4 research outputs found
Laboratory Test Campaign Aimed at the Analysis of an Uncommon Wear Phenomenon in a Marble Quarry
The use of ornamental stones has a historical value that makes them strategically precious in Italy; marble can offer high performance in architectural applications, even though the variability of the rock mass requires detailed studies to optimize the exploitation techniques and reduce waste. Italy is world famous for its marble, which is extracted mainly through chainsaw cutting machines, which are currently used intensively due to their high-safety working conditions compared to alternative techniques and for their great versatility, especially in underground applications. Although this cutting technique is well-rooted, an uncommon problem of tool wear was found in the quarry under study, which strongly affected productivity. A series of laboratory test were carried out to estimate the wear potential of the rock and the suitability of the tools. The Cerchar abrasivity test highlighted a mean wear potential for the marble of 2.77, while microhardness outcomes pointed out the presence of quartz veins in the tested material (values over 10,000 MPa). Finally, additives typically used in the conditioning process of EPB machines in tunneling were tested with the purpose of reducing the extent of wear. A reduction of about 50% in the wear (in terms of weight lost) was obtained for a moisture content of 9%
Laboratory Test Campaign Aimed at the Analysis of an Uncommon Wear Phenomenon in a Marble Quarry
The use of ornamental stones has a historical value that makes them strategically precious in Italy; marble can offer high performance in architectural applications, even though the variability of the rock mass requires detailed studies to optimize the exploitation techniques and reduce waste. Italy is world famous for its marble, which is extracted mainly through chainsaw cutting machines, which are currently used intensively due to their high-safety working conditions compared to alternative techniques and for their great versatility, especially in underground applications. Although this cutting technique is well-rooted, an uncommon problem of tool wear was found in the quarry under study, which strongly affected productivity. A series of laboratory test were carried out to estimate the wear potential of the rock and the suitability of the tools. The Cerchar abrasivity test highlighted a mean wear potential for the marble of 2.77, while microhardness outcomes pointed out the presence of quartz veins in the tested material (values over 10,000 MPa). Finally, additives typically used in the conditioning process of EPB machines in tunneling were tested with the purpose of reducing the extent of wear. A reduction of about 50% in the wear (in terms of weight lost) was obtained for a moisture content of 9%
Polymyxin-B hemoperfusion in septic patients: analysis of a multicenter registry
Background: In 2010, the EUPHAS 2 collaborative group created a registry with the purpose of recording data from critically ill patients suffering from severe sepsis and septic shock treated with polymyxin-B hemoperfusion (PMX-HP) for endotoxin removal. The aim of the registry was to verify the application of PMX-HP in the daily clinical practice. Methods: The EUPHAS 2 registry involved 57 centers between January 2010 and December 2014, collecting retrospective data of 357 patients (297 in Europe and 60 in Asia) suffering from severe sepsis and septic shock caused by proved or suspected infection related to Gram negative bacteria. All patients received atleast one cycle of extracorporeal endotoxin removal by PMX-HP. Results: Septic shock was diagnosed in 305 (85.4 %) patients. The most common source of infection was abdominal (44.0 %) followed by pulmonary (17.6 %). Gram negative bacteria represented 60.6 % of the pathogens responsible of infection. After 72 h from the first cycle of PMX-HP, some of the SOFA score components significantly improved with respect to baseline: cardiovascular (2.16 \ub1 1.77 from 3.32 \ub1 1.29, p < 0.0001), respiratory (1.95 \ub1 0.95 from 2.40 \ub1 1.06, p < 0.001) and renal (1.84 \ub1 1.77 from 2.23 \ub1 1.62, p = 0.013). Overall 28-day survival rate was 54.5 % (60.4 % in abdominal and 47.5 % in pulmonary infection). Patients with abdominal infection treated with PMX-HP within 24 h from the diagnosis of septic shock had a 28-day survival rate of 64.5 %. Patients showing a significantly cardiovascular improvement after PMX-HP had a 28-survival rate of 75 % in comparison to the 39 % of patients who did not (p < 0.001). Cox regression analysis found the variation of cardiovascular, respiratory and coagulation SOFA to be independent covariates for 28-day survival. In European patients were observed a higher 28-day (58.8 vs. 34.5 %, p = 0.003), ICU (59 vs. 36.7 %, p = 0.006) and hospital survival rate (53.2 vs. 35 %, p = 0.02) than in Asian patients. However, the two populations were highly heterogeneous in terms of source of infection and severity scores at admission. Conclusion: The EUPHAS 2 is the largest registry conducted outside Japan on the clinical use of PMX-HP in septic patients. Data analysis confirmed the feasibility of PMX-HP to treat septic patients in daily clinical practice, showing clinical benefits associated with endotoxin removal without significant adverse events related to the extracorporeal technique