13,049 research outputs found

    The Quantum McKay Correspondence for polyhedral singularities

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    Let G be a polyhedral group, namely a finite subgroup of SO(3). Nakamura's G-Hilbert scheme provides a preferred Calabi-Yau resolution Y of the polyhedral singularity C^3/G. The classical McKay correspondence describes the classical geometry of Y in terms of the representation theory of G. In this paper we describe the quantum geometry of Y in terms of R, an ADE root system associated to G. Namely, we give an explicit formula for the Gromov-Witten partition function of Y as a product over the positive roots of R. In terms of counts of BPS states (Gopakumar-Vafa invariants), our result can be stated as a correspondence: each positive root of R corresponds to one half of a genus zero BPS state. As an application, we use the crepant resolution conjecture to provide a full prediction for the orbifold Gromov-Witten invariants of [C^3/G].Comment: Introduction rewritten. Issue regarding non-uniqueness of conifold resolution clarified. Version to appear in Inventione

    Evidence for the intense exchange of MazG in marine cyanophages by horizontal gene transfer

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    Background: S-PM2 is a phage capable of infecting strains of unicellular cyanobacteria belonging to the genus Synechococcus. S-PM2, like other myoviruses infecting marine cyanobacteria, encodes a number of bacterial-like genes. Amongst these genes is one encoding a MazG homologue that is hypothesized to be involved in the adaption of the infected host for production of progeny phage. Methodology/Principal Findings: This study focuses on establishing the occurrence of mazG homologues in other cyanophages isolated from different oceanic locations. Degenerate PCR primers were designed using the mazG gene of S-PM2. The mazG gene was found to be widely distributed and highly conserved among Synechococcus myoviruses and podoviruses from diverse oceanic provinces. Conclusions/Significance: This study provides evidence of a globally connected cyanophage gene pool, the cyanophage mazG gene having a small effective population size indicative of rapid lateral gene transfer despite being present in a substantial fraction of cyanophage. The Prochlorococcus and Synechococcus phage mazG genes do not cluster with the host mazG gene, suggesting that their primary hosts are not the source of the mazG gene

    Patients' preferences for the management of non-metastatic prostate cancer: discrete choice experiment

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    Objective To establish which attributes of conservative treatments for prostate cancer are most important to men. Design Discrete choice experiment. Setting Two London hospitals. Participants 129 men with non-metastatic prostate cancer, mean age 70 years; 69 of 118 (58%) with T stage 1 or 2 cancer at diagnosis. Main outcome measures Men's preferences for, and trade-offs between, the attributes of diarrhoea, hot flushes, ability to maintain an erection, breast swelling or tenderness, physical energy, sex drive, life expectancy, and out of pocket expenses. Results The men's responses to changes in attributes were all statistically significant. When asked to assume a starting life expectancy of five years, the men were willing to make trade-offs between life expectancy and side effects. On average, they were most willing to give up life expectancy to avoid limitations in physical energy (mean three months) and least willing to trade life expectancy to avoid hot flushes (mean 0.6 months to move from a moderate to mild level or from mild to none). Conclusions Men with prostate cancer are willing to participate in a relatively complex exercise that weighs up the advantages and disadvantages of various conservative treatments for their condition. They were willing to trade off some life expectancy to be relieved of the burden of troublesome side effects such as limitations in physical energy

    The Globular Cluster Luminosity Function and Specific Frequency in Dwarf Elliptical Galaxies

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    The globular cluster luminosity function, specific globular cluster frequency, S_N, specific globular cluster mass, T_MP, and globular cluster mass fraction in dwarf elliptical galaxies are explored using the full 69 galaxy sample of the HST WFPC2 Dwarf Elliptical Galaxy Snapshot Survey. The GCLFs of the dEs are well-represented with a t_5 function with a peak at M_{V,Z}^0(dE,HST) = -7.3 +/- 0.1. This is ~0.3 magnitudes fainter than the GCLF peaks in giant spiral and elliptical galaxies, but the results are consistent within the uncertainties. The bright-end slope of the luminosity distribution has a power-law form with slope alpha = -1.9 +/- 0.1. The trend of increasing S_N or T_MP with decreasing host galaxy luminosity is confirmed. The mean value for T_MP in dE,N galaxies is about a factor of two higher than the mean value for non-nucleated galaxies and the distributions of T_MP in dE,N and dE,noN galaxies are statistically different. These data are combined with results from the literature for a wide range of galaxy types and environments. At low host galaxy masses the distribution of T_MP for dE,noN and dI galaxies are similar. This supports the idea that one pathway for forming dE,noN galaxies is by the stripping of dIs. The formation of nuclei and the larger values of T_MP in dE,N galaxies may be due to higher star formation rates and star cluster formation efficiencies due to interactions in galaxy cluster environments.Comment: 53 pages, 13 figures, 12 tables, accepted by the Astrophysical Journa

    CAD and creativity: does the computer really help?

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    We are frequently told by its exponents that computeraided design (CAD) liberates designers and gives them new ways of envisioning their work, but is this really true? CAD in architecture is examined to see to what extent it has enhanced creativity in design. This is partly done by applying a test of creativity advanced by contemporary architect Herman Hertzberger. In this analysis, CAD is found somewhat wanting, and some suggestions are made as to why this might be so

    China's Ongoing Agricultural Modernization: Challenges Remain After 30 Years of Reform

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    Thirty years ago, China began implementing a series of reforms to improve efficiency in agricultural production. These, and subsequent, reforms reshaped China’s position in the world economy. China’s rapid economic development and transformation from a planned to a market-oriented economy, however, has reached a stage where further efficiency gains in agricultural production will likely hinge on the development of modern market-supporting institutions. The development of market-supporting institutions in China will bring about long-term and sustainable benefits to producers and consumers in China and the global agricultural economy. This report provides an overview of current issues in China’s agricultural development, policy responses to these issues, and the effects of these policies on China’s growing role in international markets.China, economic reform, economic development, agricultural production, agricultural trade, Agricultural and Food Policy, International Relations/Trade, Production Economics,
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