731 research outputs found
Theoretical He I Emissivities in the Case B Approximation
We calculate the He I case B recombination cascade spectrum using improved
radiative and collisional data. We present new emissivities over a range of
electron temperatures and densities. The differences between our results and
the current standard are large enough to have a significant effect not only on
the interpretation of observed spectra of a wide variety of objects but also on
determinations of the primordial helium abundance.Comment: Accepted to ApJ
Improving Predictions for Helium Emission Lines
We have combined the detailed He I recombination model of Smits with the
collisional transitions of Sawey & Berrington in order to produce new accurate
helium emissivities that include the effects of collisional excitation from
both the 2 (3)S and 2 (1) S levels. We present a grid of emissivities for a
range of temperature and densities along with analytical fits and error
estimates.
Fits accurate to within 1% are given for the emissivities of the brightest
lines over a restricted range for estimates of primordial helium abundance. We
characterize the analysis uncertainties associated with uncertainties in
temperature, density, fitting functions, and input atomic data. We estimate
that atomic data uncertainties alone may limit abundance estimates to an
accuracy of 1.5%; systematic errors may be greater than this. This analysis
uncertainty must be incorporated when attempting to make high accuracy
estimates of the helium abundance. For example, in recent determinations of the
primordial helium abundance, uncertainties in the input atomic data have been
neglected.Comment: ApJ, accepte
Achieving orphan designation for placental insufficiency: annual incidence estimations in Europe
Objective
To determine whether a novel therapy for placental insufficiency could achieve orphan drug status by estimating the annual incidence of placental insufficiency, defined as an estimated fetal weight below the 10th centile in the presence of abnormal umbilical artery Doppler velocimetry, per 10 000 European Union (EU ) population as part of an application for European Medicines Agency (EMA ) orphan designation.
Design
Incidence estimation based on literature review and published national and EU statistics.
Setting and population
European Union.
Methods
Data were drawn from published literature, including national and international guidelines, international consensus statements, cohort studies and randomised controlled trials, and published national and EU statistics, including birth rates and stillbirth rates. Rare disease databases were also searched.
Results
The proportion of affected pregnancies was estimated as 3.17% (95% CI 2.93â3.43%), using a weighted average of the results from two cohort studies. Using birth rates from 2012 and adjusting for a pregnancy loss rate of 1/100 gave an estimated annual incidence of 3.33 per 10 000 EU population (95% CI 3.07â3.60 per 10 000 EU population). This fell below the EMA threshold of 5 per 10 000 EU population.
Conclusions
Maternal vascular endothelial growth factor gene therapy for placental insufficiency was granted EMA orphan status in 2015 after we demonstrated that it is a rare, lifeâthreatening or chronically debilitating and currently untreatable disease. Developers of other potential obstetric therapies should consider applying for orphan designation, which provides financial and regulatory benefits
Temperature Fluctuations and Abundances in HII Galaxies
There is evidence for temperature fluctuations in Planetary Nebulae and in
Galactic HII regions. If such fluctuations occur in the low-metallicity,
extragalactic HII regions used to probe the primordial helium abundance, the
derived 4He mass fraction, Y_P, could be systematically different from the true
primordial value. For cooler, mainly high-metallicity HII regions the derived
helium abundance may be nearly unchanged but the oxygen abundance could have
been seriously underestimated. For hotter, mainly low-metallicity HII regions
the oxygen abundance is likely accurate but the helium abundance could be
underestimated. The net effect is to tilt the Y vs. Z relation, making it
flatter and resulting in a higher inferred Y_P. Although this effect could be
large, there are no data which allow us to estimate the size of the temperature
fluctuations for the extragalactic HII regions. Therefore, we have explored
this effect via Monte Carlos in which the abundances derived from a fiducial
data set are modified by \Delta-T chosen from a distribution with 0 < \Delta-T
< \Delta-T_max where \Delta-T_max is varied from 500K to 4000K. It is
interesting that although this effect shifts the locations of the HII regions
in Y vs. O/H plane, it does not introduce any significant additional
dispersion.Comment: 11 pages, 9 postscript figures; submitted to the Ap
Detection of a Lyman-alpha Emission-Line Companion to the z=4.69 QSO BR1202-0725
We report the detection of a nearby emission-line companion to the z=4.695
quasar BR1202-0725. Deep narrow-band exposures on this field from the UH 2.2 m
