HOG PRODUCER INVESTMENT IN VALUE-ADDED AGRIBUSINESS: RISK AND RETURN IMPLICATIONS

Although producers have been enticed into investment in value-added agribusiness the risk and return impacts have not been quantified. A spreadsheet simulation model is used to evaluate how investments by hog farmers in slaughter plants and other alternatives affect returns and risk. Results suggest that hog producer investment in value-added agribusiness is efficient.Value-Added, Producer Investment, Financial Economics, Livestock Production/Industries,

Models Of Tensile Behavior OF Meta-Stable Fe-Mn-Mo Alloys

A semi-mechanistic model for predicting the flow behaviour of Fe-Mn-Mo steels displaying transformation-induced plasticity is developed in this paper. The model, based on the law of mixtures, takes into account the work-hardening of the individual principal phases (namely, lath-martensite and austenite/epsilon martensit~). The composite strength of such a steel may be given by a modified law of mixtures which incorporates a dislocation density effect. To test the validity of the model, experiments have been performed using a magnetic reluctance technique to determine the extent of 'f + F.: 7 a.' transformaU.on induced by tensile plastic deformation at room temperature. As the 'f + e: 7 a.' transformation progressed the work-hardening of the steels was found to increase rapidly. It is concluded that the ind~ced lath-martensite in a work-hardened austenite/epsilon mat~ix is most effective in enhancing strength and ductilit

Restrictive antibiotic stewardship associated with reduced hospital mortality in gram-negative infection

Introduction: Antimicrobial stewardship has an important role in the control of Clostridium difficile infection (CDI) and antibiotic resistance. An important component of UK stewardship interventions is the restriction of broad-spectrum beta-lactam antibiotics and promotion of agents associated with a lower risk of CDI such as gentamicin. Whilst the introduction of restrictive antibiotic guidance has been associated with improvements in CDI and antimicrobial resistance evidence of the effect on outcome following severe infection is lacking. Methods: In 2008, Glasgow hospitals introduced a restrictive antibiotic guideline. A retrospective before/after study assessed outcome following gram-negative bacteraemia in the 2-year period around implementation. Results: Introduction of restrictive antibiotic guidelines was associated with a reduction in utilisation of ceftriaxone and co-amoxiclav and an increase in amoxicillin and gentamicin. 1593 episodes of bacteraemia were included in the study. The mortality over 1 year following gram-negative bacteraemia was lower in the period following guideline implementation (RR 0.852, P = 0.045). There was no evidence of a difference in secondary outcomes including ITU admission, length of stay, readmission, recurrence of bacteraemia and need for renal replacement therapy. There was a fall in CDI (RR 0.571, P = 0.014) and a reduction in bacterial resistance to ceftriaxone and co-amoxiclav but no evidence of an increase in gentamicin resistance after guideline implementation. Conclusion: Restrictive antibiotic guidelines were associated with a reduction in CDI and bacterial resistance but no evidence of adverse outcomes following gram-negative bacteraemia. There was a small reduction in one year mortality

Deformation Characteristics and Work-hardening Behaviour of some High Strength Manganese Steels

A study has been made on a new type of wear resistant/high strength iron-manganse-molybdenum steel. This study includes the influence of composition and heat treatment on the mechanical properties. The exceptional work-hardening rate is due to strain-induced formation of lath martensite which itself also takes part in the work-hardening process. The influence of higher molybdenum contents was evident in preventing brittleness of the solution treated steels. An optimum composition range for this type of steel is indicated

The Skills Framework for the Information Age: Engaging Stakeholders in Curriculum Design

This paper reports on a research project, examining the role of the Skills Framework for the Information Age (SFIA) in Information and Communications Technology (ICT) curriculum design and management. A goal was to investigate how SFIA informs a top-down approach to curriculum design, beginning with a set of skills that define a particular career role. A further goal was to evaluate the extent to which SFIA facilitates stakeholder interaction, such that academic programs can better identify industry needs while preparing graduates for the intended career role. The paper also evaluates the extent to which SFIA informs the identification of authentic forms of assessment and the skills and levels of autonomy and responsibility required by entry-level and Masters graduate ICT positions. Processes and practices for ICT curriculum design and management are recommended based on findings arising from this research. Although this research was conducted in an Australian context, findings suggest that there is value in using SFIA for ICT curriculum design and management, even in those jurisdictions where it is not required for accreditation or professional certification purposes

Comparative metagenomic analysis of plasmid encoded functions in the human gut microbiome

