10,058 research outputs found
The Orion constellation as an installation - An innovative three dimensional teaching and learning environment
Visualising the three dimensional distribution of stars within a
constellation is highly challenging for both students and educators, but when
carried out in an interactive collaborative way it can create an ideal
environment to explore common misconceptions about size and scale within
astronomy. We present how the common table top activities based upon the Orion
constellation miss out on this opportunity. Transformed into a walk-through
Orion installation that includes the position of our Solar system, it allows
the students to fully immerse themselves within the model and experience
parallax. It enables participants to explore within the installation many other
aspects of astronomy relating to sky culture, stellar evolution, and stellar
timescales establishing an innovative learning and teaching environment.Comment: 2 pages, submitted to The Physics Teacher - Colum
A Review of the Open Educational Resources (OER) Movement: Achievements, Challenges, and New Opportunities
Examines the state of the foundation's efforts to improve educational opportunities worldwide through universal access to and use of high-quality academic content
Duration judgements in patients with schizophrenia
Background. The ability to encode time cues underlies many cognitive processes. In the light of schizophrenic patients' compromised cognitive abilities in a variety of domains, it is noteworthy that there are numerous reports of these patients displaying impaired timing abilities. However, the timing intervals that patients have been evaluated on in prior studies vary considerably in magnitude (e.g. 1 s, 1 min, 1 h etc.).
Method. In order to obviate differences in abilities in chronometric counting and place minimal demands on cognitive processing, we chose tasks that involve making judgements about brief durations of time (<1 s).
Results. On a temporal generalization task, patients were less accurate than controls at recognizing a standard duration. The performance of patients was also significantly different from controls on a temporal bisection task, in which participants categorized durations as short or long. Although time estimation may be closely intertwined with working memory, patients' working memory as measured by the digit span task did not correlate significantly with their performance on the duration judgement tasks. Moreover, lowered intelligence scores could not completely account for the findings.
Conclusions. We take these results to suggest that patients with schizophrenia are less accurate at estimating brief time periods. These deficits may reflect dysfunction of biopsychological timing processes
Nonperturbative contributions to the QCD pressure
We summarize the most important arguments why a perturbative description of
finite-temperature QCD is unlikely to be possible and review various
well-established approaches to deal with this problem. Then, using a recently
proposed method, we investigate nonperturbative contributions to the QCD
pressure and other observables (like energy, anomaly and bulk viscosity)
obtained by imposing a functional cutoff at the Gribov horizon. Finally, we
discuss how such contributions fit into the picture of consecutive effective
theories, as proposed by Braaten and Nieto, and give an outline of the next
steps necessary to improve this type of calculation.Comment: 15 pages, 13 figures, uses xcolor.sty; in v2 quality of some figures
has been improved, discussion of other approaches has been extende
Arabidopsis accelerated cell death 11, ACD11, is a ceramide-1-phosphate transfer protein and intermediary regulator of phytoceramide levels
The accelerated cell death 11 (acd11) mutant of Arabidopsis provides a genetic model for studying immune response activation and localized cellular suicide that halt pathogen spread during infection in plants. Here, we elucidate ACD11 structure and function and show that acd11 disruption dramatically alters the in vivo balance of sphingolipid mediators that regulate eukaryotic-programmed cell death. In acd11 mutants, normally low ceramide-1- phosphate (C1P) levels become elevated, but the relatively abundant cell death inducer phytoceramide rises acutely. ACD11 exhibits selective intermembrane transfer of C1P and phyto-C1P. Crystal structures establish C1P binding via a surface-localized, phosphate headgroup recognition center connected to an interior hydrophobic pocket that adaptively ensheaths lipid chains via a cleft-like gating mechanism. Point mutation mapping con- firms functional involvement of binding site residues. A p helix (p bulge) near the lipid binding cleft distinguishes apo-ACD11 from other GLTP folds. The global two-layer, a-helically dominated, āāsandwichāā topology displaying C1P-selective binding identifies ACD11 as the plant prototype of a GLTP fold subfamily
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Exposure-Lag-Response in Longitudinal Studies: Application of Distributed-Lag Nonlinear Models in an Occupational Cohort.
Prolonged exposures can have complex relationships with health outcomes, as timing, duration, and intensity of exposure are all potentially relevant. Summary measures such as cumulative exposure or average intensity of exposure may not fully capture these relationships. We applied penalized and unpenalized distributed-lag nonlinear models (DLNMs) with flexible exposure-response and lag-response functions in order to examine the association between crystalline silica exposure and mortality from lung cancer and nonmalignant respiratory disease in a cohort study of 2,342 California diatomaceous earth workers followed during 1942-2011. We also assessed associations using simple measures of cumulative exposure assuming linear exposure-response and constant lag-response. Measures of association from DLNMs were generally higher than those from simpler models. Rate ratios from penalized DLNMs corresponding to average daily exposures of 0.4 mg/m3 during lag years 31-50 prior to the age of observed cases were 1.47 (95% confidence interval (CI): 0.92, 2.35) for lung cancer mortality and 1.80 (95% CI: 1.14, 2.85) for nonmalignant respiratory disease mortality. Rate ratios from the simpler models for the same exposure scenario were 1.15 (95% CI: 0.89, 1.48) and 1.23 (95% CI: 1.03, 1.46), respectively. Longitudinal cohort studies of prolonged exposures and chronic health outcomes should explore methods allowing for flexibility and nonlinearities in the exposure-lag-response
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