1,947 research outputs found
A patient preference study that evaluated fluticasone furoate and mometasone furoate nasal sprays for allergic rhinitis
Background: Corticosteroid nasal sprays are the mainstay of treatment for allergic rhinitis. These sprays have sensory attributes such as scent and/or odor, taste and aftertaste, and run down the throat and/or the nose, which, when unpleasant, can affect patient preference for, and compliance with, treatment.
Objective: This study examined patient preference for fluticasone furoate nasal spray (FFNS) or mometasone furoate nasal spray (MFNS) based on their sensory attributes after administration in patients with allergic rhinitis.
Methods: This was a multicenter, randomized, double-blind, cross-over study. Patient preferences were determined by using three questionnaires (Overall Preference, Immediate Attributes, and Delayed Attributes).
Results: Overall, 56% of patients stated a preference for FFNS versus 32% for MFNS (p _ 0.001); the remaining 12% stated no preference. More patients stated a preference for FFNS versus MFNS for the attributes of “less drip down the throat” (p _ 0.001), “less run out of the nose” (p _ 0.05), “more soothing” (p _ 0.05), and “less irritating” (p _ 0.001). More patients responded in favor of FFNS versus MFNS for the immediate attributes, “run down the throat” (p _ 0.001), and “run out of the nose” (p _ 0.001), and, in the delayed attributes, “run down the throat” (p _ 0.001), “run out of the nose” (p _ 0.01), “presence of aftertaste” (p _ 0.01), and “no nasal irritation” (p _ 0.001).
Conclusion: Patients with allergic rhinitis preferred FFNS versus MFNS overall and based on a number of individual attributes, including “less drip down the throat,” “less run out of the nose,” and “less irritating.” Greater preference may improve patient adherence and thereby improve symptom management of the patient’s allergic rhinitis
The partially alternating ternary sum in an associative dialgebra
The alternating ternary sum in an associative algebra, , gives rise to the partially alternating ternary sum in an
associative dialgebra with products and by making the
argument the center of each term: . We use computer algebra to determine the polynomial identities in
degree satisfied by this new trilinear operation. In degrees 3 and 5 we
obtain and ; these identities define a new variety of partially alternating ternary
algebras. We show that there is a 49-dimensional space of multilinear
identities in degree 7, and we find equivalent nonlinear identities. We use the
representation theory of the symmetric group to show that there are no new
identities in degree 9.Comment: 14 page
Whole body and splanchnic amino acid metabolism in sheep during an acute endotoxin challenge
Acknowledgements The expertise of A. Graham Calder and Susan Anderson for the various stable isotope analyses is gratefully recognised. Ngaire Dennison is also thanked for her surgical expertise with the trans-splanchnic tissue catheter preparations. This study was supported by funds provided to the Rowett Institute of Nutrition and Health, University of Aberdeen and Biomathematics and Statistics Scotland by the Rural and Environment Science and Analytical Services Division of the Scottish Government. S. O. H. was a recipient of a FoRST (NZ) award to study abroad.Peer reviewedPostprin
An Arbitrary Two-qubit Computation In 23 Elementary Gates
Quantum circuits currently constitute a dominant model for quantum
computation. Our work addresses the problem of constructing quantum circuits to
implement an arbitrary given quantum computation, in the special case of two
qubits. We pursue circuits without ancilla qubits and as small a number of
elementary quantum gates as possible. Our lower bound for worst-case optimal
two-qubit circuits calls for at least 17 gates: 15 one-qubit rotations and 2
CNOTs. To this end, we constructively prove a worst-case upper bound of 23
elementary gates, of which at most 4 (CNOT) entail multi-qubit interactions.
Our analysis shows that synthesis algorithms suggested in previous work,
although more general, entail much larger quantum circuits than ours in the
special case of two qubits. One such algorithm has a worst case of 61 gates of
which 18 may be CNOTs. Our techniques rely on the KAK decomposition from Lie
theory as well as the polar and spectral (symmetric Shur) matrix decompositions
from numerical analysis and operator theory. They are related to the canonical
decomposition of a two-qubit gate with respect to the ``magic basis'' of
phase-shifted Bell states, published previously. We further extend this
decomposition in terms of elementary gates for quantum computation.Comment: 18 pages, 7 figures. Version 2 gives correct credits for the GQC
"quantum compiler". Version 3 adds justification for our choice of elementary
gates and adds a comparison with classical library-less logic synthesis. It
adds acknowledgements and a new reference, adds full details about the 8-gate
decomposition of topC-V and stealthily fixes several minor inaccuracies.
NOTE: Using a new technique, we recently improved the lower bound to 18 gates
and (tada!) found a circuit decomposition that requires 18 gates or less.
This work will appear as a separate manuscrip
Validation of Methods to Predict Vibration of a Panel in the Near Field of a Hot Supersonic Rocket Plume
This paper describes the measurement and analysis of surface fluctuating pressure level (FPL) data and vibration data from a plume impingement aero-acoustic and vibration (PIAAV) test to validate NASA s physics-based modeling methods for prediction of panel vibration in the near field of a hot supersonic rocket plume. For this test - reported more fully in a companion paper by Osterholt & Knox at 26th Aerospace Testing Seminar, 2011 - the flexible panel was located 2.4 nozzle diameters from the plume centerline and 4.3 nozzle diameters downstream from the nozzle exit. The FPL loading is analyzed in terms of its auto spectrum, its cross spectrum, its spatial correlation parameters and its statistical properties. The panel vibration data is used to estimate the in-situ damping under plume FPL loading conditions and to validate both finite element analysis (FEA) and statistical energy analysis (SEA) methods for prediction of panel response. An assessment is also made of the effects of non-linearity in the panel elasticity
Surface-acoustic-wave-driven luminescence from a lateral p-n junction
The authors report surface-acoustic-wave-driven luminescence from a lateral
p-n junction formed by molecular beam epitaxy regrowth of a modulation doped
GaAs/AlGaAs quantum well on a patterned GaAs substrate.
Surface-acoustic-wave-driven transport is demonstrated by peaks in the
electrical current and light emission from the GaAs quantum well at the
resonant frequency of the transducer. This type of junction offers high carrier
mobility and scalability. The demonstration of surface-acoustic-wave
luminescence is a significant step towards single-photon applications in
quantum computation and quantum cryptography.Comment: 4 pages, 3 figure
Lie group weight multiplicities from conformal field theory
Dominant weight multiplicities of simple Lie groups are expressed in terms of
the modular matrices of Wess-Zumino-Witten conformal field theories, and
related objects. Symmetries of the modular matrices give rise to new relations
among multiplicities. At least for some Lie groups, these new relations are
strong enough to completely fix all multiplicities.Comment: 12 pages, Plain TeX, no figure
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