Cosmic Texture from a Broken Global SU(3) Symmetry

We investigate the observable consequences of creating cosmic texture by breaking a global SU(3) symmetry, rather than the SU(2) case which is generally studied. To this end, we study the nonlinear sigma model for a totally broken SU(3) symmetry, and develop a technique for numerically solving the classical field equations. This technique is applied in a cosmological context: the energy of the collapsing SU(3) texture field is used as a gravitational source for the production of perturbations in the primordial fluids of the early universe. From these calculations, we make predictions about the appearance of the anisotropies in the cosmic microwave background radiation (CMBR) which would be present if the large scale structure of the universe was gravitationally seeded by the collapse of SU(3) textures.Comment: 28 pages, latex, 11 figures, submitted to Phys. Rev.

In vivo nuclear magnetic resonance imaging

A number of physiological changes have been demonstrated in bone, muscle and blood after exposure of humans and animals to microgravity. Determining mechanisms and the development of effective countermeasures for long duration space missions is an important NASA goal. The advent of tomographic nuclear magnetic resonance imaging (NMR or MRI) gives NASA a way to greatly extend early studies of this phenomena in ways not previously possible; NMR is also noninvasive and safe. NMR provides both superb anatomical images for volume assessments of individual organs and quantification of chemical/physical changes induced in the examined tissues. The feasibility of NMR as a tool for human physiological research as it is affected by microgravity is demonstrated. The animal studies employed the rear limb suspended rat as a model of mucle atrophy that results from microgravity. And bedrest of normal male subjects was used to simulate the effects of microgravity on bone and muscle

Flexibility in the receptor-binding domain of the enzymatic colicin E9 is required for toxicity against Escherichia coli cells

The events that occur after the binding of the enzymatic E colicins to Escherichia coli BtuB receptors that lead to translocation of the cytotoxic domain into the periplasmic space and, ultimately, cell killing are poorly understood. It has been suggested that unfolding of the coiled-coil Mull receptor binding domain of the E colicins may be an essential step that leads to the loss of immunity protein from the colicin and immunity protein complex and then triggers the events of translocation. We introduced pairs of cysteine mutations into the receptor binding domain of colicin E9 (ColE9) that resulted in the formation of a disulfide bond located near the middle or the top of the R domain. After dithiothreitol reduction, the ColE9 protein with the mutations L359C and F412C (ColE9 L359C-F412C) and the ColE9 protein with the mutations Y324C and L447C (ColE9 Y324C-L447C) were slightly less active than equivalent concentrations of ColE9. On oxidation with diamide, no significant biological activity was seen with the ColE9 L359C-F412C and the ColE9 Y324C-L447C mutant proteins; however diamide had no effect on the activity of ColE9. The presence of a disulfide bond was confirmed in both of the oxidized, mutant proteins by matrix-assisted laser desorption ionization-time of flight mass spectrometry. The loss of biological activity of the disulfide-containing mutant proteins was not due to an indirect effect on the properties of the translocation or DNase domains of the mutant colicins. The data are consistent with a requirement for the flexibility of the coiled-coil R domain after binding to BtuB

United States Food Law Update: Health Care Reform, Preemption, Labeling Claims and Unpaid Interns: The Latest Battles in Food Law

This edition of the Food Law Update explores four legal issues arising in the first half of 2010 reflective of the diverse nature of the food law specialist. As the national debate surrounding the merits of health care reform dominated the legislative agenda, this article first will discuss the food labeling rules embedded within section 4205 of the Patient Protection and Affordable Care Act of 2010. The authors then analyze the preemptive reach of the Federal Food, Drug, and Cosmetic Act and the Meat Inspection Act with respect to three separate California statutes regarding animal welfare standards, retail labels on meat packages and state-based mislabeling claims for natural products. Section three further discusses litigation concerning allegedly misleading label claims of health benefits, nutritional composition, natural foods and Country-of-Origin. The final section of this Update explores an increasingly important legal issue common in the local foods/small scale production content - the use of unpaid interns as labor and potential changes in regulatory oversight

