US Cosmic Visions: New Ideas in Dark Matter 2017: Community Report

This white paper summarizes the workshop "U.S. Cosmic Visions: New Ideas in Dark Matter" held at University of Maryland on March 23-25, 2017

Influence of circadian phase and extended wakefulness on glucose levels during forced desynchrony

Objectives Circadian misalignment and sleep deprivation often occur in tandem, and both negatively impact glucose homeostasis and metabolic health. The present study employed a forced desynchrony protocol to examine the influence of extended wakefulness and circadian misalignment on hourly glucose levels. Methods Nine healthy adults (4F/5M; 26 ± 4 years) completed a 31-day in-laboratory protocol. After three 24 hour baseline days with 8 hours scheduled sleep opportunities, participants were scheduled to 14 consecutive 42.85 hour sleep-wake cycles, with 28.57 hours extended wakefulness and 14.28 hours sleep opportunities each cycle. Blood was sampled hourly across the forced desynchrony and over 600 plasma samples per participant were analyzed for glucose levels. Results Both hours into the 42.85 hours forced desynchrony day and circadian phase modulated glucose levels (p < .0001). Glucose peaked after each meal during scheduled wakefulness and decreased during scheduled sleep/fasting. Glucose levels were, on average, lowest during the biological daytime and rose throughout the biological night, peaking in the biological morning. When analyzed separately for scheduled sleep vs. wakefulness, the peak timing of the circadian rhythm in glucose was later during sleep (p < .05). Glucose area under the curve levels increased rapidly from the beginning of the forced desynchrony protocol and were highest on the second forced desynchrony day (p < .01), returning towards forced desynchrony day 1 levels thereafter. Conclusions These findings have important implications for understanding factors contributing to altered glucose metabolism during sleep loss and circadian misalignment, and for potential physiological adaptation of metabolism in healthy adults, who are increasingly exposed to such conditions in our society

Theories and Experiments for Testable Baryogenesis Mechanisms: A Snowmass White Paper

The baryon asymmetry of the Universe is one of the central motivations to expect physics beyond the Standard Model. In this Snowmass white paper, we review the challenges and opportunities in testing some of the central paradigms that predict physics at scales low enough to expect new experimental data in the next decade. Focusing on theoretical ideas and some of their experimental implications, in particular, we discuss neutron-antineutron transformations, flavor observables, next generation colliders, future neutron facilities, gravitational waves, searches for permanent electric dipole moments, $0\nu \beta \beta$ decay and some future large underground experiments as methods to test post-sphaleron baryogenesis, electroweak baryogenesis, mesogenesis and low scale leptogenesis. Finally, we comment on the cases where high scale physics can be probed through some of these same mechanisms

Theories and Experiments for Testable Baryogenesis Mechanisms: A Snowmass White Paper

The baryon asymmetry of the Universe is one of the central motivations to expect physics beyond the Standard Model. In this Snowmass white paper, we review the challenges and opportunities in testing some of the central paradigms that predict physics at scales low enough to expect new experimental data in the next decade. Focusing on theoretical ideas and some of their experimental implications, in particular, we discuss neutron-antineutron transformations, flavor observables, next generation colliders, future neutron facilities, gravitational waves, searches for permanent electric dipole moments, $0\nu \beta \beta$ decay and some future large underground experiments as methods to test post-sphaleron baryogenesis, electroweak baryogenesis, mesogenesis and low scale leptogenesis. Finally, we comment on the cases where high scale physics can be probed through some of these same mechanisms

New search for mirror neutron regeneration

The possibility of relatively fast neutron oscillations into a mirror neutron state is not excluded experimentally when a mirror magnetic field is considered. Direct searches for the disappearance of neutrons into mirror neutrons in a controlled magnetic field have previously been performed using ultracold neutrons, with some anomalous results reported. We describe a technique using cold neutrons to perform a disappearance and regeneration search, which would allow us to unambiguously identify a possible oscillation signal. An experiment using the existing General Purpose-Small Angle Neutron Scattering instrument at the High Flux Isotope Reactor at Oak Ridge National Laboratory will have the sensitivity to fully explore the parameter space of prior ultracold neutron searches and confirm or refute previous claims of observation. This instrument can also conclusively test the validity of recently suggested oscillation-based explanations for the neutron lifetime anomaly

Attachment, Aggression, and Family Risk in a Low-Income Sample

Attachment security in children\u27s first relationships with their primary caregivers in infancy supports multiple aspects of their social development during childhood. Insecure attachment, in contrast, underlies a wide range of negative outcomes for children, including aggressive behavior toward others. In a sample of 161 low-income families, early attachment insecurity was examined in relation to physical punishment and child aggression at ages two and three in the context of risk and intervention. Families had been randomly assigned either to a comparison group or to an Early Head Start program that provided weekly home visits aimed at increasing positive aspects of parenting behaviors. Children with higher security scores were less likely to be spanked at age three and less likely to be aggressive at ages two and three. Early Head Start made an independent contribution to less spanking at age three, over and above family risk factors, earlier attachment security, or earlier spanking. The results suggest that a secure attachment relationship and a parenting-focused home visiting intervention can reduce the physical punishment associated with child aggression and thereby indirectly reduce early childhood aggression