elongation. Knowledge about the internal heat sources is therefore mandatory for high precision machining, as well as for the design of compensation strategies. This paper presents a modeling approach to estimate the heat release of machine tool subsystems and predict boundary conditions for thermal models. The simulation results are verified by measurements on an internal cooling system of a lathe.Video abstrac

Field responsive mechanical metamaterials.

Typically, mechanical metamaterial properties are programmed and set when the architecture is designed and constructed, and do not change in response to shifting environmental conditions or application requirements. We present a new class of architected materials called field responsive mechanical metamaterials (FRMMs) that exhibit dynamic control and on-the-fly tunability enabled by careful design and selection of both material composition and architecture. To demonstrate the FRMM concept, we print complex structures composed of polymeric tubes infilled with magnetorheological fluid suspensions. Modulating remotely applied magnetic fields results in rapid, reversible, and sizable changes of the effective stiffness of our metamaterial motifs

Respiratory Management of Patients with ALS in Northern New England

Background: • Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease, is a progressive neurodegenerative disease caused by the degeneration of brain and spinal cord motor neurons, leading to steady loss of voluntary muscle function and early death from respiratory failure. •The incidence of ALS is 1?2/100,000 population, the prevalence is 5?6/100,000 and approximately 30,000 people are living with ALS in the United States. • Currently there is no cure for ALS; treatment is focused on symptomatic care and improving the quality of life. • Most ALS patients in the United States are treated either at multidisciplinary ALS centers/clinics in academic institutions or by community?based physicians/ neurology practices. • It is unclear if outcomes in patients with ALS are different among those followed in multidisciplinary clinics(MDC) versus community based physicians/ neurology practices (CP). • The goal of this project was to compare the type of respiratory education and care received by patients with ALS from Northern New England at MDC’s (Fletcher Allen and Dartmouth Medical Center) versus CP.https://scholarworks.uvm.edu/comphp_gallery/1029/thumbnail.jp

El valor diagnóstico de la beta2 microglobulina en la enfermedad renal.

The World Health Organization defines kidney disease or kidney failure as the gradual loss of physiological functioning of the kidneys because these patients require timely treatment for subsequent monitoring and control, by determining Beta2- Microglobulin it is possible to obtain clinical data on renal status. The objective of this article was to investigate the diagnostic value of beta2 microglobulin in kidney disease, using a documentary and descriptive design; The information gathering was possible through the review of electronic databases such as PubMed, Medigraphic, ScienceDirect, Cochrane, Scielo and Elsevier. As main results, it was evidenced that the renal alterations of prevalence were acute and chronic renal failure between 7.1 and 66.6%, thrombotic microangiopathy with 2.3% and acute tubular necrosis with 2.3%; the risk factors associated with renal compromise correspond to age over 50 years, male gender and comorbidities such as diabetes mellitus, arterial hypertension, coronary diseases and cerebrovascular accidents; Finally, the predominant complications were atherosclerosis, diabetic nephropathy, retinopathy, renal osteodystrophy, and amyloidosis. It is concluded that B2 microglobulin is a true indicator of kidney injury and the development of research on this subject in the national context is suggested.La Organización Mundial de la salud define como enfermedad renal o insuficiencia renal a la pérdida gradual del funcionamiento fisiológico de los riñones, debido a que dichos pacientes requieren de un tratamiento oportuno para su posterior seguimiento y control, mediante la determinación de Beta2-Microglobulina es posible obtener datos clínicos sobre el estado renal. El objetivo del presente artículo fue investigar el valor diagnóstico de beta2 microglobulina en la enfermedad renal, empleando un diseño documental y descriptivo; el levantamiento de información fue posible a través de la revisión de bases de datos electrónicas como PubMed, Medigraphic, ScienceDirect, Cochrane, Scielo y Elsevier. Como principales resultados se evidenció que las alteraciones renales de prevalencia fueron insuficiencia renal aguda y crónica entre 7,1 a 66,6%, microangiopatía trombótica con 2,3% y necrosis tubular aguda con 2,3%; los factores de riesgo asociados al compromiso renal, corresponden a la edad mayor a 50 años, género masculino y comorbilidades como diabetes mellitus, hipertensión arterial, enfermedades coronarias y accidentes cerebrovasculares; por último, las complicaciones predominantes fue la aterosclerosis, nefropatía diabética, retinopatía, osteodistrofia renal y amiloidosis. Se concluye que la B2 microglobulina constituye un verdadero indicador de lesión renal y se sugiere el desarrollo de investigaciones sobre esta temática en el contexto nacional.&nbsp