Cosmological Simulations of the Preheating Scenario for Galaxy Cluster Formation: Comparison to Analytic Models and Observations

We perform a set of non--radiative cosmological simulations of a preheated intracluster medium in which the entropy of the gas was uniformly boosted at high redshift. The results of these simulations are used first to test the current analytic techniques of preheating via entropy input in the smooth accretion limit. When the unmodified profile is taken directly from simulations, we find that this model is in excellent agreement with the results of our simulations. This suggests that preheated efficiently smoothes the accreted gas, and therefore a shift in the unmodified profile is a good approximation even with a realistic accretion history. When we examine the simulation results in detail, we do not find strong evidence for entropy amplification, at least for the high-redshift preheating model adopted here. In the second section of the paper, we compare the results of the preheating simulations to recent observations. We show -- in agreement with previous work -- that for a reasonable amount of preheating, a satisfactory match can be found to the mass-temperature and luminosity-temperature relations. However -- as noted by previous authors -- we find that the entropy profiles of the simulated groups are much too flat compared to observations. In particular, while rich clusters converge on the adiabatic self--similar scaling at large radius, no single value of the entropy input during preheating can simultaneously reproduce both the core and outer entropy levels. As a result, we confirm that the simple preheating scenario for galaxy cluster formation, in which entropy is injected universally at high redshift, is inconsistent with observations.Comment: 11 pages, 13 figures, accepted for publication in Ap

Nonlinear Outcome of Gravitational Instability in Disks with Realistic Cooling

We consider the nonlinear outcome of gravitational instability in optically thick disks with a realistic cooling function. We use a numerical model that is local, razor-thin, and unmagnetized. External illumination is ignored. Cooling is calculated from a one-zone model using analytic fits to low temperature Rosseland mean opacities. The model has two parameters: the initial surface density Sigma_0 and the rotation frequency Omega. We survey the parameter space and find: (1) The disk fragments when t_c,eff Omega = 1, where t_c,eff is an effective cooling time defined as the average internal energy of the model divided by the average cooling rate. This is consistent with earlier results that used a simplified cooling function. (2) The initial cooling time t_c0 or a uniform disk with Q = 1 can differ by orders of magnitude from t_c,eff in the nonlinear outcome. The difference is caused by sharp variations in the opacity with temperature. The condition t_c0 Omega = 1 therefore does not necessarily indicate where fragmentation will occur. (3) The largest difference between t_c,eff and t_c0 is near the opacity gap, where dust is absent and hydrogen is largely molecular. (4) In the limit of strong illumination the disk is isothermal; we find that an isothermal version of our model fragments for Q < 1.4. Finally, we discuss some physical processes not included in our model, and find that most are likely to make disks more susceptible to fragmentation. We conclude that disks with t_c,eff Omega < 1 do not exist.Comment: 30 pages, 12 figure

Scale-invariance in gravity and implications for the cosmological constant

Recently a scale invariant theory of gravity was constructed by imposing a conformal symmetry on general relativity. The imposition of this symmetry changed the configuration space from superspace - the space of all Riemannian 3-metrics modulo diffeomorphisms - to conformal superspace - the space of all Riemannian 3-metrics modulo diffeomorphisms and conformal transformations. However, despite numerous attractive features, the theory suffers from at least one major problem: the volume of the universe is no longer a dynamical variable. In attempting to resolve this problem a new theory is found which has several surprising and atractive features from both quantisation and cosmological perspectives. Furthermore, it is an extremely restrictive theory and thus may provide testable predictions quickly and easily. One particularly interesting feature of the theory is the resolution of the cosmological constant problem.Comment: Replaced with final version: minor changes to text; references adde

Preliminary results of polarization signatures for glacial moraines in the Mono Basin, Eastern Sierra Nevada

