Heteros tis eimi: On the Language of Menander's Young Lovers

published or submitted for publicatio

A Gleaming Ray: Blessed Afterlife in the Mysteries

published or submitted for publicatio

Zeus’ Missing Ears

In his treatise On Isis and Osiris, Plutarch tries to explain the meaning of a statue or image (ἄγαλμα) of Zeus in Crete, which had no ears. An Egyptian or Egyptianizing image with separate ears, perhaps on a stele, incomprehensible to Greeks, but common in Egypt, might have given rise to Plutarch’s bafflement and fantasy interpretation.Dans son traité De Iside et Osiride, Plutarque essaie d’expliquer la signification d’une statue ou d’une image de Zeus (ἄγαλμα) en Crète, qui n’avait aucune oreille. Une image égyptienne ou « égyptianisante » avec des oreilles séparées, peut-être sur une stèle, incompréhensible aux Grecs mais commune en Égypte, pourrait avoir provoqué la perplexité de Plutarque et son interprétation fantaisiste

Lead optimization of a pyrazole sulfonamide series of trypanosoma brucei N -myristoyltransferase inhibitors:Identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human african trypanosomiasis

[Image: see text] Trypanosoma bruceiN-myristoyltransferase (TbNMT) is an attractive therapeutic target for the treatment of human African trypanosomiasis (HAT). From previous studies, we identified pyrazole sulfonamide, DDD85646 (1), a potent inhibitor of TbNMT. Although this compound represents an excellent lead, poor central nervous system (CNS) exposure restricts its use to the hemolymphatic form (stage 1) of the disease. With a clear clinical need for new drug treatments for HAT that address both the hemolymphatic and CNS stages of the disease, a chemistry campaign was initiated to address the shortfalls of this series. This paper describes modifications to the pyrazole sulfonamides which markedly improved blood–brain barrier permeability, achieved by reducing polar surface area and capping the sulfonamide. Moreover, replacing the core aromatic with a flexible linker significantly improved selectivity. This led to the discovery of DDD100097 (40) which demonstrated partial efficacy in a stage 2 (CNS) mouse model of HAT

Plutarch's Erotikos: The Drag Down Pulled Up

published or submitted for publicatio