Effect of blade row interaction on rotor film cooling

Abstract The mechanisms of blade row interaction affecting rotor film cooling are identified to make recommendations for the design of film cooling in the real, unsteady turbine environment. Present design practice makes the simplifying assumption of steady boundary conditions despite intrinsic unsteadiness due to blade row interaction; we argue that if film cooling responds nonlinearly to unsteadiness, the time-averaged performance will then be in error. Nonlinear behavior is confirmed using experimental measurements of flat-plate cylindrical film cooling holes, mainstream unsteadiness causing a reduction in film effectiveness of up to 31% at constant time-averaged boundary condition. Unsteady computations are used to identify the blade row interaction mechanisms in a high-pressure turbine rotor: a “negative jet” associated with the upstream vane wake, and frozen and propagating vane potential field interactions. A quasi-steady model is used to predict unsteady excursions in momentum flux ratio of rotor cooling holes, with fluctuations of at least ±30% observed for all hole locations. Computations with modified upstream vanes are used to vary the relative strength of wake and potential field interactions. In general, both mechanisms contribute to rotor film cooling unsteadiness. It is recommended that the designer should choose a cooling configuration that behaves linearly over the expected unsteady excursions in momentum flux ratio as predicted by a quasi-steady hole model.Mitsubishi Heavy Industrie

Scattering by Surface-Breaking and Sub-Surface Cracks

This paper is concerned with exact solutions and approximate solutions in the high-frequency domain for scattering of time-harmonic waves by surface-breaking cracks and cracks which are located near a free surface. Both incident surface waves and incident body waves have been considered. The high-frequency approximate solutions are generally based on elastodynamic ray theory. Some approximate solutions based on the Kirchhoff approximation have been included for comparison

Loss in axial compressor bleed systems

Abstract Loss in axial compressor bleed systems is quantified and the loss mechanisms are identified to determine how efficiency can be improved. For a given bleed air pressure requirement, reducing bleed system loss allows air to be bled from further upstream in the compressor, with benefits for the thermodynamic cycle. A definition of isentropic efficiency, which includes bleed flow is used to account for this. Two cases with similar bleed systems are studied: a low-speed, single-stage research compressor, and a large industrial gas turbine high-pressure compressor. A new method for characterizing bleed system loss is introduced, using research compressor test results as a demonstration case. A loss coefficient is defined for a control volume including only flow passing through the bleed system. The coefficient takes a measured value of 95% bleed system inlet dynamic head and is shown to be a weak function of compressor operating point and bleed rate, varying by ±2.2% over all tested conditions. This loss coefficient is the correct nondimensional metric for quantifying and comparing bleed system performance. Computations of the research compressor and industrial gas turbine compressor identify the loss mechanisms in the bleed system flow. In both cases, approximately two-thirds of total loss is due to shearing of a high-velocity jet at the rear face of the bleed slot, one-quarter is due to mixing in the plenum chamber, and the remainder occurs in the off-take duct. Therefore, the main objective of a designer should be to diffuse the flow within the bleed slot. A redesigned bleed slot geometry is presented that achieves this objective and reduces the loss coefficient by 31%.Mitsubishi Heavy Industrie

Prevalence of hepatitis C virus infection in patients with lymphoproliferative disorders in Southern Turkey

PubMedID: 10424729Anti-hepatitis C virus (HCV) antibody prevalence was investigated in 228 patients with lymphoproliferative disorders (LPDs). Twenty-six of 228 (11.40%) patients with LPDs were positive for anti-HCV which was higher than the donor population (P = 0.0007). Nine of 98 cases with non-Hodgkin's lymphoma, five of 47 cases with multiple myeloma, seven of 36 cases with Hodgkin's disease, four of 38 cases with chronic lymphocytic leukaemia and one of nine cases with acute lymphoblastic leukaemia had anti-HCV antibody. In all patients, odds ratio (OR) for anti-HCV was 24.09. This value was higher in patients less than 35 years as 62.04 for below 25 years and 32.00 for between 25-35 years. Our findings suggest that HCV infection might be a causative and/or contributing factor in lymphoproliferation

Towards mentoring as feminist praxis in early childhood education and care in England

