Summary of along-track data from the earth radiation budget satellite for several representative ocean regions

For several days in January and August 1985, the Earth Radiation Budget Satellite, a component of the Earth Radiation Budget Experiment (ERBE), was operated in an along-track scanning mode. A survey of radiance measurements taken in this mode is given for five ocean regions: the north and south Atlantic, the Arabian Sea, the western Pacific north of the Equator, and part of the Intertropical Convergence Zone. Each overflight contains information about the clear scene and three cloud categories: partly cloudy, mostly cloudy, and overcast. The data presented include the variation of longwave and shortwave radiance in each scene classification as a function of viewing zenity angle during each overflight of one of the five target regions. Several features of interest in the development of anisotropic models are evident, including the azimuthal dependence of shortwave radiance that is an essential feature of shortwave bidirectional models. The data also demonstrate that the scene classification algorithm employed by the ERBE results in scene classifications that are a function of viewing geometry

Summary of along-track data from the Earth radiation budget satellite for several major desert regions

For several days in January and August 1985, the Earth Radiation Budget Satellite, a component of the Earth Radiation Budget Experiment (ERBE), was operated in an along-track scanning mode. A survey of radiance measurements is given for four desert areas in Africa, the Arabian Peninsula, Australia, and the Sahel region of Africa. Each overflight provides radiance information for four scene categories: clear, partly cloudy, mostly cloudy, and overcast. The data presented include the variation of radiance in each scene classification as a function of viewing zenith angle during each overflight of the five target areas. Several features of interest in the development of anisotropic models are evident, including day-night differences in longwave limb darkening and the azimuthal dependence of short wave radiance. There is some evidence that surface features may introduce thermal or visible shadowing that is not incorporated in the usual descriptions of the anisotropic behavior of radiance as viewed from space. The data also demonstrate that the ERBE scene classification algorithms give results that, at least for desert surfaces, are a function of viewing geometry

Lactate: brain fuel in human traumatic brain injury: a comparison with normal healthy control subjects.

We evaluated the hypothesis that lactate shuttling helps support the nutritive needs of injured brains. To that end, we utilized dual isotope tracer [6,6-(2)H2]glucose, that is, D2-glucose, and [3-(13)C]lactate techniques involving arm vein tracer infusion along with simultaneous cerebral (arterial [art] and jugular bulb [JB]) blood sampling. Traumatic brain injury (TBI) patients with nonpenetrating brain injuries (n=12) were entered into the study following consent of patients' legal representatives. Written and informed consent was obtained from control volunteers (n=6). Patients were studied 5.7±2.2 (mean±SD) days post-injury; during periods when arterial glucose concentration tended to be higher in TBI patients. As in previous investigations, the cerebral metabolic rate for glucose (CMRgluc, i.e., net glucose uptake) was significantly suppressed following TBI (p<0.001). However, lactate fractional extraction, an index of cerebral lactate uptake related to systemic lactate supply, approximated 11% in both healthy control subjects and TBI patients. Further, neither the CMR for lactate (CMRlac, i.e., net lactate release), nor the tracer-measured cerebral lactate uptake differed between healthy controls and TBI patients. The percentages of lactate tracer taken up and released as (13)CO2 into the JB accounted for 92% and 91% for control and TBI conditions, respectively, suggesting that most cerebral lactate uptake was oxidized following TBI. Comparisons of isotopic enrichments of lactate oxidation from infused [3-(13)C]lactate tracer and (13)C-glucose produced during hepatic and renal gluconeogenesis (GNG) showed that 75-80% of (13)CO2 released into the JB was from lactate and that the remainder was from the oxidation of glucose secondarily labeled from lactate. Hence, either directly as lactate uptake, or indirectly via GNG, peripheral lactate production accounted for ∼70% of carbohydrate (direct lactate uptake+uptake of glucose from lactate) consumed by the injured brain. Undiminished cerebral lactate fractional extraction and uptake suggest that arterial lactate supplementation may be used to compensate for decreased CMRgluc following TBI

Variability of the coastal current and nutrient pathways in the eastern Gulf of Maine

