Unitary Limit of Two-Nucleon Interactions in Strong Magnetic Fields

Two-nucleon systems are shown to exhibit large scattering lengths in strong magnetic fields at unphysical quark masses, and the trends toward the physical values indicate that such features may exist in nature. Lattice QCD calculations of the energies of one and two nucleons systems are performed at pion masses of $m_\pi\sim 450$ and 806 MeV in uniform, time-independent magnetic fields of strength {\bf B}| \sim 10^{19}$-$10^{20}$ Gauss to determine the response of these hadronic systems to large magnetic fields. Fields of this strength may exist inside magnetars and in peripheral relativistic heavy ion collisions, and the unitary behavior at large scattering lengths may have important consequences for these systems.Comment: Accepted journal versio

Ab initio calculation of the np→dγnp \to d \gamma radiative capture process

Lattice QCD calculations of two-nucleon systems are used to isolate the short-distance two-body electromagnetic contributions to the radiative capture process $np \to d\gamma$, and the photo-disintegration processes $\gamma^{(\ast)} d \to np$. In nuclear potential models, such contributions are described by phenomenological meson-exchange currents, while in the present work, they are determined directly from the quark and gluon interactions of QCD. Calculations of neutron-proton energy levels in multiple background magnetic fields are performed at two values of the quark masses, corresponding to pion masses of $m_\pi \sim 450$ and 806 MeV, and are combined with pionless nuclear effective field theory to determine these low-energy inelastic processes. Extrapolating to the physical pion mass, a cross section of $\sigma^{lqcd}(np\to d\gamma)=332.4({\tiny \begin{array}{l}+5.4 \\ - 4.7\end{array}})\ mb$ is obtained at an incident neutron speed of $v=2,200\ m/s$, consistent with the experimental value of$\sigma^{expt}(np \to d\gamma) = 334.2(0.5)\ mb$

A Systematic Review of Dental Disease in Patients Undergoing Cancer Therapy

Introduction: The purpose of this systematic review was to evaluate the literature and update our current understanding of the impact of present cancer therapies on the dental apparatus (teeth and periodontium) since the 1989 NIH Development Consensus Conference on the Oral Compli­cations of Cancer Therapies. Review Method: A systematic literature search was con­ducted with assistance from a research librarian in the databases MEDLINE/PubMed and EMBASE for articles published between 1 January 1990 and 31 December 2008. Each study was independently assessed by two reviewers. Taking into account predetermined quality measures, a weighted prevalence was calculated for the prevalence of dental caries, severe gingival disease, and dental infection. Data on DMFT/dmft, DMFS/dmfs, plaque, and gingival indexes were also gathered. The level of evidence, recommendation, and guideline (if possible) were given for published preventive and management strategies. Results: Sixty-four published papers between 1990 and 2008 were reviewed. The weighted overall prevalence of dental caries was 28.1%. The overall DMFT for patients who were post-antineoplastic therapy was 9.19 (SD, 7.98; n=457). The overall plaque index for patients who were post­antineoplastic therapy was 1.38 (SD, 0.25; n=189). The GI for patients who were post-chemotherapy was 1.02 (SD, 0.15; n=162). The weighted prevalence of dental infections/ abscess during chemotherapy was reported in three studies and was 5.8%. Conclusions: Patients who were post-radiotherapy had the highest DMFT. The use of fluoride products and chlorhex­idine rinses are beneficial in patients who are post-radiotherapy. There continues to be lack of clinical studies on the extent and severity of dental disease that are associated with infectious complications during cancer therapy