Análisis del Clima Laboral y la Satisfacción de los Empleados en una Empresa de Consultoría en Ecuador

The study on the Work Environment and Employee Satisfaction in a Consulting Company in Ecuador aimed to address a central problem that affects both operational efficiency as well as the well-being of the organization. Therefore, it focuses on salary dissatisfaction, lack of clarity in career development opportunities, promoting collaboration and internal communication as areas of concern. To achieve this, three research methods were used: documentary, which is based on the analysis of internal documents and employment contracts; the statistician, who collected quantitative data through surveys and questionnaires; and the phonological, which used interviews in order to explore the experiences of employees. Finally, the results highlight salary dissatisfaction as a critical problem, along with the lack of clarity in professional development opportunities, the promotion of collaboration, poor internal communication and lack of recognition contributing to employee dissatisfaction. Considering these findings reveal that these areas need essential improvement to strengthen employee well-being and the success of the company in a highly competitive consulting market.El estudio sobre el Clima Laboral y la Satisfacción de los Empleados en una Empresa de Consultoría en Ecuador tuvo como objetivo abordar un problema central que afecta tanto la eficiencia operativa, así como el bienestar de la organización. Por lo tanto, se enfoca en la insatisfacción salarial, la falta de claridad en las oportunidades de desarrollo profesional, la promoción de la colaboración y la comunicación interna como áreas de preocupación. Para lograr esto, se emplearon tres métodos de investigación: el documental, que se basa en el análisis de documentos internos y contratos laborales; el estadístico, que recopiló datos cuantitativos a través de encuestas y cuestionarios; y el fonológico, que utilizó entrevistas con la finalidad de explorar las experiencias de los empleados. Finalmente, los resultados destacan la insatisfacción salarial como un problema crítico, junto con la falta de claridad en las oportunidades de desarrollo profesional, la promoción de la colaboración, la comunicación interna deficiente y la falta de reconocimiento aportando a la insatisfacción de los empleados. Considerando estos hallazgos revelan que dichas áreas necesitan de una mejora esencial para fortalecer el bienestar de los empleados y así como el éxito de la empresa en un mercado de consultoría altamente competitivo

Global Disease Burden Estimates of Respiratory Syncytial Virus–Associated Acute Respiratory Infection in Older Adults in 2015::A Systematic Review and Meta-Analysis

Respiratory syncytial virus associated acute respiratory infection (RSV-ARI)constitutes a substantial disease burden in older adults≥65 years. We aimed to identify all studies worldwide investigating the disease burden ofRSV-ARIin this population. We estimated thecommunityincidence, hospitalisationrate and in-hospital case fatality ratio (hCFR) of RSV-ARI in older adults stratified by industrialized anddeveloping regions, with data from a systematic review ofstudies published between January 1996 and April 2018, and from 8 unpublished population-based studies. We applied these rate estimates to population estimates for 2015, to calculate the global and regional burdenin older adults with RSV-ARIin community and in hospital duringthat year. We estimated thenumber ofin-hospital RSV-ARIdeaths by combining hCFR with hospital admission estimates from hospital-based studies. In 2015, there were about 1.5million(95% CI 0.3-6.9) episodes of RSV-ARIin older adults in41industrialised countries (data missing in developing countries), and of these 214,000 (~14.5%; 95% CI 100,000-459,000) were admitted to hospitals. The global number of hospital admissionsforRSV-ARI in older adults was estimated at 336,000 (UR 186,000-614,000).We further estimated about 14,000 (UR 5,000-50,000) in-hospital deaths related to RSV-ARIglobally.The hospital admission rate and hCFR were higher for those ≥65 years than those aged 50-64 years. The disease burden of RSV-ARIamong older adults is substantialwith limited data from developing countries; appropriate prevention and management strategiesare needed to reduce this burden