A Simple But Highly Selective Electrochemical Sensor for Dopamine

A modified platinum electrode was fabricated by the electropolymerization of pyrrole using a sodium p-sulphonatocalix[6]arene as the supporting electrolyte. The modified electrode acts as a reasonably sensitive electrochemical sensor for dopamine giving a linear calibration curve in the range 0.075 – 1.00 mM dopamine. The sensor shows no ability to sense the common interferent ascorbic acid, therefore the concentration for dopamine can be directly sensed in a large excess of ascorbic acid with no need to make adjustments for the signal for ascorbic acid. Investigations are included to study the mode of sensing of the modified electrode

Observations on the distribution of monophasic Salmonella Typhimurium on pig farms in Great Britain

Ten pig herds were visited and intensively sampled to determine the within group prevalence, distribution of contamination and numbers of Salmonella organisms excreted by infected pigs. The distribution of infection was highly variable but on all farms with breeding pigs the breeding herd was involved, even though the occurrence of the organism was greater in growing and fattening pigs. Infection was less common in farrowing areas. Involvement of wild birds and contamination of soil on outdoor units was frequently found

Supply-demand matrix: a process-oriented approach for data warehouses with constellation schemas

Star schema in data warehouses is a very well-established model. However, the increasing number of star schemas creating large constellations schemas add new challenges in the organizations. In this document, we intend to make a contribution in the technical architecture of data warehouses with constellation schemas using an extension of the bus matrix. The proposed supply-demand matrix details the raw data from the original databases, describes the constellation schemas with different dimensions and establishes the information demand requirements.info:eu-repo/semantics/publishedVersio

Quantum signatures of chaos in the dynamics of a trapped ion

We show how a nonlinear chaotic system, the parametrically kicked nonlinear oscillator, may be realised in the dynamics of a trapped, laser-cooled ion, interacting with a sequence of standing wave pulses. Unlike the original optical scheme [G.J.Milburn and C.A.Holmes, Phys. Rev A, 44, p4704, (1991)], the trapped ion enables strongly quantum dynamics with minimal dissipation. This should permit an experimental test of one of the quantum signatures of chaos; irregular collapse and revival dynamics of the average vibrational energy.Comment: 9 pages, 9 Postscript figures, Revtex, submitted to Phys. Rev.

The Flux Variability of Markarian 501 in Very High Energy Gamma Rays

The BL Lacertae object Markarian 501 was identified as a source of gamma-ray emission at the Whipple Observatory in March 1995. Here we present a flux variability analysis on several times-scales of the 233 hour data set accumulated over 213 nights (from March 1995 to July 1998) with the Whipple Observatory 10 m atmospheric Cherenkov imaging telescope. In 1995, with the exception of a single night, the flux from Markarian 501 was constant on daily and monthly time-scales and had an average flux of only 10% that of the Crab Nebula, making it the weakest VHE source detected to date. In 1996, the average flux was approximately twice the 1995 flux and showed significant month-to-month variability. No significant day-scale variations were detected. The average gamma-ray flux above ~350 GeV in the 1997 observing season rose to 1.4 times that of the Crab Nebula -- 14 times the 1995 discovery level -- allowing a search for variability on time-scales shorter than one day. Significant hour-scale variability was present in the 1997 data, with the shortest, observed on MJD 50607, having a doubling time of ~2 hours. In 1998 the average emission level decreased considerably from that of 1997 (to ~20% of the Crab Nebula flux) but two significant flaring events were observed. Thus, the emission from Markarian 501 shows large amplitude and rapid flux variability at very high energies as does Markarian 421. It also shows large mean flux level variations on year-to-year time-scales, behaviour which has not been seen from Markarian 421 so far.Comment: 19 pages, 3 figures, to appear in ApJ, June 20, 1999, Vol. 518 #

Explaining the rise of 'human rights' in analyses of Sino-African relations

Popular perceptions of China and its global role are often shaped by two words: 'made in'. Yet this vision of China that focuses primarily on Beijing as a coming economic superpower is relatively new, and it is not that long ago that two other words tended to dominate debates on and discourses of China: 'human rights'. To be sure, real interest in human rights in China was never the only issue in other states' relations with China, nor consistently pursued throughout the years (Nathan, 1994). Nor did human rights totally subsequently disappear from the political agenda.1 Nevertheless, the rhetorical importance of human rights - perhaps best epitomised by the narrow defeat of resolutions condemning Chinese policy in 1995 at the Human Rights Council in Geneva - stands in stark contrast to the relative silence thereafter as the bottom line of most states' relations with Beijing took on ever greater economic dimensions

Bitterness suppression with zinc sulfate and na-cyclamate: a model of combined peripheral and central neural approaches to flavor modification

