Clinical and Biochemical Aspects of Gestational Diabetes Mellitus

This thesis seeks to explore the overall management of gestational diabetes mellitus. The _first_ aim is to investigate biomarkers and risk stratification. Which potential biomarkers can be used in the prediction of GDM? Is ghrelin a useful biomarker? The _second_ aim is to evaluate current management of GDM. Is the current national screening and treatment guideline effective in reducing GDM related complications? What is the role of blinded continuous glucose monitoring in treatment monitoring? The _third_ aim is to study the adherence to long-term diabetes screening recommendations in women with GDM

On the effects of the magnetic field and the isotopic substitution upon the infrared absorption of manganites

Employing a variational approach that takes into account electron-phonon and magnetic interactions in $La_{1-x}A_xMnO_3$ perovskites with $0<x<0.5$, the effects of the magnetic field and the oxygen isotope substitution on the phase diagram, the electron-phonon correlation function and the infrared absorption at $x=0.3$ are studied. The lattice displacements show a strong correlation with the conductivity and the magnetic properties of the system. Then the conductivity spectra are characterized by a marked sensitivity to the external parameters near the phase boundary.Comment: 10 figure

Taking off the square root of Nambu-Goto action and obtaining Filippov-Lie algebra gauge theory action

We propose a novel prescription to take off the square root of Nambu-Goto action for a p-brane, which generalizes the Brink-Di Vecchia-Howe-Tucker or also known as Polyakov method. With an arbitrary decomposition as d+n=p+1, our resulting action is a modified d-dimensional Polyakov action which is gauged and possesses a Nambu n-bracket squared potential. We first spell out how the (p+1)-dimensional diffeomorphism is realized in the lower dimensional action. Then we discuss a possible gauge fixing of it to a direct product of $d$-dimensional diffeomorphism and n-dimensional volume preserving diffeomorphism. We show that the latter naturally leads to a novel Filippov-Lie n-algebra based gauge theory action in d-dimensions.Comment: 1+13 pages, No figure; Expanded, published version. Title change

Noncommutative Fluids

We review the connection between noncommutative gauge theory, matrix models and fluid mechanical systems. The noncommutative Chern-Simons description of the quantum Hall effect and bosonization of collective fermion states are used as specific examples.Comment: To appear in "Seminaire Poincare X", Institut Henri Poincare, Paris; references adde

Epstein-Barr virus: clinical and epidemiological revisits and genetic basis of oncogenesis

Epstein-Barr virus (EBV) is classified as a member in the order herpesvirales, family herpesviridae, subfamily gammaherpesvirinae and the genus lymphocytovirus. The virus is an exclusively human pathogen and thus also termed as human herpesvirus 4 (HHV4). It was the first oncogenic virus recognized and has been incriminated in the causation of tumors of both lymphatic and epithelial nature. It was reported in some previous studies that 95% of the population worldwide are serologically positive to the virus. Clinically, EBV primary infection is almost silent, persisting as a life-long asymptomatic latent infection in B cells although it may be responsible for a transient clinical syndrome called infectious mononucleosis. Following reactivation of the virus from latency due to immunocompromised status, EBV was found to be associated with several tumors. EBV linked to oncogenesis as detected in lymphoid tumors such as Burkitt's lymphoma (BL), Hodgkin's disease (HD), post-transplant lymphoproliferative disorders (PTLD) and T-cell lymphomas (e.g. Peripheral T-cell lymphomas; PTCL and Anaplastic large cell lymphomas; ALCL). It is also linked to epithelial tumors such as nasopharyngeal carcinoma (NPC), gastric carcinomas and oral hairy leukoplakia (OHL). In vitro, EBV many studies have demonstrated its ability to transform B cells into lymphoblastoid cell lines (LCLs). Despite these malignancies showing different clinical and epidemiological patterns when studied, genetic studies have suggested that these EBV- associated transformations were characterized generally by low level of virus gene expression with only the latent virus proteins (LVPs) upregulated in both tumors and LCLs. In this review, we summarize some clinical and epidemiological features of EBV- associated tumors. We also discuss how EBV latent genes may lead to oncogenesis in the different clinical malignancie

Suxamethonium riskant op de intensive care

Contains fulltext : 23065___.PDF (publisher's version ) (Open Access

Prediction admission in the older population in the Emergency Department: the CLEARED tool

Background: Length of stay (LOS) in the Emergency Department (ED) is correlated with an extended in-hospital LOS and may even increase 30-day mortality. Older patients represent a growing population in the ED and they are especially at risk of adverse outcomes. Screening tools that adequately predict admission could help reduce waiting times in the ED and reduce time to treatment. We aimed to develop and validate a clinical prediction tool for admission, applicable to the aged patient population in the ED.Methods: Data from 7,606 ED visits of patients aged 70 years and older between 2012 and 2014 were used to develop the CLEARED tool. Model performance was assessed with discrimination using logistic regression and calibration. The model was internally validated by bootstrap resampling in Erasmus Medical Center and externally validated at two other hospitals, Medisch Spectrum Twente (MST) and Leiden University Medical Centre (LUMC).Results: CLEARED contains 10 predictors: body temperature, heart rate, diastolic blood pressure, systolic blood pressure, oxygen saturation, respiratory rate, referral status, the Manchester Triage System category, and the need for laboratory or radiology testing. The internally validated area under the curve (AUC) was 0.766 (95% CI [0759; 0.780. External validation in MST showed an AUC of o.797 and in LUMC, an AUC of 0.725.Conclusions: The developed CLEARED tool reliably predicts admission in elderly patients visiting the ED. It is a promising prompt, although further research is needed to implement the tool and to investigate the benefits in terms of reduction of crowding and LOS in the ED.Public Health and primary careGeriatrics in primary car