643 research outputs found
Magnetic Reversal in Nanoscopic Ferromagnetic Rings
We present a theory of magnetization reversal due to thermal fluctuations in
thin submicron-scale rings composed of soft magnetic materials. The
magnetization in such geometries is more stable against reversal than that in
thin needles and other geometries, where sharp ends or edges can initiate
nucleation of a reversed state. The 2D ring geometry also allows us to evaluate
the effects of nonlocal magnetostatic forces. We find a `phase transition',
which should be experimentally observable, between an Arrhenius and a
non-Arrhenius activation regime as magnetic field is varied in a ring of fixed
size.Comment: RevTeX, 23 pages, 7 figures, to appear in Phys. Rev.
Fermions and Kaluza-Klein vacuum decay: a toy model
We address the question of whether or not fermions with twisted periodicity
condition suppress the semiclassical decay of M^4xS^1 Kaluza--Klein vacuum. We
consider a toy (1+1)-dimensional model with twisted fermions in cigar-shaped
Euclidean background geometry and calculate the fermion determinant. We find
that contrary to expectations, the determinant is finite. We consider this as
an indication that twisted fermions do not stabilize the Kaluza--Klein vacuum.Comment: 13 pages, 2 figure
Myosin II regulates the shape of three-dimensional intestinal epithelial cysts.
The development of luminal organs begins with the formation of spherical cysts composed of a single layer of epithelial cells. Using a model three-dimensional cell culture, this study examines the role of a cytoskeletal motor, myosin II, in cyst formation. Caco-2 and SK-CO15 intestinal epithelial cells were embedded into Matrigel, and myosin II was inhibited by blebbistatin or siRNA-mediated knockdown. Whereas control cells formed spherical cysts with a smooth surface, inhibition of myosin II induced the outgrowth of F-actin-rich surface protrusions. The development of these protrusions was abrogated after inhibition of F-actin polymerization or of phospholipase C (PLC) activity, as well as after overexpression of a dominant-negative ADF/cofilin. Surface protrusions were enriched in microtubules and their formation was prevented by microtubule depolymerization. Myosin II inhibition caused a loss of peripheral F-actin bundles and a submembranous extension of cortical microtubules. Our findings suggest that inhibition of myosin II eliminates the cortical F-actin barrier, allowing microtubules to reach and activate PLC at the plasma membrane. PLC-dependent stimulation of ADF/cofilin creates actin-filament barbed ends and promotes the outgrowth of F-actin-rich protrusions. We conclude that myosin II regulates the spherical shape of epithelial cysts by controlling actin polymerization at the cyst surface
Casimir energy in the MIT bag model
The vacuum energies corresponding to massive Dirac fields with the boundary
conditions of the MIT bag model are obtained. The calculations are done with
the fields occupying the regions inside and outside the bag, separately. The
renormalization procedure for each of the situations is studied in detail, in
particular the differences occurring with respect to the case when the field
extends over the whole space. The final result contains several constants
undergoing renormalization, which can be determined only experimentally. The
non-trivial finite parts which appear in the massive case are found exactly,
providing a precise determination of the complete, renormalized zero-point
energy for the first time, in the fermionic case. The vacuum energy behaves
like inverse powers of the mass for large masses.Comment: 19 pages, Latex, 1 Postscript figure, submitted to J. Phys.
