The Grizzly, October 30, 1990

Ursinus Honored at Governor\u27s Mansion • Sam Stretton To Speak • Glassmoyer Retires • Heefner New Board President • The Gender of Speech: A Tri-Lambda Lecture • Career Day November 6th • Forbes to Speak to Clergy • Animal Lovers Unite • Mock DWI A Hit • Student Camp Experience • David is Great!! • Presenting Protheatre: The Changeling • Crutcher Leads Team• Muhlenberg Falls • Swimmers Open Season at Relay Meet • Women Running To MAC\u27s • Men Go for MAC Title • Soccer • Letters: Keep Ursinus Clean; Quad Keys Revoked?; Signs Stolen; Security, Please Hold • Environmentally Concerned? Get Active • Bush\u27s Environmental Lip Service • This Time for Real • Nature Versus Nurture: A Step in Solving the Puzzlehttps://digitalcommons.ursinus.edu/grizzlynews/1262/thumbnail.jp

A reference human induced pluripotent stem cell line for large-scale collaborative studies.

Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying development and disease, but the considerable phenotypic variation between lines makes it challenging to replicate key findings and integrate data across research groups. To address this issue, we sub-cloned candidate human iPSC lines and deeply characterized their genetic properties using whole genome sequencing, their genomic stability upon CRISPR-Cas9-based gene editing, and their phenotypic properties including differentiation to commonly used cell types. These studies identified KOLF2.1J as an all-around well-performing iPSC line. We then shared KOLF2.1J with groups around the world who tested its performance in head-to-head comparisons with their own preferred iPSC lines across a diverse range of differentiation protocols and functional assays. On the strength of these findings, we have made KOLF2.1J and its gene-edited derivative clones readily accessible to promote the standardization required for large-scale collaborative science in the stem cell field

Numerical Analysis of the Combined Influence of Accelerated Crucible Rotation and Dynamic Crucible Translation on Liquid Phase Diffusion Growth of SiGe

The effects of accelerated crucible rotation technique (ACRT) and dynamic translation on liquid phase diffusion (LPD) growth of SixGe1−x single crystals have been separately investigated numerically in earlier works and were found to have a very positive impact on the LPD growth process. Building upon these findings, in this paper, we study the consequences of imposing both ACRT and dynamic translation on this growth technique. Time-dependent, axisymmetric numerical simulations using moving grid approach have been carried out using finite volume code Ansys Fluent. Crucible translation effect is simulated using dynamic thermal boundary condition. Results are compared to the case in which this growth system is subjected to ACRT only. It is predicted that by combining ACRT with dynamic pulling, excellent axial compositional uniformity can be achieved and growth rate can be improved substantially without significantly compromising on the benefits of employing ACRT. The results show that it is advantageous to utilize the combination of ACRT and dynamic translation during LPD growth rather than using them independently for producing relatively uniform composition SixGe1−x single crystals in a shorter span of time

SIPping from the Data Firehose

When mining large databases, the data extraction problem and the interface between the database and data mining algorithm become important issues. Rather than giving a mining algorithm full access to a database (by extracting to a flat file or other directlyaccessible data structure), we propose the SQL Interface Protocol (SIP), which is a framework for interaction between a mining algorithm and a database. The data continues to reside entirely within the database management system (DBMS), but the query interface to the database gives the data mining algorithm sufficient information to discover the same patterns it would have found with direct access to the data. This model of interaction brings several advantages; for example, it allows a mining algorithm to be parallelized automatically just by using a parallelized DBMS to answer queries. We show how two families of mining algorithms may be implemented as "SIPpers," and we discuss related work in databases that should further enhance..

Directed Improvisation

We introduce "directed improvisation," a new paradigm for human-computer interaction (HCI). Users direct computer "characters" with abstract instructions and constraints. The characters improvise behaviors that follow the directions, express their personal styles, and meet other objectives. We illustrate directed improvisation with our current testbed application, a Computer-Animated Improvisational Theater for children, and discuss its properties as an HCI paradigm. KEYWORDS : Interaction Paradigm, Intelligent systems, Educational applications, Entertainment applications. 1. INTRODUCTION To improvise is to invent, create, or perform a new work in real time, without detailed preparation and often by making use of the resources at hand. Improvisation may be constrained by self-imposed or exogenously supplied directions. The resulting "new work" realizes a prescribed structure in an inventive form. The most striking examples of "directed improvisation" occur in the theater [8, 10, 22,..

Habitat Use by Salt Marsh Birds and Response to Open Marsh Water Management

We examined the numerical responses of salt marsh birds in Massachusetts to modified open marsh water management (OMWM), a habitat alteration technique to control salt marsh mosquitoes without destroying habitat quality for pool-using birds. This management had little overall effect on bird populations in two 3-ha plots monitored for three yearss after manipulation. Shorebirds increased at first, probably owing to use of spoil resulting from construction activities but then decreased to pre-alteration numbers. Other pool-using birds (herons, terns and kingfishers) were not affected by management and consistently used control plots with extensive natural pool systems. Numbers of some marsh- and upland-nesting birds declined temporarily but returned to pre-alteration levels by the end of the study. Results indicate that open water marsh management, as modified in Massachusetts, has little immediate adverse or beneficial effect on salt marsh birds in marshes that have been previously ditched