Charged Current Anti-Neutrino Interactions in the ND280 Detector

For the neutrino beamline oscillation experiment Tokai to Kamioka, the beam is clas-si ed before oscillation by the near detector complex. The detector is used to measure the ux of di erent particles through the detector, and compare them to Monte Carlo Simulations. For this work, the νµ background of the detector was isolated by examining the Monte Carlo simulation and determining cuts which removed unwanted particles. Then, a selection of the data from the near detector complex underwent the same cuts, and compared to the Monte Carlo to determine if the Monte Carlo represented the data distribution accurately. The data was found to be consistent with the Monte Carlo Simulation

A Guide to Missouri\u27s Freshwater Mussels

https://bearworks.missouristate.edu/books/1017/thumbnail.jp

Prospectus, October 24, 2019

APO PLANS ANNUAL PENNIES FOR PUMPKINS; Costume Shop Provides Last-minute Halloween Ideas; Students Reveal Halloween Traditions & Superstitions; Annual U of I Homecoming Parade: A Long-lasting Tradition; A teacher, creator, and mentor of theatre; Fall festivities anyone?; History of the holiday: What is Halloween?https://spark.parkland.edu/prospectus_2019/1046/thumbnail.jp

Prospectus, November 21, 2019

BOARD APPROVES $509,850 DESIGN PHASE; Meet the staff: Nicoline Hansen, Digital Editor; Stress less with Stress Less Week; ESL resources available in Champaign-Urbana; Dine and Discuss: Issues impacting veterans; ISA and Queen\u27s Organization Participates in Fashion Shoot; This Week in History: JFK’s demise — What happened?; Catch Parkland’s rendition of Peter and The Starcatcher; WPCD presents fall 2019 radio dramashttps://spark.parkland.edu/prospectus_2019/1050/thumbnail.jp

Streamlining T cell engager development with a diverse panel of fully human CD3-binding antibodies, bispecific engineering technology, and an integrated discovery engine

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From nanoliter to large-scale bioreactors: How integrated technologies bring antibody treatments to patients faster

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Positron Emission Tomography Imaging of CD105 Expression with a 64Cu-Labeled Monoclonal Antibody: NOTA Is Superior to DOTA

Optimizing the in vivo stability of positron emission tomography (PET) tracers is of critical importance to cancer diagnosis. In the case of 64Cu-labeled monoclonal antibodies (mAb), in vivo behavior and biodistribution is critically dependent on the performance of the bifunctional chelator used to conjugate the mAb to the radiolabel. This study compared the in vivo characteristics of 64Cu-labeled TRC105 (a chimeric mAb that binds to both human and murine CD105), through two commonly used chelators: 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA). Flow cytometry analysis confirmed that chelator conjugation of TRC105 did not affect its CD105 binding affinity or specificity. PET imaging and biodistribution studies in 4T1 murine breast tumor-bearing mice revealed that 64Cu-NOTA-TRC105 exhibited better stability than 64Cu-DOTA-TRC105 in vivo, which resulted in significantly lower liver uptake without compromising the tumor targeting efficiency. In conclusion, this study confirmed that NOTA is a superior chelator to DOTA for PET imaging with 64Cu-labeled TRC105

Nitric oxide synthases and tubal ectopic pregnancies induced by Chlamydia infection: basic and clinical insights

Human ectopic pregnancy (EP) remains a common cause of pregnancy-related first trimester death. Nitric oxide (NO) is synthesized from L-arginine by three NO synthases (NOS) in different tissues, including the Fallopian tube. Studies of knockout mouse models have improved our understanding of the function of NOS isoforms in reproduction, but their roles and specific mechanisms in infection-induced tubal dysfunction have not been fully elucidated. Here, we provide an overview of the expression, regulation and possible function of NOS isoforms in the Fallopian tube, highlighting the effects of infection-induced changes in the tubal cellular microenvironment (imbalance of NO production) on tubal dysfunction and the potential involvement of NOS isoforms in tubal EP after Chlamydia trachomatis genital infection. The non-equivalent regulation of tubal NOS isoforms during the menstrual cycle suggests that endogenous ovarian steroid hormones regulate NOS in an isoform-specific manner. The current literature suggests that infection with C. trachomatis induces an inflammatory response that eventually leads to tubal epithelial destruction and functional impairment, caused by a high NO output mediated by inducible NOS (iNOS). Therefore, tissue-specific therapeutic approaches to suppress iNOS expression may help to prevent ectopic implantation in patients with prior C. trachomatis infection of the Fallopian tube