Maternal COVID-19 causing intrauterine foetal demise with microthrombotic placental insufficiency: a case report

BACKGROUND: Pregnant women have an increased risk of getting infected with SARS-CoV-2 and are more prone to severe illness. Data on foetal demise in affected pregnancies and its underlying aetiology is scarce and pathomechanisms remain largely unclear. CASE: Herein we present the case of a pregnant woman with COVID-19 and intrauterine foetal demise. She had no previous obstetric or gynaecological history, and presented with mild symptoms at 34 + 3 weeks and no signs of foetal distress. At 35 + 6 weeks intrauterine foetal death was diagnosed. In the placental histopathology evaluation, we found inter- and perivillous fibrin depositions including viral particles in areas of degraded placental anatomy without presence of viral entry receptors and SARS-CoV-2 infection of the placenta. CONCLUSION: This case demonstrates that maternal SARS-CoV-2 infection in the third trimester may lead to an unfavourable outcome for the foetus due to placental fibrin deposition in maternal COVID-19 disease possibly via a thrombogenic microenvironment, even when the foetus itself is not infected

Friedensengagement und Leistungsverhalten sozialistischer Produzenten Studie

Freie Universitaet Berlin, Zentralinstitut 6 03/88 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

The highly conserved FOXJ1 target CFAP161 is dispensable for motile ciliary function in mouse and <em>Xenopus</em>.

Cilia are protrusions of the cell surface and composed of hundreds of proteins many of which are evolutionary and functionally well conserved. In cells assembling motile cilia the expression of numerous ciliary components is under the control of the transcription factor FOXJ1. Here, we analyse the evolutionary conserved FOXJ1 target CFAP161 in Xenopus and mouse. In both species Cfap161 expression correlates with the presence of motile cilia and depends on FOXJ1. Tagged CFAP161 localises to the basal bodies of multiciliated cells of the Xenopus larval epidermis, and in mice CFAP161 protein localises to the axoneme. Surprisingly, disruption of the Cfap161 gene in both species did not lead to motile cilia-related phenotypes, which contrasts with the conserved expression in cells carrying motile cilia and high sequence conservation. In mice mutation of Cfap161 stabilised the mutant mRNA making genetic compensation triggered by mRNA decay unlikely. However, genes related to microtubules and cilia, microtubule motor activity and inner dyneins were dysregulated, which might buffer the Cfap161 mutation

Actinomycosis of the larynx

The European Values Study (EVS) was first conducted in 1981 and then repeated in 1990, 1999, 2008, and 2017, with the aim of providing researchers with data to investigate whether European individual and social values are changing and to what degree. The EVS is traditionally carried out as a probability-based face-to-face survey that takes around 1 hour to complete. In recent years, large-scale population surveys such as the EVS have been challenged by decreasing response rates and increasing survey costs. In the light of these challenges, six countries that participated in the last wave of the EVS tested the application of self-administered mixed-modes (Denmark, Finland, Germany, Iceland, the Netherlands, and Switzerland). With the present data brief, we will introduce researchers to the latest wave of the EVS, the implemented mode experiments, and the EVS data releases. In our view, it is pivotal for data use in substantive research to make the reasoning behind design changes and country-specific implementations transparent as well as to highlight new research opportunities

„Second order“-Effekte und Determinanten der individuellen Wahlentscheidung bei Landtagswahlen: Eine Analyse des Wahlverhaltens im deutschen Mehrebenensystem

Studies on mid-term elections in multi-level systems show that it is used by the voters to get in on the crucial - punish ruling party level - mostly national. This applies also tend to state elections in the Federal Republic of Germany. With few exceptions, empirical studies to test this relationship using aggregate data. In this paper we argue that on an aggregate level often observable "second-order" effect should be the extent attributable to the individual choice decision, as should have a smaller effect on the choice of participating in the federal government parties "classical" determinants of voting behavior in state elections the greater the distance to the next federal election time. Moreover, it is argued that interest should select oriented gain importance when the result of a state election has a significant impact on the distribution of seats in the Bundesrat. We test these arguments using a data set that includes all state election studies 1985 and 2009. The analyzes show - even if one controls for a "individualization" of voting behavior - no empirical evidence for the expectations at the individual level is not a "second-order" effect nor a federal political penetration of voting behavior in state elections observable