Research on non-timber forest products in selected countries in Southern and East Africa: themes, research issues, priorities and constraints

In this paper, the outcomes of a consultative meeting on non-timber forest products are reported and discussed. The meeting was organised by CIFOR and IUCN's Eastern Africa Regional Office on 15 and 16 September 1995 in Nairobi, Kenya, with the aim of discussing research priorities and information gaps related to non-timber forest products. The workshop brought together 11 people, representing forest research institutions, NGOs and other organisations involved in research related to non-timber forest products. The countries represented were Malawi, Kenya, Tanzania, Uganda and Zambia. During the meeting priority themes and issues were identified. These relate to management systems, policy and institutions, and community roles and social dimensions. Priority constraints include lack of personnel with appropriate expertise, inadequate financial resources, and insufficient data and information. A large number of solutions to overcome these constraints was discussed. It is concluded that since the main relevance of non-timber forest products in Southern and East Africa is at the local and subsistence level, an elaboration of the results of the meeting into workable research questions and methods should be defined at that level in an iterative process of action research, involving researchers and local users and managers of the forest. The meeting can be considered as a first, though authoritative, approximation of the needs in research on non-timber forest products in the region. It was agreed that elaboration of the findings of the meeting into specific action would be the only useful next step

Short-term LPS induces aortic valve thickening in ApoE*3Leiden mice

Background: Recently, it was shown that 12 weeks of lipopolysaccharide (LPS) administration to nonatherosclerotic mice induced thickening of the aortic heart valve (AV). Whether such effects may also occur even earlier is unknown. As most patients with AV stenosis also have atherosclerosis, we studied the short-term effect of LPS on the AVs in an atherosclerotic mouse model. Methods: ApoE*3Leiden mice, on an atherogenic diet, were injected intraperitoneally with either LPS or phosphate buffered saline (PBS), and sacrificed 2 or 15 days later. AVs were assessed for size, fibrosis, glycosaminoglycans (GAGs), lipids, calcium deposits, iron deposits and inflammatory cells. Results: LPS injection caused an increase in maximal leaflet thickness at 2 days (128.4 µm) compared to PBS-injected mice (67.8 µm; P = 0.007), whereas at 15 days this was not significantly different. LPS injection did not significantly affect average AV thickness on day 2 (37.8 µm), but did significantly increase average AV thickness at day 15 (41.6 µm; P = 0.038) compared to PBS-injected mice (31.7 and 32.3 µm respectively). LPS injection did not affect AV fibrosis, GAGs and lipid content. Furthermore, no calcium deposits were found. Iron deposits, indicative for valve haemorrhage, were observed in one AV of the PBS-injected group (a day 2 mouse; 9.1%) and in five AVs of the LPS-injected group (both day 2- and 15 mice; 29.4%). No significant differences in inflammatory cell infiltration were observed upon LPS injection. Conclusion: Short-term LPS apparently has the potential to increase AV thickening and haemorrhage. These results suggest that systemic inflammation can acutely compromise AV structure

Outcome of Nonsurgical Management of Extra-Abdominal, Trunk, and Abdominal Wall Desmoid-Type Fibromatosis: A Population-Based Study in the Netherlands

Contains fulltext : 196649.pdf (publisher's version ) (Open Access)Introduction: Nonsurgical management of patients with desmoid-type fibromatosis (DF) is increasing. This study tries to provide insight on type, usage, and outcome of first-line nonsurgical management strategies. Patients and Methods: From the Dutch Pathology Registry (PALGA), patients with extra-abdominal or trunk/abdominal wall DF, diagnosed between 1993 and 2013, were identified. First-line treatment was analyzed. Best response (BR) using RECIST criteria from start of treatment/surveillance until change of treatment or last follow-up was analyzed. Results: Ninety-one of the 1141 identified patients had first-line nonsurgical management. The percentage of patients treated nonsurgically increased from 0.6% in 1993-1998 to 12.8% in 2009-2013. Thirty-seven patients had surveillance (41%), 35 radiotherapy (38%), and 19 systemic treatment (21%). BR for surveillance was complete response (CR) in 2/37, partial response (PR) in 4/37, stable disease (SD) in 21/37, progressive disease (PD) in 5/37, and unknown in 5/37 patients. BR for radiotherapy was CR in 4/35, PR in 11/35, SD in 16/35, and unknown in 4/35. BR for systemic treatment was CR in 1/19, PR in 1/19, SD in 10/19, PD in 2/19, and unknown in 5/19. Totally, 91% of patients did not progress. Discussion: Given the low percentage (9%) of PD of nonsurgical management, these data can be used in shared decision making with the patient regarding optimal treatment