The Magnetic Structure of Light Nuclei from Lattice QCD

Lattice QCD with background magnetic fields is used to calculate the magnetic moments and magnetic polarizabilities of the nucleons and of light nuclei with $A\le4$, along with the cross-section for the $M1$ transition $np\rightarrow d\gamma$, at the flavor SU(3)-symmetric point where the pion mass is $m_\pi\sim 806$ MeV. These magnetic properties are extracted from nucleon and nuclear energies in six uniform magnetic fields of varying strengths. The magnetic moments are presented in a recent Letter. For the charged states, the extraction of the polarizability requires careful treatment of Landau levels, which enter non-trivially in the method that is employed. The nucleon polarizabilities are found to be of similar magnitude to their physical values, with $\beta_p=5.22(+0.66/-0.45)(0.23) \times 10^{-4}$ fm$^3$ and $\beta_n=1.253(+0.056/-0.067)(0.055) \times 10^{-4}$ fm$^3$, exhibiting a significant isovector component. The dineutron is bound at these heavy quark masses and its magnetic polarizability, $\beta_{nn}=1.872(+0.121/-0.113)(0.082) \times 10^{-4}$ fm$^3$ differs significantly from twice that of the neutron. A linear combination of deuteron scalar and tensor polarizabilities is determined by the energies of the $j_z=\pm 1$ deuteron states, and is found to be $\beta_{d,\pm 1}=4.4(+1.6/-1.5)(0.2) \times 10^{-4}$ fm$^3$. The magnetic polarizabilities of the three-nucleon and four-nucleon systems are found to be positive and similar in size to those of the proton, $\beta_{^{3}\rm He}=5.4(+2.2/-2.1)(0.2) \times 10^{-4}$ fm$^3$, $\beta_{^{3}\rm H}=2.6(1.7)(0.1) \times 10^{-4}$ fm$^3$, $\beta_{^{4}\rm He}=3.4(+2.0/-1.9)(0.2) \times 10^{-4}$ fm$^3$. Mixing between the $j_z=0$ deuteron state and the spin-singlet $np$ state induced by the background magnetic field is used to extract the short-distance two-nucleon counterterm, ${\bar L}_1$, of the pionless effective theory for $NN$ systems (equivalent to the meson-exchange current contribution in nuclear potential models), that dictates the cross-section for the $np\to d\gamma$ process near threshold. Combined with previous determinations of NN scattering parameters, this enables an ab initio determination of the threshold cross-section at these unphysical masses.Comment: 49 pages, 24 figure

Assessment of severe malaria in a multicenter, phase III, RTS, S/AS01 malaria candidate vaccine trial: case definition, standardization of data collection and patient care.

BACKGROUND\ud \ud An effective malaria vaccine, deployed in conjunction with other malaria interventions, is likely to substantially reduce the malaria burden. Efficacy against severe malaria will be a key driver for decisions on implementation. An initial study of an RTS, S vaccine candidate showed promising efficacy against severe malaria in children in Mozambique. Further evidence of its protective efficacy will be gained in a pivotal, multi-centre, phase III study. This paper describes the case definitions of severe malaria used in this study and the programme for standardized assessment of severe malaria according to the case definition.\ud \ud METHODS\ud \ud Case definitions of severe malaria were developed from a literature review and a consensus meeting of expert consultants and the RTS, S Clinical Trial Partnership Committee, in collaboration with the World Health Organization and the Malaria Clinical Trials Alliance. The same groups, with input from an Independent Data Monitoring Committee, developed and implemented a programme for standardized data collection.The case definitions developed reflect the typical presentations of severe malaria in African hospitals. Markers of disease severity were chosen on the basis of their association with poor outcome, occurrence in a significant proportion of cases and on an ability to standardize their measurement across research centres. For the primary case definition, one or more clinical and/or laboratory markers of disease severity have to be present, four major co-morbidities (pneumonia, meningitis, bacteraemia or gastroenteritis with severe dehydration) are excluded, and a Plasmodium falciparum parasite density threshold is introduced, in order to maximize the specificity of the case definition. Secondary case definitions allow inclusion of co-morbidities and/or allow for the presence of parasitaemia at any density. The programmatic implementation of standardized case assessment included a clinical algorithm for evaluating seriously sick children, improvements to care delivery and a robust training and evaluation programme for clinicians.\ud \ud CONCLUSIONS\ud \ud The case definition developed for the pivotal phase III RTS, S vaccine study is consistent with WHO recommendations, is locally applicable and appropriately balances sensitivity and specificity in the diagnosis of severe malaria. Processes set up to standardize severe malaria data collection will allow robust assessment of the efficacy of the RTS, S vaccine against severe malaria, strengthen local capacity and benefit patient care for subjects in the trial.\ud \ud TRIAL REGISTRATION\ud \ud Clinicaltrials.gov NCT00866619