Following our contribution to a study of mentoring in seven European countries, we explored epistemological and ontological inconsistencies within mainstream mentoring systems and their regulated practice in England. We considered how feminist mentoring praxis can unsettle conceptualisations of mentoring relationships and challenge inequity in the early education systems and the practice of teaching young children. Predominantly female, early childhood educators suffer from low status in England, and their working lives may be controlled and policed through inequitable systems. On entering the workforce, trainees encounter a reductionist policy milieu where mentoring structures and normative assessment arrangements contribute to inequity. Mentors play pivotal roles in inducting trainees into their worlds of work with young children. Mentoring relationships can determine whether trainees accept the status quo. Principles derived from feminist praxis enable mentors to practise an ‘engaged pedagogy’, co-constructing knowledge, subverting hierarchies and contesting taken-for-granted aspects of policy and practice

Body mass index and circulating oestrone sulphate in women treated with adjuvant letrozole

Background: Obesity is an independent adverse prognostic factor in early breast cancer patients, but it is still controversial whether obesity may affect adjuvant endocrine therapy efficacy. The aim of our study (ancillary to the two clinical trials Gruppo Italiano Mammella (GIM)4 and GIM5) was to investigate whether the circulating oestrogen levels during treatment with the aromatase inhibitor letrozole are related to body mass index (BMI) in postmenopausal women with breast cancer. Methods: Plasma concentration of oestrone sulphate (ES) was evaluated by radioimmunoassay in 370 patients. Plasma samples were obtained after at least 6 weeks of letrozole therapy (steady-state time). Patients were divided into four groups according to BMI. Differences among the geometric means (by ANOVA and ANCOVA) and correlation (by Spearman's rho) between the ES levels and BMI were assessed. Results: Picomolar geometric mean values (95% confidence interval, n=patients) of circulating ES during letrozole were 58.6 (51.0-67.2, n=150) when BMI was <25.0 kg m-2; 65.6 (57.8-74.6, n=154) when 25.0-29.9 kg m-2; 59.3 (47.1-74.6, n=50) when 30.0-34.9 kg m -2; and 43.3 (23.0-81.7, n=16) when 6535.0 kg m-2. No statistically significant difference in terms of ES levels among groups and no correlation with BMI were observed. Conclusions: Body mass index does not seem to affect circulating oestrogen levels in letrozole-treated patient

β-catenin is a molecular switch that regulates transition of cell-cell adhesion to fusion

When a sperm and an oocyte unite upon fertilization, their cell membranes adhere and fuse, but little is known about the factors regulating sperm-oocyte adhesion. Here we explored the role of β-catenin in sperm-oocyte adhesion. Biochemical analysis revealed that E-cadherin and β-catenin formed a complex in oocytes and also in sperm. Sperm-oocyte adhesion was impaired when β-catenin-deficient oocytes were inseminated with sperm. Furthermore, expression of β-catenin decreased from the sperm head and the site of an oocyte to which a sperm adheres after completion of sperm-oocyte adhesion. UBE1-41, an inhibitor of ubiquitin-activating enzyme 1, inhibited the degradation of β-catenin, and reduced the fusing ability of wild-type (but not β-catenin-deficient) oocytes. These results indicate that β-catenin is not only involved in membrane adhesion, but also in the transition to membrane fusion upon fertilization

Primary biliary cirrhosis

Primary biliary cirrhosis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology characterized by injury of the intrahepatic bile ducts that may eventually lead to liver failure. Affected individuals are usually in their fifth to seventh decades of life at time of diagnosis, and 90% are women. Annual incidence is estimated between 0.7 and 49 cases per million-population and prevalence between 6.7 and 940 cases per million-population (depending on age and sex). The majority of patients are asymptomatic at diagnosis, however, some patients present with symptoms of fatigue and/or pruritus. Patients may even present with ascites, hepatic encephalopathy and/or esophageal variceal hemorrhage. PBC is associated with other autoimmune diseases such as Sjogren's syndrome, scleroderma, Raynaud's phenomenon and CREST syndrome and is regarded as an organ specific autoimmune disease. Genetic susceptibility as a predisposing factor for PBC has been suggested. Environmental factors may have potential causative role (infection, chemicals, smoking). Diagnosis is based on a combination of clinical features, abnormal liver biochemical pattern in a cholestatic picture persisting for more than six months and presence of detectable antimitochondrial antibodies (AMA) in serum. All AMA negative patients with cholestatic liver disease should be carefully evaluated with cholangiography and liver biopsy. Ursodeoxycholic acid (UDCA) is the only currently known medication that can slow the disease progression. Patients, particularly those who start UDCA treatment at early-stage disease and who respond in terms of improvement of the liver biochemistry, have a good prognosis. Liver transplantation is usually an option for patients with liver failure and the outcome is 70% survival at 7 years. Recently, animal models have been discovered that may provide a new insight into the pathogenesis of this disease and facilitate appreciation for novel treatment in PBC