Background: Little is known regarding the pool of mobile genetic elements associated with the human gut microbiome. In this study we employed the culture independent TRACA system to isolate novel plasmids from the human gut microbiota, and a comparative metagenomic analysis to investigate the distribution and relative abundance of functions encoded by these plasmids in the human gut microbiome. Results: Novel plasmids were acquired from the human gut microbiome, and homologous nucleotide sequences with high identity (>90%) to two plasmids (pTRACA10 and pTRACA22) were identified in the multiple human gut microbiomes analysed here. However, no homologous nucleotide sequences to these plasmids were identified in the murine gut or environmental metagenomes. Functions encoded by the plasmids pTRACA10 and pTRACA22 were found to be more prevalent in the human gut microbiome when compared to microbial communities from other environments. Among the most prevalent functions identified was a putative RelBE toxin-antitoxin (TA) addiction module, and subsequent analysis revealed that this was most closely related to putative TA modules from gut associated bacteria belonging to the Firmicutes. A broad phylogenetic distribution of RelE toxin genes was observed in gut associated bacterial species (Firmicutes, Bacteroidetes, Actinobacteria and Proteobacteria), but no RelE homologues were identified in gut associated archaeal species. We also provide indirect evidence for the horizontal transfer of these genes between bacterial species belonging to disparate phylogenetic divisions, namely Gram negative Proteobacteria and Gram positive species from the Firmicutes division. Conclusions: The application of a culture independent system to capture novel plasmids from the human gut mobile metagenome, coupled with subsequent comparative metagenomic analysis, highlighted the unexpected prevalence of plasmid encoded functions in the gut microbial ecosystem. In particular the increased relative abundance and broad phylogenetic distribution was identified for a putative RelBE toxin/antitoxin addiction module, a putative phosphohydrolase/phosphoesterase, and an ORF of unknown function. Our analysis also indicates that some plasmids or plasmid families are present in the gut microbiomes of geographically isolated human hosts with a broad global distribution (America, Japan and Europe), and are potentially unique to the human gut microbiome. Further investigation of the plasmid population associated with the human gut is likely to provide important insights into the development, functioning and evolution of the human gut microbiota

Extreme morning chronotypes are often familial and not exceedingly rare: the estimated prevalence of advanced sleep phase, familial advanced sleep phase, and advanced sleep-wake phase disorder in a sleep clinic population.

Study objectivesReport the first prevalence estimates of advanced sleep phase (ASP), familial advanced sleep phase (FASP), and advanced sleep-wake phase disorder (ASWPD). This can guide clinicians on the utility of screening for extreme chronotypes both for clinical decision-making and to flag prospective participants in the study of the genetics and biology of FASP.MethodsData on morning or evening sleep schedule preference (chronotype) were collected from 2422 new patients presenting to a North American sleep center over 9.8 years. FASP was determined using a severity criterion that has previously identified dominant circadian mutations in humans. All patients were personally seen and evaluated by one of the authors (C.R.J.).ResultsOur results demonstrate an ASP prevalence of 0.33%, an FASP prevalence of 0.21%, and an ASWPD prevalence of at least 0.04%. Most cases of young-onset ASP were familial.ConclusionsAmong patients presenting to a sleep clinic, conservatively 1 out of every 300 patients will have ASP, 1 out of every 475 will have FASP, and 1 out of every 2500 will have ASWPD. This supports obtaining a routine circadian history and, for those with extreme chronotypes, obtaining a family history of circadian preference. This can optimize treatment for evening sleepiness and early morning awakening and lead to additional circadian gene discovery. We hope these findings will lead to improved treatment options for a wide range of sleep and medical disorders in the future

A 15-Kiloparsec X-Ray Disk in the Elliptical Galaxy NGC 1700

We present Chandra observations of the young elliptical galaxy NGC 1700. The X-ray isophotes are highly flattened between semimajor axes of 30 and 80 arcseconds, reaching a maximum ellipticity of approximately 0.65 at 60 arcsec (15 kpc). The surface brightness profile in the spectrally soft, flattened region is shallower than that of the starlight, indicating that the emission comes from hot gas rather than stellar sources. The flattening is so extreme that the gas cannot be in hydrostatic equilibrium in any plausible potential. A likely alternative is that the gas has significant rotational support. A simple model, representing isothermal gas distributed about a particular angular momentum, can reproduce the X-ray morphology while staying consistent with stellar kinematics. The specific angular momentum of the gas matches that of the stars in the most isophotally distorted outer part of the galaxy, and its cooling time matches the time since the last major merger. We infer that the gas was acquired in that merger, which involved a pre-existing elliptical galaxy with a hot ISM. The hot gas carried the angular momentum of the encounter, and has since gradually settled into a rotationally flattened, cooling disk.Comment: 11 pages, 2 figures, AASTeX 5.0. Accepted for publication in The Astrophysical Journa