1,689 research outputs found

    The Wagner Act and the Question of Workplace Representation

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    Paper_Brody_011094.pdf: 2455 downloads, before Oct. 1, 2020

    Elementary solution to the time-independent quantum navigation problem

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    A quantum navigation problem concerns the identification of a time-optimal Hamiltonian that realizes a required quantum process or task, under the influence of a prevailing ‘background’ Hamiltonian that cannot be manipulated. When the task is to transform one quantum state into another, finding the solution in closed form to the problem is nontrivial even in the case of timeindependent Hamiltonians. An elementary solution, based on trigonometric analysis, is found here when the Hilbert space dimension is two. Difficulties arising from generalizations to higher-dimensional systems are discussed

    From the Desktop to the Cloud: Leveraging Hybrid Storage Architectures in Your Repository

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    4th International Conference on Open RepositoriesThis presentation was part of the session : Conference PresentationsDate: 2009-05-19 01:00 PM – 02:30 PMRepositories collect and manage data holdings using a storage device. Mainly this has been a local file system, but recently attempts have been made at using open storage products and cloud storage solutions, such as Sun's Honeycomb and Amazon S3 respectively. Each of these solutions has their own pros and cons but There are advantages in adopting a hybrid model for repository storage, combining the relative strengths of each one in a policy-determined model. In this paper we present an implementation of a repository storage layer which can dynamically handle and manage a hybrid storage systemJoint Information Systems Committee (JISC

    Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities

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    Alzheimer\u27s disease (AD) is a neurodegenerative disorder characterized pathologically by progressive neuronal loss, extracellular plaques containing the amyloid-β (Aβ) peptides, and neurofibrillary tangles composed of hyperphosphorylated tau proteins. Aβ is thought to act upstream of tau, affecting its phosphorylation and therefore aggregation state. One of the major risk factors for AD is traumatic brain injury (TBI). Acute intra-axonal Aβ and diffuse extracellular plaques occur in ∼30% of human subjects after severe TBI. Intra-axonal accumulations of tau but not tangle-like pathologies have also been found in these patients. Whether and how these acute accumulations contribute to subsequent AD development is not known, and the interaction between Aβ and tau in the setting of TBI has not been investigated. Here, we report that controlled cortical impact TBI in 3xTg-AD mice resulted in intra-axonal Aβ accumulations and increased phospho-tau immunoreactivity at 24 h and up to 7 d after TBI. Given these findings, we investigated the relationship between Aβ and tau pathologies after trauma in this model by systemic treatment of Compound E to inhibit γ-secretase activity, a proteolytic process required for Aβ production. Compound E treatment successfully blocked posttraumatic Aβ accumulation in these injured mice at both time points. However, tau pathology was not affected. Our data support a causal role for TBI in acceleration of AD-related pathologies and suggest that TBI may independently affect Aβ and tau abnormalities. Future studies will be required to assess the behavioral and long-term neurodegenerative consequences of these pathologies

    SPECIAL PROJECT: LABOR-MANAGEMENT COOPERATION

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    Much of the current debate concerning labor-management cooperative efforts centers on section 8(a)(2) of the National Labor Relations Act (the Act), which makes dominating, interfering with, or contributing to the formation or administration of any labor organization an unfair labor practice. On its face, this section may inhibit cooperative efforts through a prohibition of management support for employee organizations. The effect of section 8(a)(2), however, need not be so restrictive because of the Act\u27s underlying concern for the effectuation of employee freedom of choice. A concern for employee free choice provides a means for permitting positive cooperative efforts, consistent with trends in labor-management relations, while preventing the abuses feared by the drafters of the Act. An examination of the legislative history surrounding the passage of the Act in 19354 is crucial to understanding section 8(a)(2) because much of the debate on the original Act 5 centered on what eventually became section 8(a)(2) . Although the stated purpose of the 1935 Act was [t]o promote equality of bargaining power between employers and employees [and] to diminish the causes of labor disputes, \u27 the discussion surrounding the formation of this Act reveals that the controlling intent of the Act\u27s drafters was to eliminate the company-dominated union. To effectuate their goals, the drafters structured the Act in a way that forces labor and management into adversarial positions. Contrary to the contentions of later cases, the Act\u27s drafters did not intend to promote cooperation between labor and management. The legislative history indicates that the drafters were more concerned with cooperation among labor itself,\u27 with the belief that if employees could in-crease their power through cooperation with each other, then labor could bargain as an equal with management

    The Legal Aspects of Oil Shale Development [outline]

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    Classification of traumatic brain injury for targeted therapies

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