The relationship between glutamate, dopamine, and cortical gray matter: A simultaneous PET-MR study
Prefrontal cortex has been shown to regulate striatal dopaminergic function via glutamatergic mechanisms in preclinical studies. Concurrent disruption of these systems is also often seen in neuropsychiatric disease. The simultaneous measurement of striatal dopamine signaling, cortical gray matter, and glutamate levels is therefore of major interest, but has not been previously reported. In the current study, twenty-eight healthy subjects underwent 2 simultaneous [11C]-( + )-PHNO PET-MRI scans, once after placebo and once after amphetamine in a double-blind randomized cross-over design, to measure striatal dopamine release, striatal dopamine receptor (D2/3R) availability, anterior cingulate glutamate+glutamine (Glx) levels, and cortical gray matter volumes at the same time. Voxel-based morphometry was used to investigate associations between neurochemical measures and gray matter volumes. Whole striatum D2/3R availability was positively associated with prefrontal cortex gray matter volume (pFWE corrected = 0.048). This relationship was mainly driven by associative receptor availability (pFWE corrected = 0.023). In addition, an interaction effect was observed between sensorimotor striatum D2/3R availability and anterior cingulate Glx, such that in individuals with greater anterior cingulate Glx concentrations, D2/3R availability was negatively associated with right frontal cortex gray matter volumes, while a positive D2/3R-gray matter association was observed in individuals with lower anterior cingulate Glx levels (pFWE corrected = 0.047). These results are consistent with the hypothesis that the prefrontal cortex is involved in regulation of striatal dopamine function. Furthermore, the observed associations raise the possibility that this regulation may be modulated by anterior cingulate glutamate concentrations
Characterizing a rare neurogenetic disease, SLC13A5 citrate transporter disorder, utilizing clinical data in a cloud-based medical record collection system
Introduction: SLC13A5 citrate transporter disorder is a rare autosomal recessive genetic disease that has a constellation of neurologic symptoms. To better characterize the neurologic and clinical laboratory phenotype, we utilized patient medical records collected by Ciitizen, an Invitae company, with support from the TESS Research Foundation.Methods: Medical records for 15 patients with a suspected genetic and clinical diagnosis of SLC13A5 citrate transporter disorder were collected by Ciitizen, an Invitae company. Genotype, clinical phenotypes, and laboratory data were extracted and analyzed.Results: The 15 patients reported all had epilepsy and global developmental delay. Patients continued to attain motor milestones, though much later than their typically developing peers. Clinical diagnoses support abnormalities in communication, and low or mixed tone with several movement disorders, including, ataxia and dystonia. Serum citrate was elevated in the 3 patients in whom it was measured; other routine laboratory studies assessing renal, liver and blood function had normal values or no consistent abnormalities. Many electroencephalograms (EEGs) were performed (1 to 35 per patient), and most but not all were abnormal, with slowing and/or epileptiform activity. Fourteen of the patients had one or more brain magnetic resonance imaging (MRI) reports: 7 patients had at least one normal brain MRI, but not with any consistent findings except white matter signal changes.Discussion: These results show that in addition to the epilepsy phenotype, SLC13A5 citrate transporter disorder impacts global development, with marked abnormalities in motor abilities, tone, coordination, and communication skills. Further, utilizing cloud-based medical records allows industry, academic, and patient advocacy group collaboration to provide preliminary characterization of a rare genetic disorder. Additional characterization of the neurologic phenotype will be critical to future study and developing treatment for this and related rare genetic disorders
The SPLASH Survey: Kinematics of Andromeda's Inner Spheroid
The combination of large size, high stellar density, high metallicity, and
Sersic surface brightness profile of the spheroidal component of the Andromeda
galaxy (M31) within R_proj ~ 20 kpc suggest that it is unlike any subcomponent
of the Milky Way. In this work we capitalize on our proximity to and external
view of M31 to probe the kinematical properties of this "inner spheroid." We
employ a Markov chain Monte Carlo (MCMC) analysis of resolved stellar
kinematics from Keck/DEIMOS spectra of 5651 red giant branch stars to
disentangle M31's inner spheroid from its stellar disk. We measure the mean
velocity and dispersion of the spheroid in each of five spatial bins after
accounting for a locally cold stellar disk as well as the Giant Southern Stream
and associated tidal debris. For the first time, we detect significant spheroid
rotation (v_rot ~ 50 km/s) beyond R_proj ~ 5 kpc. The velocity dispersion
decreases from about 140 km/s at R_proj = 7 kpc to 120 km/s at R_proj = 14 kpc,
consistent to 2 sigma with existing measurements and models. We calculate the
probability that a given star is a member of the spheroid and find that the
spheroid has a significant presence throughout the spatial extent of our
sample. Lastly, we show that the flattening of the spheroid is due to velocity
anisotropy in addition to rotation. Though this suggests that the inner
spheroid of M31 more closely resembles an elliptical galaxy than a typical
spiral galaxy bulge, it should be cautioned that our measurements are much
farther out (2 - 14 r_eff) than for the comparison samples.Comment: Accepted for publication in Ap
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