The valleys of the Mono Basin contain several sets of lateral and terminal moraines representing multiple stages of glaciation. The semi-arid climate with slow weathering rates preserved sequences of nested younger moraines within older ones. There is a well established relative chronology and recently exposure dating provided a new set of numerical dates. The moraines span the late Wisconsin (11-25 ka) to the Illinoian (130-190 ka) glaciations. The Mono Basin area was used as a 'calibration site' to establish remote dating techniques for eventual transfer to the more inaccessible but geomorphically and climatically similar moraines of the South American Andes Mountains. Planned polarimetric synthetic aperture radar (SAR) imagery acquired by JPL AIRSAR (South American Campaign) and SIR-C (Andes super-site) are analyzed to establish chronologies of previously undated moraine sequences in a study of Pleistocene climatic change in the Southern Hemisphere. The dry climate and sparse vegetation is also favorable for correlation of ground surface roughness with radar polarization signature. The slow weathering processes acting over thousands of years reduce the size, frequency, and angularity of surface boulders while increasing soil development on the moraines. Field observations based on this hypothesis result in relative ages consistent with those inferred from nested position within the valley. Younger moraines, therefore, will appear rougher than the older smoother moraines at scales measurable at AIRSAR wavelengths. Previously documented effects of ground surface roughness on polarization signatures suggest that analysis of moraine polarization signatures can be useful for relative dating. The technique may be extended to predict numerical ages. The data set reported were acquired on 8 Sep. 1989 with the JPL Airborne SAR (AIRSAR) collecting polarimetric imagery at C- (5.6 cm), L- (24 cm), and P-band (68 cm) with a flight-line parallel to the strike of the mountains. Phase calibration was performed on the analyzed scene by setting the co-phase of a smooth lake to zero as described. Absolute amplitude calibration was not possible because corner reflectors were not deployed

Synthesis of Unsymmetrical Bis(phosphine) Oxides and Their Phosphines via Secondary Phosphine Oxide Precursors

The unsymmetrical bidentate phosphine ligands (Me)2PCH2CH2CH2P(Et)2 (14), (Me)2PCH2CH2CH2P(iPr)2 (15), (Me)2PCH2CH2CH2P(Cy)2 (16), and (Me)2PCH2CH2CH2P(Ph)2 (17) were synthesized using air–stable phosphine oxide intermediates. In the first step, sodium phosphinites formed by deprotonation of (Me)2P(O)H, (Et)2P(O)H, and (iPr)2P(O)H were alkylated by 1-bromo-3-chloropropane. The different substitution rates of the chloride and bromide groups allowed the isolation of the intermediates (Me)2P(O)CH2CH2CH2Cl (2), (Et)2P(O)CH2CH2CH2Cl (3), and (iPr)2P(O)CH2CH2CH2Cl (4). Subsequent reaction of (Me)2P(O)CH2CH2CH2Cl (2) with the sodium phosphinites generated from (Et)2P(O)H, (iPr)2P(O)H, (tBu)2P(O)H, (Cy)2P(O)H, or (Ph)2P(O)H gave unsymmetrical bidentate phosphine oxides; reduction of these oxides yielded the unsymmetrical phosphines. The unsymmetrical bidentate phosphines react with metal salts to form complexes. X-ray crystal structures of cis-Pt((Me)2P(CH2CH2CH2)P(iPr)2)Cl2 (20) and racemic [CuI((Me)2P(CH2CH2CH2)P(Ph)2)]Cl (21) were obtained. The kinetics and scope of the synthetic route were also explored. Experiments showed that the rate of substitution of the alkyl chloride group in (R)2P(O)CH2CH2CH2Cl-type oxides increases relative to unsubstituted alkyl chlorides due to the presence of the phosphonyl group on one end of the molecule. The scope of the reaction involving 1,2-dihaloalkanes was also investigated, and it was found that the reaction mixture of sodium dimethylphosphinite and 1,2-dihaloalkanes formed tetramethylbis(phosphine) monoxide (22), which decomposes on work-up to give complex reaction mixtures