The response of burrow-nesting petrels and other vulnerable bird species to vertebrate pest management and climate change on sub-Antarctic Macquarie Island

Pest species management is causing rapid and significant changes to burrow-nesting petrel populations on sub-Antarctic Macquarie Island. The Weka, Gallirallus australis, was eliminated by 1989 and the Feral Cat, Felis catus, eradicated in 2000. The most abundant burrownesting petrel species currently, White-headed Petrels, Pterodroma lessonii, Antarctic Prions, Pachyptila desolata, and Sooty Shearwaters, Puffinus griseus, have yet to increase in numbers, but are expected to do so in the absence of cats. This study found evidence that Grey Petrels, Procell aria cinerea, began breeding again on the island in 1999, after an absence of over 100 years. Blue Petrels, Halobaena caerulea, and Fairy Prions, Pachyptila turtur, were found to be re-colonising Macquarie Island from offshore stacks after a similar absence. South Georgian Diving-Petrels, Pelecanoides georgicus, were also possibly recolonising the island. Despite the presence of Black Rats, Rattus rattus, most of the bird species discussed are considered capable of population increase. If European Rabbits, Oryctolagus cuniculus, are not eliminated or maintained in reduced numbers, some petrel populations will never fully recover. Climate change could have a negative impact on burrow-nesting petrels, and is likely to exacerbate the detrimental effects of the remaining pest species on vulnerable indigenous bird species, compounding the need for remedial action against rabbits in particular. Together with predictions that other petrel species will now return to breed, certain terrestrial bird species, alien to the region, may invade Macquarie Island as a consequence of the combination of pest eradication and changing climatic conditions

St.Louis Blues / music by W. C. Handy; words by W. C. Handy

Cover: photo inset of Marion Harris; Publisher: Handy Brothers Music Co. (New York)https://egrove.olemiss.edu/sharris_c/1069/thumbnail.jp

Saint Louis Blues / music by W. C. Handy; words by W. C. Handy

Cover: photo of Rudy Vallee; Publisher: Handy Brothers Music Co. (New York)https://egrove.olemiss.edu/sharris_c/1070/thumbnail.jp

Comparing Species of Bees for Controlled Pollination of Helianthus petiolaris in Field Cages

Honey bees, Apis mellifera, have been used for several years to pollinate caged plant species maintained at the USDA-ARS North Central Regional Plant Introduction Station (NCRPIS), Ames, Iowa. Because maintaining large numbers of honey bees is expensive and time consuming, we began looking in 1995 for other pollinator species that can be easily managed and less expensive to maintain than A. mellifera. One species we tested was the hornfaced bee, Osmia cornifrons, a solitary bee imported from Japan in the late 1970s. We also tested a mixture of native bumblebees, Bombus bimaculatus and B. impatiens, which are native to the U.S. Midwest. These bee species were compared in field cages to determine which would produce the greatest number of seeds/plant on the wild annual sunflower, Helianthus petiolaris. After 2 years testing, honey bees consistently produced more seeds/plant than did the other bees tested

Saint Louis Blues / music by W.C. Handy; words by W.C. Handy

Cover: photo of clarinetist Ted Lewis; Publisher: Handy Brothers Music Co. (New York)https://egrove.olemiss.edu/sharris_e/1063/thumbnail.jp

Saint Louis Blues / music by W.C. Handy; words by W.C. Handy

Cover: photo of Nat King Cole and his band; Publisher: Handy Brothers Music Co. (New York)https://egrove.olemiss.edu/sharris_e/1064/thumbnail.jp

St.Louis Blues / music by W.C. Handy; words by W.C. Handy

Cover: photo inset of W. C. Handy playing trumpet; Publisher: Handy Brothers Music Co. (New York)https://egrove.olemiss.edu/sharris_e/1062/thumbnail.jp

Acute Flavanol Supplementation Improves the Attenuated Cerebral Vasodilatory Capacity in Young African Americans

African Americans (AA) have increased risk for cerebral vascular disease including stroke, Alzheimer’s disease, or dementia relative to Caucasian Americans (CA). Our recent study found that AA have attenuated cerebral vasodilatory response to rebreathing-induced hypercapnia when compared with CA. Thus, we hypothesized that acute flavanol intake restores blunted cerebral responses in AA. Fourteen healthy college-aged AA and 14 age- and sex-matched CA participants were studied. A four-parameter logistic regression was used for curve fitting the responses of cerebral vascular conductance (%CVCi) relative to changes in end-tidal carbon dioxide concentration. In AA, there were significant improvements in total range of changes in %CVCi (a) and the maximum increase in %CVCi (y0) with flavanol beverage (a; pre: 46.4 ± 16 vs. post: 64.4 ± 19 %CVCi; P = 0.007, y0; pre: 151.1 ± 18 vs. post: 166.0 ± 22 %CVCi; P = 0.002); however, there were no differences in a and y0 with placebo (a; pre: 52.5 ± 19 vs. post: 51.7 ± 17 %CVCi; P = 0.35, y0; pre: 156.2 ± 20 vs. post: 151.3 ± 17 %CVCi; P = 0.26). In CA, no differences in a and y0 with flavanol (a; pre: 73.7 ± 18 vs. post: 71.7 ± 22 %CVCi; P = 0.70, y0; pre: 175.7 ± 20 %CVCi vs. post: 175.6 ± 22 %CVCi; P = 0.99) or placebo (a; pre: 75.7 ± 15 vs. post: 80.1 ± 20 %CVCi; P = 0.24, y0; pre: 177.4 ± 21 %CVCi vs. post: 180.6 ± 25 %CVCi; P = 0.45) were observed. In conclusion, acute flavanol supplementation increases the total range of changes in cerebral vascular conductance as well as maximum vascular conductance in AA, effectively abolishing the ethnic-related difference in cerebral vasodilatory capacity in response to rebreathing-induced hypercapnia

MEPicides: Potent antimalarial prodrugs targeting isoprenoid biosynthesis

AbstractThe emergence of Plasmodium falciparum resistant to frontline therapeutics has prompted efforts to identify and validate agents with novel mechanisms of action. MEPicides represent a new class of antimalarials that inhibit enzymes of the methylerythritol phosphate (MEP) pathway of isoprenoid biosynthesis, including the clinically validated target, deoxyxylulose phosphate reductoisomerase (Dxr). Here we describe RCB-185, a lipophilic prodrug with nanomolar activity against asexual parasites. Growth of P. falciparum treated with RCB-185 was rescued by isoprenoid precursor supplementation, and treatment substantially reduced metabolite levels downstream of the Dxr enzyme. In addition, parasites that produced higher levels of the Dxr substrate were resistant to RCB-185. Notably, environmental isolates resistant to current therapies remained sensitive to RCB-185, the compound effectively treated sexually-committed parasites, and was both safe and efficacious in malaria-infected mice. Collectively, our data demonstrate that RCB-185 potently and selectively inhibits Dxr in P. falciparum, and represents a promising lead compound for further drug development.</jats:p