Primitive neuroectodermal adrenal gland tumour

Ewing's sarcoma, also called primitive neuroectodermal tumour of the adrenal gland, is extremely rare. Only a few cases have been reported in the literature. We report on a woman with adult-onset primitive neuroectodermal tumour of the adrenal gland presenting with progressive flank pain. Computed tomography confirmed an adrenal tumour with invasion of the left diaphragm and kidney. Radical surgery was performed and the pain completely resolved; histology confirmed the presence of primitive neuroectodermal tumour, for which she was given chemotherapy. The clinical presentation of this condition is non-specific, and a definitive diagnosis is based on a combination of histology, as well as immunohistochemical and cytogenic analysis. According to the literature, these tumours demonstrate rapid growth and aggressive behaviour but there are no well-established guidelines or treatment strategies. Nevertheless, surgery remains the mainstay of local disease control; curative surgery can be performed in most patients. Adjuvant chemoirradiation has been advocated yet no consensus is available. The prognosis of patients with primitive neuroectodermal tumours remains poor.published_or_final_versio

Silver-Russell syndrome in Hong Kong

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Systematic Review of Laser and Other Light Therapy for the Management of Oral Mucositis in Cancer Patients

Background The aim of this study was to review the available literature and define clinical practice guidelines for the use of laser and other light therapies for the prevention and treatment of oral mucositis. Methods A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology. The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. Based onthe evidence level, one of the following three guideline determinations was possible: recommendation, suggestion, and no guideline possible. Results A new recommendation was made for low-level laser (wavelength at 650 nm, power of 40 mW, and each square centimeter treated with the required time to a tissue energy dose of 2 J/cm2 (2 s/point)) for the prevention of oral mucositis in adult patients receiving hematopoietic stem cell transplantation conditioned with high-dose chemotherapy, with or without total body irradiation. A new suggestion was made for low-level laser (wavelength around 632.8 nm) for the prevention of oral mucositis in patients undergoing radiotherapy, without concomitant chemotherapy, for head and neck cancer. No guideline was possible in other populations and for other light sources due to insufficient evidence. Conclusions The increasing evidence in favor of low-level laser therapy allowed for the development of two new guidelines supporting this modality in the populations listed above. Evidence for other populations was also generally encouraging over a range of wavelengths and intensities. However, additional well-designed research is needed to evaluate the efficacy of laser and other light therapies in various cancer treatment settings

Clinical and genetic profile of catecholaminergic polymorphic ventricular tachycardia in Hong Kong Chinese children

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Pourquoi les politiques publiques sont-elles si peu suivies d’effets ?:Quelques interrogations

L’insertion des femmes sur le marché du travail a connu à la fois des avancées et des reculs. Si davantage de femmes accèdent à l’éducation supérieure et aux emplois qualifiés, d’autres sont touchées par la précarité et connaissent une dégradation de leurs conditions de travail et de vie. Face à ce constat ambivalent, on peut questionner la mise en œuvre et l’efficacité des politiques qui visent à promouvoir l’égalité entre les femmes et les hommes. Cet article a pour objectif de soulever quelques débats. Le plus souvent, les politiques publiques au sens large (y compris la protection sociale) sont définies en termes de compensation et de correction des inégalités et des discriminations. Mais elles ne concernent pas les causes effectives de l’extension du sous-emploi des femmes, qui relèvent du fonctionnement même du marché du travail. C’est donc la définition des politiques publiques qu’il faut interroger, en dépassant une vision binaire qui oppose d’une part un champ économique extérieur, d’autre part un champ social, juridique et culturel qui, seul, pourrait être l’objet d’inflexions. En réalité, le champ économique est aussi le produit des politiques publiques : la libre-concurrence et la prééminence du marché sont le résultat d’une action volontaire des États. Il faut donc réintégrer les politiques économiques dans le champ de la réflexion sur les moyens de combattre les discriminations à l’encontre des femmes.The integration of women into the labour market has gone through both upswings and downturns. In view of this ambivalent result, we can question the efficiency of public policies set up to overcome gender inequality and fight gender discrimination. Does a real will exist, and if so why is it so inefficient or so poorly implemented? What forms do individual and collective resistance take? Most of the time, public policies are defined in terms of compensation and correction. But they don’t deal with the actual causes of women’s underemployment resulting from labour market adjustments. It is therefore the definition of the public policies that we need to examine, going beyond a binary view that opposes economic issues, on the one hand, to social, juridical and cultural concerns on the other