Chronic Atopic Dermatitis: Symptom Management Using Moisturizers Among Asian American Pediatrics

Background: Atopic Dermatitis (AD), also commonly known as eczema, affects 31.6 million (10%) of the United States Population, with 13% being Asian American or Pacific Islander. A cure is not present for AD; however, the best way to treat AD is with symptom management. While there are many pharmacological treatments that aid with symptom management such as topical or oral corticosteroids, there are also non pharmacological treatments such as moisturizers that can aid with symptom relief of AD as well. Objective: The literature review explores moisturizer use and other non pharmacological methods for symptom management of AD and provides understanding of topical corticosteroids perceptions among the public. This research proposal will investigate whether or not moisturizers provide symptom relief among Asian American pediatric children that have atopic dermatitis. Method: A quantitative, quasi-experimental study over an 8 week period will be used with a sample size of 150 participants. Once the 150 participants are selected, they will be randomly placed in either the control or experimental group. The moisturizer that will be used is Cetaphil Restoraderm Moisturizer (CRM). Both groups will receive education on non pharmacological methods to help manage AD; however, the control group will not receive the moisturizer intervention. The severity of atopic dermatitis will be measured by SCORAD, VAS itch scores, TEWL, and a questionnaire that asks about quality of life before and after the intervention. As a result of the study, there is an expectation that SCORAD, VAS, and TEWL scores will decrease

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Chronic Atopic Dermatitis: Symptom Management Using Moisturizers Among Asian American Pediatrics

Background: Atopic Dermatitis (AD), also commonly known as eczema, affects 31.6 million (10%) of the United States Population, with 13% being Asian American or Pacific Islander. A cure is not present for AD; however, the best way to treat AD is with symptom management. While there are many pharmacological treatments that aid with symptom management such as topical or oral corticosteroids, there are also non pharmacological treatments such as moisturizers that can aid with symptom relief of AD as well. Objective: The literature review explores moisturizer use and other non pharmacological methods for symptom management of AD and provides understanding of topical corticosteroids perceptions among the public. This research proposal will investigate whether or not moisturizers provide symptom relief among Asian American pediatric children that have atopic dermatitis. Method: A quantitative, quasi-experimental study over an 8 week period will be used with a sample size of 150 participants. Once the 150 participants are selected, they will be randomly placed in either the control or experimental group. The moisturizer that will be used is Cetaphil Restoraderm Moisturizer (CRM). Both groups will receive education on non pharmacological methods to help manage AD; however, the control group will not receive the moisturizer intervention. The severity of atopic dermatitis will be measured by SCORAD, VAS itch scores, TEWL, and a questionnaire that asks about quality of life before and after the intervention. As a result of the study, there is an expectation that SCORAD, VAS, and TEWL scores will decrease.https://scholar.dominican.edu/nursing-student-research-posters/1051/thumbnail.jp

Restoring Trust and Building Integrity in Government: Issues and Concerns in the Philippines and Areas for Reform

In most general terms this article addresses the issue of the continuing decline of trust in government and the imperatives for reform. The decline on trust in government has been brought about by many factors including the inefficient and ineffective delivery of services, waste of public resources, graft and corruption, lack of integrity in government, poor leadership, excessive red tape, ineffective reorganization and structural changes, too much centralization, among other things. In summary, unresponsive governance has been responsible for the continuing decline of trust in government. The article introduces a framework of areas of reform imperatives with the general objective of restoring trust in government. These areas include the following: (1) reforms in institutions and structures, including reforms in organizations, processes and procedures; (2) reforms in mindsets, paradigms and behavior; (3) reforms in leadership at various levels; and (4) reforms among citizens, i.e., citizen engagement and/or citizen participation. We begin by reviewing various examples in the Philippines including continuing efforts to address graft and corruption, red tape, and inefficiencies in the government’s politico-administrative environment

LGU Access to Official Development Assistance (ODA): Status, Issues, and Concerns

