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Reactive amphiphilic graft copolymer coatings applied to poly(vinylidene fluoride) ultrafiltration membranes
Mustard Carbonate Analogues as Sustainable Reagents for the Aminoalkylation of Phenols
The nitrogen mustard gas moiety is present as a basic, amine-containing side chain in numerous pharmacophore scaffolds engaging in crucial interactions with targeted biological macromolecules. Herein, a one-pot synthetic approach for the easy introduction of nitrogen mustard-like moieties through dialkyl carbonate chemistry into different phenolic substrates is reported. The scope and limitations of this reaction as a chlorine-free direct substitution of the phenolic âOH group have been investigated