The eastern Maine coastal current flows southwestward, carrying cold and nutrient-rich waters along the coast from the tidally stirred eastern gulf toward the central and western gulf, where in summer the waters are warmer and more stratified. The current typically turns offshore before reaching Penobscot Bay, near the central coast, at a location determined largely by the distribution of dense slope water in Jordan Basin. The slope water, which enters the gulf as a deep inflow from the Atlantic Ocean, thus plays a major role in determining the intensity, direction and timing of the delivery of nutrients to the interior gulf. In this paper, we use data from two cruises in August 1987 to examine the variability and nutrient transport of the coastal current, especially to show the important physical linkages between the deep slope water, the structure of the coastal current, and its likely significant effect on biological productivity in the gulf

Endogenous Nutritive Support after Traumatic Brain Injury: Peripheral Lactate Production for Glucose Supply via Gluconeogenesis.

We evaluated the hypothesis that nutritive needs of injured brains are supported by large and coordinated increases in lactate shuttling throughout the body. To that end, we used dual isotope tracer ([6,6-(2)H2]glucose, i.e., D2-glucose, and [3-(13)C]lactate) techniques involving central venous tracer infusion along with cerebral (arterial [art] and jugular bulb [JB]) blood sampling. Patients with traumatic brain injury (TBI) who had nonpenetrating head injuries (n=12, all male) were entered into the study after consent of patients' legal representatives. Written and informed consent was obtained from healthy controls (n=6, including one female). As in previous investigations, the cerebral metabolic rate (CMR) for glucose was suppressed after TBI. Near normal arterial glucose and lactate levels in patients studied 5.7±2.2 days (range of days 2-10) post-injury, however, belied a 71% increase in systemic lactate production, compared with control, that was largely cleared by greater (hepatic+renal) glucose production. After TBI, gluconeogenesis from lactate clearance accounted for 67.1% of glucose rate of appearance (Ra), which was compared with 15.2% in healthy controls. We conclude that elevations in blood glucose concentration after TBI result from a massive mobilization of lactate from corporeal glycogen reserves. This previously unrecognized mobilization of lactate subserves hepatic and renal gluconeogenesis. As such, a lactate shuttle mechanism indirectly makes substrate available for the body and its essential organs, including the brain, after trauma. In addition, when elevations in arterial lactate concentration occur after TBI, lactate shuttling may provide substrate directly to vital organs of the body, including the injured brain

Assessing the progression of mild cognitive impairment to Alzheimer's disease: current trends and future directions

With the advent of advances in biomarker detection and neuropsychological measurement, prospects have improved for identifying and tracking the progression of Alzheimer's disease (AD) from its earliest stages through dementia. While new diagnostic techniques have exciting implications for initiating treatment earlier in the disease process, much work remains to be done to optimize the contributions of the expanding range of tools at the disposal of researchers and clinicians. The present paper examines recent work in cerebrospinal fluid biomarkers, magnetic resonance imaging, positron emission tomography, neuropsychological measures, and functional assessment. The strengths and weaknesses of current methodologies are explored and discussed. It is concluded that AD from its mild cognitive impairment state through dementia represents a continuous process, and that progression over time can best be accomplished by interval-level variables. Biomarkers that are most sensitive to early AD may not be the most optimal for monitoring longitudinal change, and it is likely that multivariate models incorporating cognitive measures, functional variables and biomarker data will be the most fruitful avenues for future research

DESI Commissioning Instrument Metrology

The Dark Energy Spectroscopic Instrument (DESI) is under construction to measure the expansion history of the Universe using the Baryon Acoustic Oscillation technique. The spectra of 35 million galaxies and quasars over 14000 sq deg will be measured during the life of the experiment. A new prime focus corrector for the KPNO Mayall telescope will deliver light to 5000 fiber optic positioners. The fibers in turn feed ten broad-band spectrographs. We will describe the methods and results for the commissioning instrument metrology program. The primary goals of this program are to calculate the transformations and further develop the systems that will place fibers within 5um RMS of the target positions. We will use the commissioning instrument metrology program to measure the absolute three axis Cartesian coordinates of the five CCDs and 22 illuminated fiducials on the commissioning instrument