Statistics on the distribution of ODA loans show that the local government sector is the smallest direct recipient of this funding source. While it has been observed that the amount of ODA grants and the number of ODA grant projects have been declining over the years, several factors could explain why LGUs have not been able to have a substantial share in ODA funds. The study discusses barriers to the greater of LGUs to ODA funds and provides specific recommendations for action by policymakers

Public policy (not the coronavirus) should shape what endemic means

Endemicity is not only a biological and health event but has several inter-dependencies cross-cutting with the management of the economy, including governance and policies. Within the context of the discourse on inequity, what does endemicity mean for poor and low-income families, where policies on social inclusion and social welfare need to be re-calibrated

Interactome mapping reveals the evolutionary history of the nuclear pore complex

The nuclear pore complex (NPC) is responsible for nucleocytoplasmic transport and constitutes a hub for control of gene expression. The components of NPCs from several eukaryotic lineages have been determined, but only the yeast and vertebrate NPCs have been extensively characterized at the quaternary level. Significantly, recent evidence indicates that compositional similarity does not necessarily correspond to homologous architecture between NPCs from different taxa. To address this, we describe the interactome of the trypanosome NPC, a representative, highly divergent eukaryote. We identify numerous new NPC components and report an exhaustive interactome, allowing assignment of trypanosome nucleoporins to discrete NPC substructures. Remarkably, despite retaining similar protein composition, there are exceptional architectural dissimilarities between opisthokont (yeast and vertebrates) and excavate (trypanosomes) NPCs. Whilst elements of the inner core are conserved, numerous peripheral structures are highly divergent, perhaps reflecting requirements to interface with divergent nuclear and cytoplasmic functions. Moreover, the trypanosome NPC has almost complete nucleocytoplasmic symmetry, in contrast to the opisthokont NPC; this may reflect divergence in RNA export processes at the NPC cytoplasmic face, as we find evidence supporting Ran-dependent mRNA export in trypanosomes, similar to protein transport. We propose a model of stepwise acquisition of nucleocytoplasmic mechanistic complexity and demonstrate that detailed dissection of macromolecular complexes provides fuller understanding of evolutionary processes

Evaluation Of Three Candidate DNA Barcoding Loci In Selected Ficus L. (Moraceae)

Abstract: The genus Ficus L. (Moraceae) is known for its diverse morphology and habit as well as economical, ecological, and pharmaceutical importance. In this study, six Philippine Ficus species were utilized to determine the best barcoding loci among cpDNA (rbcL, trnH-psbA) and nrDNA (ITS) markers on the basis of universality, discriminatory power, and resolution of species. Both trnH-psbA and ITS showed 100% PCR success rate and 67% sequencing success, whereas rbcL exhibited 67% PCR success rate but 100% sequencing success. The trnH-psbA marker performed best in terms of discriminatory power, showing the highest variable informative site (71.37%) and the highest mean interspecific distance (48.32% ± 19.89%). ITS ranked next to trnH-psbA since it was able to generate 100% resolution of species and a comparable mean intraspecific distance score with trnHpsbA. Meanwhile, rbcL failed to resolve any species correctly; thus, it has a 0% resolution of species. We initially recommend trnH-psbA and ITS as potential DNA barcodes for molecular authentication of Ficus species

Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux

AbstractThe immunosuppressant drug FK506 binds to the immunophilin protein FKBP12 and inhibits its prolyl isomerase activity. Immunosuppresive actions, however, are mediated via an FK506-FKBP12 inhibition of the Ca2+-activated phosphatase calcineurin. Physiologic cellular roles for FKBP12 have remained unclear. FKBP12 is physically associated with the RyR and IP3R Ca2+ channels in the absence of FK506, with added FK506 disrupting these complexes. Dissociation of FKBP12 results in alteration of channel Ca2+ conductance in both cases. We now report that calcineurin is physiologically associated with the IP3R-FKBP12 and RyR-FKBP12 receptor complexes and that this interaction can be disrupted by FK506 or rapamycin. Calcineurin anchored to the IP3R via FKBP12 regulates the phosphorylation status of the receptor, resulting in a dynamic Ca2+-sensitive regulation of IP3-mediated Ca2+ flux