show a Ly alpha flux of 1.5\times\ten{-16} ergs cm^{-2} s^{-1}. High-resolution
HST WFC2 imaging in the F814W filter band shows continuum structure near the
emission position, at 2.6" NW of the quasar, corresponding to a projected
separation of ~7.5 h^{-1} kpc for \qnought=0.5, where h=\hnought/100\kms
Mpc^{-1}. We discuss possible explanations for the combined line and color
properties. The ionization is most likely produced by the quasar, but if due to
underlying star formation would require a star formation rate of ~7 h^2 solar
masses per yr.Comment: 12 pages LaTeX (aastex4.0 macros: aasms4.sty, flushrt.sty) plus 3
figures. To appear in the Astrophysical Journal Letters. Typo in original
submission ("2" should have been "7" in luminosity: 7e42 h^{-2} ergs and in
the star formation rate: 7 h^{-2} \msun per yr). Resubmitted with figure
Analysis of model rotor blade pressures during parallel interaction with twin vortices
This paper presents and provides analysis of unsteady surface pressures measured on a model rotor blade as the blade experienced near parallel blade vortex interaction with a twin vortex system. To provide a basis for analysis, the vortex system was characterized by hot-wire measurements made in the interaction plane but in the absence of the rotor. The unsteady pressure response resulting from a single vortex interaction is then presented to provide a frame of reference for the twin vortex results. A series of twin vortex interaction cases are then presented and analyzed. It is shown that the unsteady blade pressures and forces are very sensitive to the inclination angle and separation distance of the vortex pair. When the vortex cores lie almost parallel to the blade chord, the interaction is characterized by a two-stage response associated with the sequential passage of the two cores. Conversely, when the cores lie on a plane that is almost perpendicular to the blade chord, the response is similar to that of a single vortex interaction. In all cases, the normal force response is consistent with the distribution of vertical velocity in the flow field of the vortex system. The pitching moment response, on the other hand, depends on the localized suction associated with the vortex cores as they traverse the blade chord
The Chemical Composition of the Small Magellanic Cloud H II Region NGC 346 and the Primordial Helium Abundance
Spectrophotometry in the 3400-7400 range is presented for 13 areas of the
brightest H II region in the SMC: NGC 346. The observations were obtained at
CTIO with the 4-m telescope. Based on these observations its chemical
composition is derived. The helium and oxygen abundances by mass are given by:
Y(SMC)=0.2405+-0.0018 and O(SMC)=0.00171+-0.00025. From models and observations
of irregular and blue compact galaxies it is found that dY/dO=3.5+-0.9 and
consequently that the primordial helium abundance by mass is given by:
Yp=0.2345+-0.0026 (1-sigma). This result is compared with values derived from
Big Bang nucleosynthesis, and with other determinations of Yp.Comment: 32 pages + 5 figures Referee Revised Versio
Spectrophotometric Observations of Blue Compact Dwarf Galaxies: Mrk 370
We present results from a detailed spectrophotometric analysis of the blue
compact dwarf galaxy (BCD) Mrk 370, based on deep UBVRI broad-band and Halpha
narrow-band observations, and long-slit and two-dimensional spectroscopy of its
brightest knots. The spectroscopic data are used to derive the internal
extinction, and to compute metallicities, electronic density and temperature in
the knots. By subtracting the contribution of the underlying older stellar
population, modeled by an exponential function, removing the contribution from
emission lines, and correcting for extinction, we can measure the true colors
of the young star-forming knots. We show that the colors obtained this way
differ significantly from those derived without the above corrections, and lead
to different estimates of the ages and star-forming history of the knots. Using
predictions of evolutionary synthesis models, we estimate the ages of both the
starburst regions and the underlying stellar component. We found that we can
reproduce the colors of all the knots with an instantaneous burst of star
formation and the Salpeter initial mass function with an upper mass limit of
100 solar masses. The resulting ages range between 3 and 6 Myrs. The colors of
the low surface brightness component are consistent with ages larger than 5
Gyr. The kinematic results suggest ordered motion around the major axis of the
galaxy.Comment: 26 pages with 14 figures; accepted for publication in Ap
Management and implications of severe COVID-19 in pregnancy in the UK: data from the UK Obstetric Surveillance System national cohort
