Syntax of Dutch: Adpositions and Adpositional Phrases

The volume Adpositions and Adpositional Phrases discusses the internal make-up and the distribution of adpositional phrases. Topics that are covered include complementation and modification of adpositional phrases, as well as their predicative, attributive and adverbial uses. A separate chapter is devoted to the formation and the syntactic behavior of pronominal PPs like erop ‘on it’, which also includes a more general discussion of the syntax of so-called R-words like er ‘there’

Syntax of Dutch: Adjectives and Adjective Phrases

The Syntax of Dutch will be published in at least seven volumes in the period 2012-2016 and aims at presenting a synthesis of the currently available syntactic knowledge of Dutch. It is primarily concerned with language description and not with linguistic theory, and provides support to all researchers interested in matters relating to the syntax of Dutch, including advanced students of language and linguistics. The volume Adjectives and Adjective Phrases discusses the internal make-up as well as the distribution of adjective phrases. Topics that will be covered include: complementation and modification of adjective phrases; comparative and superlative formation; the attributive, predicative and adverbial uses of adjective phrases. Special attention is paid to the so-called partitive genitive construction and the adverbial use of past/passive participles and infinitives

Syntax of Dutch: Adpositions and Adpositional Phrases

The volume Adpositions and Adpositional Phrases discusses the internal make-up and the distribution of adpositional phrases. Topics that are covered include complementation and modification of adpositional phrases, as well as their predicative, attributive and adverbial uses. A separate chapter is devoted to the formation and the syntactic behavior of pronominal PPs like erop ‘on it’, which also includes a more general discussion of the syntax of so-called R-words like er ‘there’

Syntax of Dutch: Verbs and Verb Phrases. Volume 1

Syntax of Dutch: Verbs and Verb Phrases consists of three volumes. Volume 1 opens with a general introduction to verbs, including a review of various verb classifications and discussions on inflection, tense, mood, modality and aspect. This is followed by a comprehensive discussion of complementation (argument structure and verb frame alternations). Volume 2 continues the discussion of complementation, but is more specifically focused on clausal complements: the reader will find detailed discussions of finite and infinitival argument clauses, complex verb constructions and verb clustering. Volume 3 concludes with a description of adverbial modification and the overall structure of clauses in relation to, e.g., word order (verb placement, wh-movement. extraposition phenomena, scrambling, etc.)

Health Self-Management Applications in the Work Environment:The Effects on Employee Autonomy

Organizations increasingly use Health Self-Management Applications (HSMAs) that provide feedback information on health-related behaviors to their employees so that they can self-regulate a healthy lifestyle. Building upon Self-Determination Theory, this paper empirically investigates the basic assumption of HSMAs that their self-management feature provides employees with autonomy to self-regulate their health-related behavior. The two-phase experimental study contained a 4-weeks HSMA intervention in a healthcare work environment with a feedback factor (performance vs. developmental) and pretest and posttest measurements of participants' perceived autonomy. Following the experiment, interviews were conducted with users to gain an in-depth understanding of the moderating roles of feedback and BMI (a proxy for health) in the effects of HSMA on perceived autonomy. Findings reveal that the use of an HSMA does not significantly increase perceived autonomy, and may even reduce it under certain conditions. Providing additional developmental feedback generated more positive results than performance feedback alone. Employees with higher BMI perceived a greater loss of autonomy than employees with lower BMI. The reason for this is that higher-BMI employees felt external norms and standards for healthy behavior as more salient and experienced more negative emotions when those norms are not met, thereby making them more aware of their limitations in the pursuit of health goals

Protocol for the value of urodynamics prior to stress incontinence surgery (VUSIS) study: a multicenter randomized controlled trial to assess the cost effectiveness of urodynamics in women with symptoms of stress urinary incontinence in whom surgical treatment is considered

BACKGROUND: Stress urinary incontinence (SUI) is a common problem. In the Netherlands, yearly 64.000 new patients, of whom 96% are women, consult their general practitioner because of urinary incontinence. Approximately 7500 urodynamic evaluations and approximately 5000 operations for SUI are performed every year. In all major national and international guidelines from both gynaecological and urological scientific societies, it is advised to perform urodynamics prior to invasive treatment for SUI, but neither its effectiveness nor its cost-effectiveness has been assessed in a randomized setting. The Value of Urodynamics prior to Stress Incontinence Surgery (VUSIS) study evaluates the positive and negative effects with regard to outcome, as well as the costs of urodynamics, in women with symptoms of SUI in whom surgical treatment is considered. METHODS/DESIGN: A multicentre diagnostic cohort study will be performed with an embedded randomized controlled trial among women presenting with symptoms of (predominant) SUI. Urinary incontinence has to be demonstrated on clinical examination and/or voiding diary. Physiotherapy must have failed and surgical treatment needs to be under consideration. Patients will be excluded in case of previous incontinence surgery, in case of pelvic organ prolapse more than 1 centimeter beyond the hymen and/or in case of residual bladder volume of more than 150 milliliter on ultrasound or catheterisation. Patients with discordant findings between the diagnosis based on urodynamic investigation and the diagnosis based on their history, clinical examination and/or micturition diary will be randomized to operative therapy or individually tailored therapy based on all available information. Patients will be followed for two years after treatment by their attending urologist or gynaecologist, in combination with the completion of questionnaires. Six hundred female patients will be recruited for registration from approximately twenty-seven hospitals in the Netherlands. We aspect that one hundred and two women with discordant findings will be randomized. The primary outcome of this study is clinical improvement of incontinence as measured with the validated Dutch version of the Urinary Distress Inventory (UDI). Secondary outcomes of this study include costs, cure of incontinence as measured by voiding diary parameters, complications related to the intervention, re-interventions, and generic quality of life changes. TRIAL REGISTRATION: Clinical Trials NCT0081474

The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma

While comprehensive molecular profiling of histone H3.3 mutant pediatric high-grade glioma has revealed extensive dysregulation of the chromatin landscape, the exact mechanisms driving tumor formation remain poorly understood. Since H3.3 mutant gliomas also exhibit high levels of copy number alterations, we set out to address if the H3.3K27M oncohistone leads to destabilization of the genome. Hereto, we established a cell culture model allowing inducible H3.3K27M expression and observed an increase in mitotic abnormalities. We also found enhanced interaction of DNA replication factors with H3.3K27M during mitosis, indicating replication defects. Further functional analyses revealed increased genomic instability upon replication stress, as represented by mitotic bulky and ultrafine DNA bridges. This co-occurred with suboptimal 53BP1 nuclear body formation after mitosis in vitro, and in human glioma. Finally, we observed a decrease in ultrafine DNA bridges following deletion of the K27M mutant H3F3A allele in primary high-grade glioma cells. Together, our data uncover a role for H3.3 in DNA replication under stress conditions that is altered by the K27M mutation, promoting genomic instability and potentially glioma development