1,235 research outputs found

    Students’ Models of Magnetic Interactions: A Comparative Analysis of Accurate and Inaccurate Models over a Ten-Year Interval

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    This research investigates the Models of eighth-grade students in Turkey pertaining to magnets and magnetic interactions, while also examining the consistency of these models within themselves. Additionally, a comparative assessment is conducted by comparing the current data with data collected from eighth-grade students a decade earlier. The study comprises 59 students in the first phase and 45 students in the second phase, all of whom briefly received formal instruction on magnetism during fourth grade. The focus of the analysis centers on identifying the students’ Models and evaluating their coherence across diverse contexts in both phases. Surprisingly, despite the passage of ten years, the mental model patterns exhibited by the students in both studies remain remarkably similar. Three primary categories emerged from the students’ Models of magnets, including attraction and repulsion, magnetic poles, and the composition and functionality of magnets. However, noticeable distinctions between the two studies are evident. In the earlier study, the students’ responses to survey questions displayed a greater variety and detail in comparison to the responses from the later study. Moreover, the second study revealed fewer instances of inconsistent Models concerning the magnetic interaction between magnets and nails, but more instances of inaccurate Models compared to the first study. The findings of this investigation offer valuable insights to educators, guiding them in designing effective lessons and activities aimed at helping students overcome their inaccurate and inconsistent Models

    The Future of Citizen Science

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    There is an emerging trend of democratizing science and schooling within science education that can be characterized as citizen science. We explore the roots of this movement and some current projects to underscore the meaning of citizen science in science and schooling. We show that citizen science, as it is currently conceptualized, does not go far enough to resolve the concerns of communities and environments when considered holistically and when compared with more dynamic and multidimensional ideas for characterizing science. We use the examples of colony collapse disorder (CCD) and emerging trends of nanotechnology as cases in point. Then we justify three dialogical spheres of influence for future citizen science. As citizen science becomes more holistic, it embodies the responsibility of youths who are prepared to engage real concerns in their community

    Proceedings of the Ninth Annual Indiana STEM Education Conference: Resourcing STEM Education

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    The Proceedings of the Ninth Annual Indiana STEM Education Conference are edited by the Center for Advancing the Teaching and Learning of STEM (CATALYST, https://www.education.purdue.edu/catalyst/) at Purdue University. The theme for the 2024 conference is Resourcing STEM Education. This year’s Indiana STEM Education Conference provides opportunities to learn about effective STEM education strategies, curriculum, and resources to engage students in integrated STEM learning opportunities and address the recently updated Indiana Academic Standards for Science and Computer Science, Indiana Academic Standards for Mathematics, and Indiana Academic Standards for Integrated STEM (https://www.in.gov/doe/students/indiana-academic-standards/)

    Preface and Acknowledgments

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    Goals and Proceedings Information

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    MicroRNA regulation of bovine monocyte inflammatory and metabolic networks in an in vivo infection model.

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    peer-reviewedBovine mastitis is an inflammation-driven disease of the bovine mammary gland that costs the global dairy industry several billion dollars per annum. Because disease susceptibility is a multi-factorial complex phenotype, an integrative biology approach is required to dissect the molecular networks involved. Here, we report such an approach, using next generation sequencing combined with advanced network and pathway biology methods to simultaneously profile mRNA and miRNA expression at multiple time-points (0, 12, 24, 36 and 48h) in both milk and blood FACS-isolated CD14+ monocytes from animals infected in vivo with Streptococcus uberis. More than 3,700 differentially expressed (DE) genes were identified in milk-isolated monocytes (MIMs), a key immune cell recruited to the site of infection during mastitis. Up-regulated genes were significantly enriched for inflammatory pathways, while down-regulated genes were enriched for non-glycolytic metabolic pathways. Monocyte transcriptional changes in the blood, however, were more subtle but highlighted the impact of this infection systemically. Genes up-regulated in blood-isolated-monocytes (BIMs) showed a significant association with interferon and chemokine signalling. Furthermore, twenty-six miRNAs were differentially expressed in MIMs and three in BIMs. Pathway analysis revealed that predicted targets of down-regulated miRNAs were highly enriched for roles in innate immunity (FDR < 3.4E-8) in particular TLR signalling, while up-regulated miRNAs preferentially targeted genes involved in metabolism. We conclude that during S. uberis infection miRNAs are key amplifiers of monocyte inflammatory response networks and repressors of several metabolic pathways.This study was funded in part by Teagasc RMIS 6018 and United States Department of Agriculture ARS funding 3625-32000-102-00. NL is supported by a Teagasc Walsh Fellowship

    Contents

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    Goals and Proceedings Information

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    Ares I-X Ground Diagnostic Prototype

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    The automation of pre-launch diagnostics for launch vehicles offers three potential benefits: improving safety, reducing cost, and reducing launch delays. The Ares I-X Ground Diagnostic Prototype demonstrated anomaly detection, fault detection, fault isolation, and diagnostics for the Ares I-X first-stage Thrust Vector Control and for the associated ground hydraulics while the vehicle was in the Vehicle Assembly Building at Kennedy Space Center (KSC) and while it was on the launch pad. The prototype combines three existing tools. The first tool, TEAMS (Testability Engineering and Maintenance System), is a model-based tool from Qualtech Systems Inc. for fault isolation and diagnostics. The second tool, SHINE (Spacecraft Health Inference Engine), is a rule-based expert system that was developed at the NASA Jet Propulsion Laboratory. We developed SHINE rules for fault detection and mode identification, and used the outputs of SHINE as inputs to TEAMS. The third tool, IMS (Inductive Monitoring System), is an anomaly detection tool that was developed at NASA Ames Research Center. The three tools were integrated and deployed to KSC, where they were interfaced with live data. This paper describes how the prototype performed during the period of time before the launch, including accuracy and computer resource usage. The paper concludes with some of the lessons that we learned from the experience of developing and deploying the prototype
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