INTRODUCTION: There is a lack of population level data on risk factors and impact of severe COVID-19 in pregnancy. The aims of this study were to determine the characteristics, and maternal and perinatal outcomes associated with severe COVID-19 in pregnancy compared with those with mild and moderate COVID-19 and to explore the impact of timing of birth. MATERIAL AND METHODS: This was a secondary analysis of a national, prospective cohort study. All pregnant women admitted to hospital in the UK with symptomatic SARS-CoV-2 from March 1, 2020 to October 31, 2021 were included. The severity of maternal infection (need for high flow or invasive ventilation, intensive care admission or died), pregnancy and perinatal outcomes, and the impact of timing of birth were analyzed using multivariable logistic regression. RESULTS: Of 4436 pregnant women, 13.9% (n = 616) had severe infection. Women with severe infection were more likely to be aged â„30 years (adjusted odds ratio [aOR] aged 30-39 1.48, 95% confidence interval [CI] 1.20-1.83), be overweight or obese (aOR 1.73, 95% CI 1.34-2.25 and aOR 2.52 95% CI 1.97-3.23, respectively), be of mixed ethnicity (aOR 1.93, 95% CI 1.17-3.21) or have gestational diabetes (aOR 1.43, 95% CI 1.09-1.87) compared with those with mild or moderate infection. Women with severe infection were more likely to have a pre-labor cesarean birth (aOR 8.84, 95% CI 6.61-11.83), a very or extreme preterm birth (28-31+ weeks' gestation, aOR 18.97, 95% CI 7.78-14.85; <28 weeks' gestation, aOR 12.35, 95% CI 6.34-24.05) and their babies were more likely to be stillborn (aOR 2.51, 95% CI 1.35-4.66) or admitted to a neonatal unit (aOR 11.61, 95% CI 9.28-14.52). Of 112 women with severe infection who were discharged and gave birth at a later admission, the majority gave birth â„36 weeks (85.7%), noting that three women in this group (2.7%) had a stillbirth. CONCLUSIONS: Severe COVID-19 in pregnancy increases the risk of adverse outcomes. Information to promote uptake of vaccination should specifically target those at greatest risk of severe outcomes. Decisions about timing of birth should be informed by multidisciplinary team discussion; however, our data suggest that women with severe infection who do not require early delivery have mostly good outcomes but that those with severe infection at term may warrant rapid delivery
Severity of maternal infection and perinatal outcomes during periods of SARS-CoV-2 wildtype, alpha, and delta variant dominance in the UK: prospective cohort study
OBJECTIVE: To compare the severity of maternal infection and perinatal outcomes during periods in which wildtype, alpha variant, and delta variant of SARS-CoV-2 were dominant in the UK. DESIGN: Prospective cohort study. SETTING: 194 obstetric units across the UK, during the following periods: between 1 March and 30 November 2020 (wildtype dominance), between 1 December 2020 and 15 May 2021 (alpha variant dominance), and between 16 May and 31 October 2021 (delta variant dominance). PARTICIPANTS: 4436 pregnant women admitted to hospital with covid-19 related symptoms. MAIN OUTCOME MEASURES: Moderate to severe maternal SARS-CoV-2 infection (indicated by any of the following: oxygen saturation <95% on admission, need for oxygen treatment, evidence of pneumonia on imaging, admission to intensive care, or maternal death), and pregnancy and perinatal outcomes (including mode and gestation of birth, stillbirth, live birth, admission to neonatal intensive care, and neonatal death). RESULTS: 1387, 1613, and 1436 pregnant women were admitted to hospital with covid-19 related symptoms during the wildtype, alpha, and delta dominance periods, respectively; of these women, 340, 585, and 614 had moderate to severe infection, respectively. The proportion of pregnant women admitted with moderate to severe infection increased during the subsequent alpha and delta dominance periods, compared with the wildtype dominance period (wildtype 24.5% v alpha 36.2% (adjusted odds ratio 1.98, 95%âconfidence interval 1.66% to 2.37%); wildtype 24.5% v delta 42.8% (2.66, 2.21 to 3.20)). Compared with the wildtype dominance period, women admitted during the alpha dominance period were significantly more likely to have pneumonia, require respiratory support, and be admitted to intensive care; these three risks were even greater during the delta dominance period (wildtype v delta: pneumonia, adjusted odds ratio 2.52, 95% confidence interval 2.06 to 3.09; respiratory support, 1.90, 1.52 to 2.37; and intensive care, 2.71, 2.06 to 3.56). Of 1761 women whose vaccination status was known, 38 (2.2%) had one dose and 16 (1%) had two doses before their diagnosis (of whom 14 (88%) had mild infection). The proportion of women receiving drug treatment for SARS-CoV-2 management was low, but did increase between the wildtype dominance period and the alpha and delta dominance periods (10.4% wildtype v 14.9% alpha (2.74, 2.08 to 3.60); 10.4% wildtype v 13.6% delta (2.54, 1.90 to 3.38)). CONCLUSIONS: While limited by the absence of variant sequencing data, these findings suggest that during the periods when the alpha and delta variants of SARS-CoV-2 were dominant, covid-19 was associated with more severe maternal infection and worse pregnancy outcomes than during the wildtype dominance period. Most women admitted with SARS-CoV-2 related symptoms were unvaccinated. Urgent action to prioritise vaccine uptake in pregnancy is essential. STUDY REGISTRATION: ISRCTN40092247
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