CC Chemokine Receptor 7–dependent and –independent Pathways for Lymphocyte Homing: Modulation by FTY720

Cognate interaction of chemokine receptor CCR7 on lymphocytes with its ligands CCL19 and CCL21 expressed on high endothelial venules (HEVs) is essential for effective migration of T and B cells across HEVs into secondary lymphoid organs. Plt mice, which lack expression of CCL19 and CCL21-ser, both ligands for CCR7 on HEVs, as well as CCR7-deficient mice, have a defective cell migration and reduced homing of lymphocytes. FTY720, a novel immunosuppressant, causes a reduction of lymphocytes in peripheral blood and tissues and their sequestration into lymphoid tissues. In this study we demonstrate that FTY720 rescues the homing defect in both CCR7−/− mice and plt mice. After FTY720 treatment, the number of CD4+ and CD8+ T cells as well as B cells in peripheral blood is reduced while pertussis toxin–sensitive homing into peripheral lymph nodes, mesenteric lymph node, and Peyer's patches is increased. Immunohistology demonstrates that FTY720 enables these cells to enter lymphoid tissue through HEVs. Thus, our data suggest an alternative G-αi-dependent, CCR7-CCL19/CCL21-independent mechanism for lymphocyte homing through HEVs which is strongly augmented in the presence of FTY720

Driven into paradise: the musical migration from Nazi Germany to the United States

The forced migration of artists and scholars from Nazi Germany is a compelling and often wrenching story. The story is twofold, of impoverishment for the countries the musicians left behind and enrichment for the United States. The latter is the focus of this eminent collection, which approaches the subject from diverse perspectives, including documentary-style newspaper accounts and an exploration of Walt Whitman's poetry in the work of Paul Hindemith and Kurt Weill.The flood of musical migration from Germany and Austria from 1933 to 1944 had a lasting impact. Hundreds of musicians and musicologists came to the United States and remained here, and the shaping power of their talents is incalculable. Several essays provide firsthand insights into aspects of American cultural history to which these émigrés made essential contributions as conductors, professors, and composers; other essays tell of the traumatic experience of being exiled and the difficulties of finding one's way in a foreign country. While the migration infused the U.S. with a distinctly European musical awareness, at the same time the status and authority of its participants tended to intervene in the development of a genuinely American cultural voice. The story of the unprecedented migration that resulted from Nazism has many dimensions, and Driven Into Paradise illuminates them in deeply human terms