Characterization and Compensation of Thermal Effects in GaN HEMT Technologies

Further advancements with GaN based technologies relies on the ability to handle the heat flux, which consequently arises from the high power density. Advanced cooling techniques and thermal optimization of the technology are therefore prioritized research areas. Characterization techniques play a key role in the development of new cooling solutions, since these rely on accurate measurements of e.g. the temperature of the device. This thesis covers techniques to electrically characterize the lateral and vertical heat properties in GaN, and a temperature compensation technique for GaN MMICs.The first part outlines a methodology to electrically extract the thermal resistance of a GaN resistor without risking distortion from field induced electron trapping effects, which are exhibited by GaN heterostructures. The technique uses differential resistance measurements to identify a suitable resistor geometry, which minimizes trapping effects while enhancing the self-heating. Such conditions are crucial for electrical methods since these exploit the self- heating for a thermal analysis.Furthermore, a test structure and measurement method to electrically characterize the lateral heat spread was designed and evaluated. The structure is implemented with a thermal sensor, which utilizes the temperature-dependent IV characteristics of a GaN resistor, making it suitable for integration in GaN MMICs. The transient response can be obtained to extract the thermal time constants and propagation delay of the heat spread. At higher ambient temperatures, the propagation delay increases and the thermal coupling is increased. Lastly, a biasing technique to compensate for thermal degradation of the RF performance of an LNA was developed. By utilizing the gate- and drain voltage dependence of the RF performance, a constant gain against increasing temperature can e.g. be achieved

The effective conductivity of arrays of squares: large random unit cells and extreme contrast ratios

An integral equation based scheme is presented for the fast and accurate computation of effective conductivities of two-component checkerboard-like composites with complicated unit cells at very high contrast ratios. The scheme extends recent work on multi-component checkerboards at medium contrast ratios. General improvement include the simplification of a long-range preconditioner, the use of a banded solver, and a more efficient placement of quadrature points. This, together with a reduction in the number of unknowns, allows for a substantial increase in achievable accuracy as well as in tractable system size. Results, accurate to at least nine digits, are obtained for random checkerboards with over a million squares in the unit cell at contrast ratio 10^6. Furthermore, the scheme is flexible enough to handle complex valued conductivities and, using a homotopy method, purely negative contrast ratios. Examples of the accurate computation of resonant spectra are given.Comment: 28 pages, 11 figures, submitted to J. Comput. Phy

Relational autonomy in the care of the vulnerable: health care professionals' reasoning in Moral Case Deliberation (MCD)

In Moral Case Deliberation (MCD), healthcare professionals discuss ethically difficult patient situations in their daily practice. There is a lack of knowledge regarding the content of MCD and there is a need to shed light on this ethical reflection in the midst of clinical practice. Thus, the aim of the study was to describe the content of healthcare professionals' moral reasoning during MCD. The design was qualitative and descriptive, and data consisted of 22 audio-recorded inter-professional MCDs, analysed with content analysis. The moral reasoning centred on how to strike the balance between personal convictions about what constitutes good care, and the perceived dissonant care preferences held by the patient. The healthcare professionals deliberated about good care in relation to demands considered to be unrealistic, justifications for influencing the patient, the incapacitated patient's nebulous interests, and coping with the conflict between using coercion to achieve good while protecting human dignity. Furthermore, as a basis for the reasoning, the healthcare professionals reflected on how to establish a responsible relationship with the vulnerable person. This comprised acknowledging the patient as a susceptible human being, protecting dignity and integrity, defining their own moral responsibility, and having patience to give the patient and family time to come to terms with illness and declining health. The profound struggle to respect the patient's autonomy in clinical practice can be understood through the concept of relational autonomy, to try to secure both patients' influence and at the same time take responsibility for their needs as vulnerable humans

Suspicion and treatment of severe sepsis. An overview of the prehospital chain of care

Sepsis is a life-threatening condition where the risk of death has been reported to be even higher than that associated with the major complications of atherosclerosis, i.e. myocardial infarction and stroke. In all three conditions, early treatment could limit organ dysfunction and thereby improve the prognosis

Lineage 2 West Nile Virus as Cause of Fatal Neurologic Disease in Horses, South Africa

Lineage 2 WNV may be missed as a cause of neurologic infections in horses and humans in this region

GRB 020410: A Gamma-Ray Burst Afterglow Discovered by its Supernova Light

We present the discovery and monitoring of the optical transient (OT) associated with GRB 020410. The fading OT was found by Hubble Space Telescope (HST) observations taken 28 and 65 days after burst at a position consistent with the X-ray afterglow. Subsequent re-examination of early ground based observations revealed that a faint OT was present 6 hours after burst, confirming the source association with GRB 020410. A deep non-detection after one week requires that the OT re-brightened between day 7 and day 28, and further late time HST data taken approximately 100 days after burst imply that it is very red.We compare both the flux and color of the excess with supernova models and show that the data are best explained by the presence of a Type Ib/c supernova at a redshift z ~ 0.5, which occured roughly coincident with the day of GRB.Comment: 23 Pages, 9 figures, submitted to Ap

Disruption of tuftelin 1, a desmosome associated protein, causes skin fragility, woolly hair and palmoplantar keratoderma

Desmosomes are dynamic complex protein structures involved in cellular adhesion. Disruption of these structures by loss of function variants in desmosomal genes lead to a variety of skin and heart related phenotypes. Here, we report tuftelin 1 as a desmosome-associated protein, implicated in epidermal integrity. In two siblings with mild skin fragility, woolly hair and mild palmoplantar keratoderma, but without a cardiac phenotype, we identified a homozygous splice site variant in the TUFT1 gene, leading to aberrant mRNA splicing and loss of tuftelin 1 protein. Patients' skin and keratinocytes showed acantholysis, perinuclear retraction of intermediate filaments, and reduced mechanical stress resistance. Immunolabeling and transfection studies showed that tuftelin 1 is positioned within the desmosome and its location dependent on the presence of the desmoplakin carboxy-terminal tail. A Tuft1 knock-out mouse model mimicked the patients' phenotypes. Altogether, this study reveals tuftelin 1 as a desmosome-associated protein, whose absence causes skin fragility, woolly hair and palmoplantar keratoderma

Disruption of tuftelin 1, a desmosome associated protein, causes skin fragility, woolly hair and palmoplantar keratoderma

Desmosomes are dynamic complex protein structures involved in cellular adhesion. Disruption of these structures by loss of function variants in desmosomal genes lead to a variety of skin and heart related phenotypes. Here, we report tuftelin 1 as a desmosome-associated protein, implicated in epidermal integrity. In two siblings with mild skin fragility, woolly hair and mild palmoplantar keratoderma, but without a cardiac phenotype, we identified a homozygous splice site variant in the TUFT1 gene, leading to aberrant mRNA splicing and loss of tuftelin 1 protein. Patients' skin and keratinocytes showed acantholysis, perinuclear retraction of intermediate filaments, and reduced mechanical stress resistance. Immunolabeling and transfection studies showed that tuftelin 1 is positioned within the desmosome and its location dependent on the presence of the desmoplakin carboxy-terminal tail. A Tuft1 knock-out mouse model mimicked the patients' phenotypes. Altogether, this study reveals tuftelin 1 as a desmosome-associated protein, whose absence causes skin fragility, woolly hair and palmoplantar keratoderma.</p