Short Report: Association Between Chloroquine and Amodiaquine Resistance and Allelic Variation in the Plasmodium Falciparum Multiple Drug Resistance 1 Gene and the Chloroquine Resistance Transporter Gene in Isolates from the Upper Nile in Southern Sudan.

Amodiaquine, a 4-aminoquinoline compound, is being considered as an alternative to chloroquine and pyrimethamine/sulfadoxine where resistance in Plasmodium falciparum to both drugs has been selected. Although amodiaquine is more potent than chloroquine, its effectiveness is reduced in areas where chloroquine resistance is high. We report an association of the P. falciparum chloroquine resistance transporter (pfcrt) gene and the P. falciparum multiple drug resistance 1 (pfmdr1) gene, two chloroquine resistance markers, with chloroquine and amodiaquine efficacy in vivo in southern Sudan. The data show that the allele of the pfcrt gene with a lysine to threonine change at codon 76 is strongly associated with both chloroquine and amodiaquine resistance. No such association was observed with the pfmdr1 gene

Chromosomal breakpoints in colorectal cancer

Meijer, G.A. [Promotor]Fijneman, R.J.A. [Copromotor

Simplex solid states of SU(N) quantum antiferromagnets

I define a set of wavefunctions for SU(N) lattice antiferromagnets, analogous to the valence bond solid states of Affleck, Kennedy, Lieb, and Tasaki (AKLT), in which the singlets are extended over N-site simplices. As with the valence bond solids, the new simplex solid (SS) states are extinguished by certain local projection operators, allowing us to construct Hamiltonians with local interactions which render the SS states exact ground states. Using a coherent state representation, we show that the quantum correlations in each SS state are calculable as the finite temperature correlations of an associated classical model, with N-spin interactions, on the same lattice. In three and higher dimensions, the SS states can spontaneously break SU(N) and exhibit N-sublattice long-ranged order, as a function of a discrete parameter which fixes the local representation of SU(N). I analyze this transition using a classical mean field approach. For N>2 the ordered state is selected via an "order by disorder" mechanism. As in the AKLT case, the bulk representations fractionalize at an edge, and the ground state entropy is proportional to the volume of the boundary.Comment: 14 pages, 8 figures, minor typos correcte

Fundamental analysis of the failure of polymer-based fiber reinforced composites

A mathematical model is described which will permit predictions of the strength of fiber reinforced composites containing known flaws to be made from the basic properties of their constituents. The approach was to embed a local heterogeneous region (LHR) surrounding the crack tip into an anisotropic elastic continuum. The model should (1) permit an explicit analysis of the micromechanical processes involved in the fracture process, and (2) remain simple enough to be useful in practical computations. Computations for arbitrary flaw size and orientation under arbitrary applied load combinations were performed from unidirectional composites with linear elastic-brittle constituent behavior. The mechanical properties were nominally those of graphite epoxy. With the rupture properties arbitrarily varied to test the capability of the model to reflect real fracture modes in fiber composites, it was shown that fiber breakage, matrix crazing, crack bridging, matrix-fiber debonding, and axial splitting can all occur during a period of (gradually) increasing load prior to catastrophic fracture. The computations reveal qualitatively the sequential nature of the stable crack process that precedes fracture

Personalized Empathic Computing (PEC)

Until a decade ago, computers were only used by experts, for professional purposes solely. Nowadays, the personal computer (PC) is standard equipment in most western housekeepings and is used to gather information, play games, communicate, etc. In parallel, users' expectations increase and, consequently, PCs are more and more adapted to our needs. The next phase in PC evolution is Personalized Empathic Computing (PEC). When thinking of PEC, questions emerge such as: Who is the user and how to model his or her characteristics? In addition, both possibilities and constraints of technology have to be taken into account. To unravel human emotional state, psychophysiological techniques are employed. Audio and visual information processing is needed to handle the multimedia input. Virtual Reality can be employed to realize high level interaction between users and PEC systems. The realization of PEC requires the cooperation among a broad range of disciplines; e.g., psychology, physiology, computer science, agent technology, interface design, and multimedia analysis. All will be illustrated by running projects, industrial applications, and the latest scientific research. Both the strength and the limitations of current state-of-the-art techniques will be indicated. With that we will look forward, to the future, which is not that far away anymore ..

Incremental Distance Transforms (IDT)

A new generic scheme for incremental implementations of distance transforms (DT) is presented: Incremental Distance Transforms (IDT). This scheme is applied on the cityblock, Chamfer, and three recent exact Euclidean DT (E2DT). A benchmark shows that for all five DT, the incremental implementation results in a significant speedup: 3.4×−10×. However, significant differences (i.e., up to 12.5×) among the DT remain present. The FEED transform, one of the recent E2DT, even showed to be faster than both city-block and Chamfer DT. So, through a very efficient incremental processing scheme for DT, a relief is found for E2DT’s computational burden