Development and validation of a framework allowing the evaluation of photovoltaic and photosynthetic productions of agrivoltaic systems

PhD Proposal on the development of a modeling framework for agrivoltaics13. Climate action7. Affordable and clean energy2. Zero hunge

Differential DAergic Control of D1 and D2 Receptor Agonist Over Locomotor Activity and GABA Level in the Striatum

The basal ganglia, a group of nuclei, are associated with a variety of functions, including motor control. The striatum, which is the major input station of the basal ganglia in the brain, is regulated in part by dopaminergic input from the substantia nigra. The striatum is made up 96% of medium spiny neurons which are GABAergic cells. GABAergic cells are known to contain DA receptors which divide into two main branches- the D1 receptor (D1R)-expressing direct pathway and the D2 receptor (D2R)-expressing indirect pathway. The role of these two efferent pathways has not been clear in control of motor behaviors. To establish the influence of the different DA subtypes on GABAergic systems in the striatum, D1 selective receptor agonist (SKF 38393) and D2 selective receptor agonist (Quinpirole) were administered to mice. SKF 38393 and quinpirole were administered intraperitoneally in a volume of 0, 1, 5, 10 (mg/kg) and motor activity was assessed for 60 min immediately after the injection of DA agonists. Mice were sacrificed after behavioral test and the striatum in the brain were dissected for analysis of GABA level with HPLC. Both SKF 38393 and quinpirole dose-dependently increased locomotor activity but, GABA level in the striatum was clearly different in two agonists. These findings provide insight into the selective contributions of the direct and indirect pathways to striatal GABAergic motor behaviors

Effects of JL13, a Pyridobenzoxazepine with Potential Atypical Antipsychotic Activity, in Animal Models for Schizophrenia

ABSTRACT JL13 [5-(4-methylpiperazin-1-yl)-8-chloro-pyrido [2,3-b][1,5] benzoxazepine fumarate] is a substance with a close structural resemblance to clozapine. However, it is less sensitive to oxidation and may therefore have less hematological side effects. In the present study, JL13 was compared with clozapine and haloperidol in several animal models for schizophrenia. The paw test represents a screening model for antipsychotic drugs that can discriminate between drugs with extrapyramidal side effects and drugs without. Haloperidol increased both forelimb retraction time and hindlimb retraction time (HRT), whereas both clozapine and JL13 increased only HRT. In the prepulse inhibition paradigm, all three drugs reversed the apomorphineand the amphetamine-induced disruption of prepulse inhibition. However, whereas haloperidol was equally effective against both dopaminergic drugs, JL13 and clozapine were more effective against amphetamine. Finally, only JL13 was able to increase prepulse inhibition in normal rats, whereas only clozapine reduced basal startle amplitude. Taken together, these data suggest that JL13 may be an effective antipsychotic drug, with a profile similar to clozapine

PASE : Python Agrivoltaic Simulation Environment

PASE is an open-source simulation framework for agrivoltaics that allows to estimate both energy and spatialized crop production in specified agrivoltaic configurations, location soil and climate.7. Affordable and clean energy13. Climate action2. Zero hungerPython environment to model crop and photovoltaic productivity of agrivoltaic systems. Released versions are also available on gitlab: https://gitlab.uliege.be/pase1.

The use of radioreceptor assays for the determination of benzodiazepines in biological samples: a review.

Benzodiazepines are the most widely prescribed class of psychotropes. The demonstration of specific, high affinity binding sites for benzodiazepines in mammalian brain has provided a basis for a radioreceptor assay (RRA) of these compounds in biological samples (fluids or tissues). The RRA permits the simultaneous measurement of the benzodiazepine molecules that bind to the receptor, providing a total estimate of all pharmacologically active forms of the drug, which is useful in drug monitoring and in the intensive care of patients. After a complete description of the methodological aspects of this technique, the results obtained in therapeutic monitoring and in toxicological analysis are reviewed, and the advantages and disadvantages of this method are examined