Unique precursors for the mesenchymal cells involved in injury response and fibrosis

We investigated an alternative pathway for emergence of the mesenchymal cells involved in epithelial sheet wound healing and a source of myofibroblasts that cause fibrosis. Using a mock cataract surgery model, we discovered a unique subpopulation of polyploid mesenchymal progenitors nestled in small niches among lens epithelial cells that expressed the surface antigen G8 and mRNA for the myogenic transcription factor MyoD. These cells rapidly responded to wounding of the lens epithelium with population expansion, acquisition of a mesenchymal phenotype, and migration to the wound edges where they regulate the wound response of the epithelium. These mesenchymal cells also were a principal source of myofibroblasts that emerged following lens injury and were responsible for fibrotic disease of the lens that occurs following cataract surgery. These studies provide insight into the mechanisms of wound-healing and fibrosis

Future scenarios and the impact of socio-technologies (a transnational perspective from the global ‘north’)

The article opens by briefly reviewing studies of sexuality in and around organizations from the 1970s. These studies showed considerable theoretical, empirical and conceptual development, as in the concept of organization sexuality. Building on this, the article’s first task is to analyse alternative future scenarios for organization sexualities, by way of changing intersections of gender, sexuality and organizational forms. Possible gendered future scenarios are outlined based on, first, gender equality/inequality and, second, gender similarity/difference between women, men and further genders: hyper-patriarchy scenario—men and women becoming more divergent; with greater inequality; late capitalist gender scenario—genders becoming more convergent, with greater inequality; bi-polar scenario—men and women becoming more divergent, with greater equality; postgender scenario—genders becoming more convergent, with greater equality. Somewhat similar scenarios for organization sexualities are elaborated in terms of gender/sexual equality and inequality and sexual/gender similarity and difference: heteropatriarchies scenario—greater sexual/gender difference and greater sexual or sexual/gender inequality; late capitalist sexual scenario—greater sexual/gender similarity and greater sexual or gender/sexual inequality; sexual differentiation scenario—greater sexual/gender difference and greater sexual or sexual/gender equality; sexual blurring scenario—greater sexual/gender similarity and greater sexual or sexual/gender equality. The article’s second task is to addresses the impact of globalizations and transnationalizations, specifically information and communication technologies and other socio-technologies, for future scenarios of organization sexualities. The characteristic affordances of ICTs—technological control, virtual reproducibility, conditional communality, unfinished undecidability—are mapped onto the four scenarios above and the implications outlined