The effects of advances in data processing and communications on the pattern of information-handling-business activity

Thesis (M.C.P.)--Massachusetts Institute of Technology, Dept. of City and Regional Planning, 1959.Includes bibliographical references (leaves 97-103).by Henry S. Brinkers.M.C.P

Decision-making: creativity, judgment, and systems

(print) x, 276 p. : ill. : 24 cmThe essays assembled in this volume were prepared by the authors for presentation on the campus of the Ohio State University at the Thomas A. Boyd interdisciplinary conference on decision-making aids. Through the financial support of the College of Engineering, the Thomas A. Boyd Lecture Fund, and the School of Architecture, the conference was established as a means for bringing together an interdisciplinary group of scientists and scholars for a wide-ranging discussion of the many aspects of emerging decision-aid research and applications along with their implications for professional activities and professional education. Consonant with the excellence and achievement stimulated by Thomas A. Boyd's support for higher education, the conference and the papers presented in this volume are dedicated to the advancement of the use of scientific methods for decision-making within the several disciplines concerned with enhancing environment and the well-being of people.Preface. p.ix -- Introduction. p.3 -- PART 1: Decision-making strategies. -- Personalistic decision theory: exposition and critique. p.19 -- The Study of collective decisions. p.42 -- PART 2: Decision-making aids -- Information science as an aid to decision-making. p.69 -- Toward a working theory of automated design. p.85 -- The Generation of form by geometric methods. p.112 -- PART 3: Decision aid applications -- Decision aids for the planning and development of university facilities. p.127 -- Analytic approaches to facility layout and design. p.137 -- Development action sequencing under highly constrained conditions. p.147 -- Adaptive diagnosis of problems. p.157 -- PART 4: Human creativity and judgment -- Managing visual information. p.173 -- Matching decision aids with intuitive styles. p.190 -- Conceptual models in design. p.205 -- PART 5: Implications -- Who looks at the whole system? p.223 -- Decision aids: needs and prospects. p.247 -- Epilogue. p.261 -- Notes on the contribution. p.265 -- Index. p.26

International round-robin experiment for angle-resolved light scattering measurement

International audienc

Monitoring the Size and Lateral Dynamics of ErbB1 Enriched Membrane Domains through Live Cell Plasmon Coupling Microscopy

To illuminate the role of the spatial organization of the epidermal growth factor receptor (ErbB1) in signal transduction quantitative information about the receptor topography on the cell surface, ideally on living cells and in real time, are required. We demonstrate that plasmon coupling microscopy (PCM) enables to detect, size, and track individual membrane domains enriched in ErbB1 with high temporal resolution. We used a dendrimer enhanced labeling strategy to label ErbB1 receptors on epidermoid carcinoma cells (A431) with 60 nm Au nanoparticle (NP) immunolabels under physiological conditions at 37°C. The statistical analysis of the spatial NP distribution on the cell surface in the scanning electron microscope (SEM) confirmed a clustering of the NP labels consistent with a heterogeneous distribution of ErbB1 in the plasma membrane. Spectral shifts in the scattering response of clustered NPs facilitated the detection and sizing of individual NP clusters on living cells in solution in an optical microscope. We tracked the lateral diffusion of individual clusters at a frame rate of 200 frames/s while simultaneously monitoring the configurational dynamics of the clusters. Structural information about the NP clusters in their membrane confinements were obtained through analysis of the electromagnetic coupling of the co-confined NP labels through polarization resolved PCM. Our studies show that the ErbB1 receptor is enriched in membrane domains with typical diameters in the range between 60–250 nm. These membrane domains exhibit a slow lateral diffusion with a diffusion coefficient of  = |0.0054±0.0064| µm2/s, which is almost an order of magnitude slower than the mean diffusion coefficient of individual NP tagged ErbB1 receptors under identical conditions

All that glitters is gold: Nucleic acid detection using tethered gold

Imaging Science & TechnologyApplied Science