25 research outputs found
The risk of metabolic syndrome as a result of lifestyle among Ellisras rural young adults
The study aimed to investigate the association between metabolic syndrome (MetS) and lifestyle risk
factors among Ellisras
adults. A cross-sectional study was conducted on 624 adults (306 males and 318 females). MetS was
defined according to the criteria of the International Diabetes Federation. The prevalence of MetS
was 23.1% (8.6% males and 36.8 % females). Females appeared to have higher mean values for waist
circumference (WC), fasting blood glucose (FBG), total cholesterol (TCHOL) and low-density
lipoprotein cholesterol (LDL-C), while males had high mean values for high-density lipoprotein
cholesterol (HDL-C), triglycerides (TG), systolic blood pressure (SBP) and diastolic blood pressure
(DBP). No significant age and gender differences were observed for dietary intake. Significantly more
females (51.9%) presented with increased WC than males (4.6%). Participants who had a high dietary
energy intake were significantly less likely to present with larger WC (OR: 0.250 95% CI [0.161;
0.389]), low HDL-C (OR: 0.306 95% CI [0.220; 0.425]) and high LDL-C (OR: 0.583 95%
CI [0.418; 0.812]) but more likely to present with elevated FBG (OR: 1.01 95% CI [0.735; 1.386]),
high TCHOL (OR: 1.039
95% CI [0.575; 1.337]), high TG (OR: 1.186 95% CI [0.695; 2.023]) and hypertension (OR: 5.205 95%
CI [3.156; 8.585]).
After adjusting for age, gender, smoking, and alcohol status, high energy intake was more than two
times likely to predict MetS in adults with a large WC (OR: 2.766 95% CI [0.863; 3.477] and
elevated FBG (OR: 2.227 95% CI [1.051; 3.328]). Therefore, identifying groups that are at an
increased risk and those that are in their early stages of MetS will help improve
and prevent the increase of the MetS in the future
Angiomirs expression profiling in diffuse large B-Cell lymphoma
Despite advances in treatment, 30% of diffuse large B-cell lymphoma (DLBCL) cases are refractory or relapse after chemoimmunotherapy. Currently, the relationship between angiogenesis and angiomiRs in DLBCL is unknown. We classified 84 DLBCL cases according to stromal signatures and evaluated the expression of pro-and antiangiomiRs in paraffin embedded tissues of DLBCL and correlated them with microvascular density (MVD). 40% of cases were classified as stromal-1, 50% as stromal-2 and 10% were not classified. We observed increased expression of proangiomiRs Let-7f, miR-17, miR-18a, miR-19b, miR-126, miR-130a, miR-210, miR-296 and miR-378 in 14%, 57%, 30%, 45%, 12%, 12%, 56%, 58% and 48% of the cases, respectively. Among antiangiomiRs we found decreased expression of miR-16, miR-20b, miR-92a, miR-221 and miR-328 in, respectively, 27%, 71%, 2%, 44% and 11%. We found association between increased expression of proangiomiRs miR-126 and miR-130a and antiangiomiR miR-328 and the subtype non-GCB. We found higher levels of the antiangiomiRs miR-16, miR-221 and miR-328 in patients with low MVD and stromal-1 signature. IPI and CD34 confirmed independent impact on survival of the study group. None of the above angiomiRs showed significance as biomarker in an independent serum samples cohort of patients and controls. In conclusion, we confirmed association between antiangiomiRs miR-16, miR-221 and miR-328 and stromal-1 signature. Four angiomiRs emerged as potential therapeutic targets: proangiomiRs miR-17, miR-210 and miR-296 and antiangiomiR miR-20b. Although the four microRNAs seem to be important in DLBCL pathogenesis, they were not predictive of DLBCL onset or relapse in the serum independent cohort.Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), BrazilFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), BrazilUniv Fed Sao Paulo, Dept Oncol Clin & Expt, Sao Paulo, BrazilAC Camargo Canc Ctr, Sao Paulo, BrazilInsper Inst Educ & Res, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Patol, Sao Paulo, BrazilUniv Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USAUniv Fed Sao Paulo, Dept Oncol Clin & Expt, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Patol, Sao Paulo, BrazilFAPESP: 2010/17668-6Web of Scienc