Mitochondria and Metabolism in Right Heart Failure

Heart failure (HF) is a clinically complex and heterogenous disease characterized by an inability of the heart to pump sufficient blood to the periphery. As such, it has historically been thought of and studied as a disease of the left ventricle (LV). While LV failure is the most common form of HF, it is the ability of the right heart to function that predicts survival in many clinical settings. Extrapolation of mechanisms of left HF to the right ventricle (RV) has yet to prove fruitful in identification of therapeutic approaches, in large part due to a lack of basic mechanistic understanding of the RV which is embryologically, anatomically, and physiologically distinct from the LV. The failing LV is characterized by mitochondrial dysfunction and a metabolic switch, both of which contribute to an energetically starved heart with poor contractile ability. These mechanisms, however, are far less described in the failing RV. The purpose of this chapter is to present the current literature examining the role of mitochondria and metabolism in the healthy right heart, treatments to target deficits in the failing RV, and to identify knowledge gaps for future research in this clinically important area

Ptychographic X-ray computed tomography of extended colloidal networks in food emulsions

As a main structural level in colloidal food materials, extended colloidal networks are important for texture and rheology. By obtaining the 3D microstructure of the network, macroscopic mechanical properties of the material can be inferred. However, this approach is hampered by the lack of suitable non-destructive 3D imaging techniques with submicron resolution. We present results of quantitative ptychographic X-ray computed tomography applied to a palm kernel oil based oil-in-water emulsion. The measurements were carried out at ambient pressure and temperature. The 3D structure of the extended colloidal network of fat globules was obtained with a resolution of around 300 nm. Through image analysis of the network structure, the fat globule size distribution was computed and compared to previous findings. In further support, the reconstructed electron density values were within 4% of reference values.Comment: 19 pages, 4 figures, to be published in Food Structur

Political hashtag publics and counter-visuality: a case study of #fertilityday in Italy

In 2016 the Italian health ministry launched the ‘Fertility Day’ campaign, aimed at tackling Italy’s low birth rate. Under the accusation of delivering sexist and racist messages, the campaign became a trending topic on Twitter, and a protest was launched to be held during Fertility Day. By applying a combination of digital methods and visual content analysis to the #fertilityday Twitter stream, this paper contributes to existing research on the deliberative strength of political hashtag publics, with a particular focus on their power structures, communication patterns and visual content use. Findings on gatekeeping dynamics downsize optimistic views on the democratising potential of Twitter’s socio-technical infrastructure as they point to the emergence of online satirical media and ‘tweetstars’ – along with mainstream news media– as main producers of spreadable content, with ordinary users only surfacing when traditional media elites and new satirical actors lack or lose interest in the debate. Results confirm that political hashtag publics follow acute event communication patterns, with users highly engaged in retweeting and referencing external material and visual content playing a key role in these gatewatching practices. The transient counter-visuality – or critical stance – of tweets with user-manipulated images, however, also suggests that the deliberative potential of these publics is not easily sustainable over time

High Velocity Cloud Complex H: A Satellite of the Milky Way in a Retrograde Orbit?

Observations with the Green Bank Telescope of 21cm HI emission from the high-velocity cloud Complex H suggest that it is interacting with the Milky Way. A model in which the cloud is a satellite of the Galaxy in an inclined, retrograde circular orbit reproduces both the cloud's average velocity and its velocity gradient with latitude. The model places Complex H at approximately 33 kpc from the Galactic Center on a retrograde orbit inclined about 45 degrees to the Galactic plane. At this location it has an HI mass > 6 10^6 Msun and dimensions of at least 10 by 5 kpc. Some of the diffuse HI associated with the cloud has apparently been decelerated by interaction with Galactic gas. Complex H has similarities to the dwarf irregular galaxy Leo A and to some compact high-velocity clouds, and has an internal structure nearly identical to parts of the Magellanic Stream, with a pressure P/k about 100 cm^{-3} K.Comment: 12 pages includes 4 figures. To be published in Astrophysical Journal Letters, 1 July 200

Stoics against stoics in Cudworth's "A Treatise of Freewill"

In his 'A Treatise of Freewill', Ralph Cudworth argues against Stoic determinism by drawing on what he takes to be other concepts found in Stoicism, notably the claim that some things are ‘up to us’ and that these things are the product of our choice. These concepts are central to the late Stoic Epictetus and it appears at first glance as if Cudworth is opposing late Stoic voluntarism against early Stoic determinism. This paper argues that in fact, despite his claim to be drawing on Stoic doctrine, Cudworth uses these terms with a meaning first articulated only later, by the Peripatetic commentator Alexander of Aphrodisias

Sparsity of integer solutions in the average case

We examine how sparse feasible solutions of integer programs are, on average. Average case here means that we fix the constraint matrix and vary the right-hand side vectors. For a problem in standard form with m equations, there exist LP feasible solutions with at most m many nonzero entries. We show that under relatively mild assumptions, integer programs in standard form have feasible solutions with O(m) many nonzero entries, on average. Our proof uses ideas from the theory of groups, lattices, and Ehrhart polynomials. From our main theorem we obtain the best known upper bounds on the integer Carathéodory number provided that the determinants in the data are small