Purpose Zinc sulfate is known to inhibit the bitterness of the antimalarial agent quinine [R. S. J. Keast. The effect of zinc on human taste perception. J. Food Sci. 68:1871&ndash;1877 (2003)]. In the present work, we investigated whether zinc sulfate would inhibit other bitter-tasting compounds and pharmaceuticals. The utility of zinc as a general bitterness inhibitor is compromised, however, by the fact that it is also a good sweetness inhibitor [R. S. J. Keast, T. Canty, and P. A. S. Breslin. Oral zinc sulfate solutions inhibit sweet taste perception. Chem. Senses 29:513&ndash;521 (2004)] and would interfere with the taste of complex formulations. Yet, zinc sulfate does not inhibit the sweetener Na-cyclamate. Thus, we determined whether a mixture of zinc sulfate and Na-cyclamate would be a particularly effective combination for bitterness inhibition (Zn) and masking (cyclamate). Method We used human taste psychophysical procedures with chemical solutions to assess bitterness blocking. Results Zinc sulfate significantly inhibited the bitterness of quinine&ndash;HCl, Tetralone, and denatonium benzoate (DB) (p &lt; 0.05), but had no significant effect on the bitterness of sucrose octa-acetate, pseudoephedrine (PSE), and dextromethorphan. A second experiment examined the influence of zinc sulfate on bittersweet mixtures. The bitter compounds were DB and PSE, and the sweeteners were sucrose (inhibited by 25 mM zinc sulfate) and Na-cyclamate (not inhibited by zinc sulfate). The combination of zinc sulfate and Na-cyclamate most effectively inhibited DB bitterness (86%) (p &lt; 0.0016), whereas the mixture\u27s inhibition of PSE bitterness was not different from that of Na-cyclamate alone. Conclusion A combination of Na-cyclamate and zinc sulfate was most effective at inhibiting bitterness. Thus, the combined use of peripheral oral and central cognitive bitterness reduction strategies should be particularly effective for improving the flavor profile of bitter-tasting foods and pharmaceutical formulations. <br /

Identifying the mechanisms underpinning recognition of structured sequences of action

© 2012 The Experimental Psychology SocietyWe present three experiments to identify the specific information sources that skilled participants use to make recognition judgements when presented with dynamic, structured stimuli. A group of less skilled participants acted as controls. In all experiments, participants were presented with filmed stimuli containing structured action sequences. In a subsequent recognition phase, participants were presented with new and previously seen stimuli and were required to make judgements as to whether or not each sequence had been presented earlier (or were edited versions of earlier sequences). In Experiment 1, skilled participants demonstrated superior sensitivity in recognition when viewing dynamic clips compared with static images and clips where the frames were presented in a nonsequential, randomized manner, implicating the importance of motion information when identifying familiar or unfamiliar sequences. In Experiment 2, we presented normal and mirror-reversed sequences in order to distort access to absolute motion information. Skilled participants demonstrated superior recognition sensitivity, but no significant differences were observed across viewing conditions, leading to the suggestion that skilled participants are more likely to extract relative rather than absolute motion when making such judgements. In Experiment 3, we manipulated relative motion information by occluding several display features for the duration of each film sequence. A significant decrement in performance was reported when centrally located features were occluded compared to those located in more peripheral positions. Findings indicate that skilled participants are particularly sensitive to relative motion information when attempting to identify familiarity in dynamic, visual displays involving interaction between numerous features

Effects of noise on quantum error correction algorithms

It has recently been shown that there are efficient algorithms for quantum computers to solve certain problems, such as prime factorization, which are intractable to date on classical computers. The chances for practical implementation, however, are limited by decoherence, in which the effect of an external environment causes random errors in the quantum calculation. To combat this problem, quantum error correction schemes have been proposed, in which a single quantum bit (qubit) is ``encoded'' as a state of some larger number of qubits, chosen to resist particular types of errors. Most such schemes are vulnerable, however, to errors in the encoding and decoding itself. We examine two such schemes, in which a single qubit is encoded in a state of $n$ qubits while subject to dephasing or to arbitrary isotropic noise. Using both analytical and numerical calculations, we argue that error correction remains beneficial in the presence of weak noise, and that there is an optimal time between error correction steps, determined by the strength of the interaction with the environment and the parameters set by the encoding.Comment: 26 pages, LaTeX, 4 PS figures embedded. Reprints available from the authors or http://eve.physics.ox.ac.uk/QChome.htm

Multiwavelength Observations of a Flare from Markarian 501

We present multiwavelength observations of the BL Lacertae object Markarian 501 (Mrk 501) in 1997 between April 8 and April 19. Evidence of correlated variability is seen in very high energy (VHE, E > 350 GeV) gamma-ray observations taken with the Whipple Observatory gamma-ray telescope, data from the Oriented Scintillation Spectrometer Experiment of the Compton Gamma-Ray Observatory, and quicklook results from the All-Sky Monitor of the Rossi X-ray Timing Explorer while the Energetic Gamma-Ray Experiment Telescope did not detect Mrk 501. Short term optical correlations are not conclusive but the U-band flux observed with the 1.2m telescope of the Whipple Observatory was 10% higher than in March. The average energy output of Mrk 501 appears to peak in the 2 keV to 100 keV range suggesting an extension of the synchrotron emission to at least 100 keV, the highest observed in a blazar and ~100 times higher than that seen in the other TeV-emitting BL Lac object, Mrk 421. The VHE gamma-ray flux observed during this period is the highest ever detected from this object. The VHE gamma-ray energy output is somewhat lower than the 2-100 keV range but the variability amplitude is larger. The correlations seen here do not require relativistic beaming of the emission unless the VHE spectrum extends to >5 TeV.Comment: 10 pages, 2 figures, accepted for publication in ApJ Letter