A note on the estimation of confidence intervals for cost-effectiveness when costs and effects are censored

<i>Background</i>. The relation between methodological advances in estimation of confidence intervals (CIs) for incremental cost-effectiveness ratios (ICER) and estimation of cost effectiveness in the presence of censoring has not been explored. The authors address the joint problem of estimating ICER precision in the presence of censoring. <i>Methods</i>. Using patient-level data (n = 168) on cost and survival from a published placebo-controlled trial, the authors compared 2 methods of measuring uncertainty with censored data: 1)Bootstrap with censor adjustment (BCA); 2) Fieller’s method with censor adjustment (FCA). The authors estimate the FCA over all possible values for the correlation (p) between costs and effects (range= –1 to +1) and also examine the use of the correlation between cases without censoring adjustment (i.e., simple time-on-study) for costs and effects as an approximation for. <i>Results</i>. Using time-on-study, which considers all censored observations as responders (deaths), yields 0.64 life-years gained at an additional cost of 87.9 for a cost per life-year of 137 (95% CI by bootstrap –5.9 to 392). Censoring adjustment corrects for the bias in the time-on-study approach and reduces the cost per life-year estimate to 132 (=72/0.54). Confidence intervals with censor adjustment were approximately 40% wider than the base-case without adjustment. Using the Fieller method with an approximation of based on the uncensored cost and effect correlation provides a 95% CI of (–48 to 529), which is very close to the BCA interval of (–52 to 504). <i>Conclusions</i>. Adjustment for censoring is necessary in cost-effectiveness studies to obtain unbiased estimates of ICER with appropriate uncertainty limits. In this study, BCA and FCA methods, the latter with approximated covariance, are simple to compute and give similar confidence intervals

Spin detection at elevated temperatures using a driven double quantum dot

We consider a double quantum dot in the Pauli blockade regime interacting with a nearby single spin. We show that under microwave irradiation the average electron occupations of the dots exhibit resonances that are sensitive to the state of the nearby spin. The system thus acts as a spin meter for the nearby spin. We investigate the conditions for a non-demolition read-out of the spin and find that the meter works at temperatures comparable to the dot charging energy and sensitivity is mainly limited by the intradot spin relaxation.Comment: 8 pages, 6 figure

Electrically driven spin resonance in a bent disordered carbon nanotube

Resonant manipulation of carbon nanotube valley-spin qubits by an electric field is investigated theoretically. We develop a new analysis of electrically driven spin resonance exploiting fixed physical characteristics of the nanotube: a bend and inhomogeneous disorder. The spectrum is simulated for an electron valley-spin qubit coupled to a hole valley-spin qubit and an impurity electron spin, and features that coincide with a recent measurement are identified. We show that the same mechanism allows resonant control of the full four-dimensional spin-valley space.Comment: 11 pages, 7 figure

3D-2D crossover in the naturally layered superconductor (LaSe)1.14(NbSe2)

The temperature and angular dependencies of the resistive upper critical magnetic field $B_{c2}$ reveal a dimensional crossover of the superconducting state in the highly anisotropic misfit-layer single crystal of (LaSe)$_{1.14}$(NbSe$_2$) with the critical temperature $T_c$ of 1.23 K. The temperature dependence of the upper critical field $B_{c2\parallel ab}(T)$ for a field orientation along the conducting $(ab)$-planes displays a characteristic upturn at 1.1 K and below this temperature the angular dependence of $B_{c2}$ has a cusp around the parallel field orientation. Both these typical features are observed for the first time in a naturally crystalline layered system.Comment: 7 pages incl. 3 figure

Relationships between lipophilicity and root uptake and translocation of non-ionized chemicals by barley

The uptake by roots from solution, and subsequent translocation to shoots in barley, of two series of non‐ionised chemicals, O‐methylcarbamoyloximes and substituted phenylureas, were measured, Uptake of the chemicals by roots was greater the more lipophilic the chemical, and fell to a lower limiting value for polar chemicals. Translocation to the shoots was a passive process, and was most efficient for compounds of intermediate polarity. Both processes had reached equilibrium within 24h of treatment. The reported behaviour of many pesticides in various plant species agrees with the derived relationships, but the detailed mechanisms of these processes are unknown.&nbsp

Time Dependent Clustering Analysis of the Second BATSE Gamma-Ray Burst Catalog

A time dependent two-point correlation-function analysis of the BATSE 2B catalog finds no evidence of burst repetition. As part of this analysis, we discuss the effects of sky exposure on the observability of burst repetition and present the equation describing the signature of burst repetition in the data. For a model of all burst repetition from a source occurring in less than five days we derive upper limits on the number of bursts in the catalog from repeaters and model-dependent upper limits on the fraction of burst sources that produce multiple outbursts.Comment: To appear in the Astrophysical Journal Letters, uuencoded compressed PostScript, 11 pages with 4 embedded figure