External Device to Incrementally Skid the Habitat (E-DISH)

A Mars habitat transport system was designed as part of the NASA Mars exploration program. The transport system, the External Device to Incrementally Skid the Habitat (E - DISH), will be used to transport Mars habitats from their landing sites to the colony base and will be detached after unloading. The system requirements for Mars were calculated and scaled for model purposes. Specific model materials are commonly found and recommendations for materials for the Mars design are included

Design and in vitro studies of a needle-type glucose sensor for subcutaneous monitoring

International audienceA new miniaturized glucose oxidase based needle-type glu¬ cose mlcrosensor has been developed for subcutaneous glu¬ cose monitoring. The sensor Is equivalent In shape and size to a 26-gauge needle (0.45-mm o.d.) and can be Implanted with ease without any Incision. The novel configuration greatly facilitates the deposition of enzyme and polymer films so that sensors with characteristics suitable for In vivo use (upper limit of linear range > 15 mM, response time 60%). The sensor response is largely Independent of ox¬ ygen tension In the normal physiological range. It also ex¬ hibits good selectivity against common interferences except for the exogenous drug acetaminophen

Market Share Constraints and the Loss Function in Choice-Based Conjoint Analysis

Choice-based conjoint analysis is a popular marketing research technique to learn about consumers' preferences and to make market share forecasts under various scenarios for product offerings. Managers expect these forecasts to be “realistic” in terms of being able to replicate market shares at some prespecified or “base-case” scenario. Frequently, there is a discrepancy between the recovered and base-case market share. This paper presents a Bayesian decision theoretic approach to incorporating base-case market shares into conjoint analysis via the loss function. Because defining the base-case scenario typically involves a variety of management decisions, we treat the market shares as constraints on what are acceptable answers, as opposed to informative prior information. Our approach seeks to minimize the adjustment of parameters by using additive factors from a normal distribution centered at 0, with a variance as small as possible, but such that the market share constraints are satisfied. We specify an appropriate loss function, and all estimates are formally derived via minimizing the posterior expected loss. We detail algorithms that provide posterior distributions of constrained and unconstrained parameters and quantities of interest. The methods are demonstrated using discrete choice models with simulated data and data from a commercial market research study. These studies indicate that the method recovers base-case market shares without systematically distorting the preference structure from the conjoint experiment.Bayesian decision theory, conjoint analysis, constrained optimization, cross-validation, hierarchical Bayes, loss function, market share prediction, penalized maximum likelihood, posterior risk

The Effect of Attribute Variation on Consumer Choice Consistency

We study the effect of shifts in attribute level differences on consumer choice consistency. Choice consistency is measured as the variance of the random error component in the consumer utility function: the smaller this variance, the higher choice consistency. We hypothesize that due to increased choice difficulty, choice consistency decreases if attribute level differences increase while average utility level differences between alternatives remain the same. In our empirical illustration we focus on the impact of price level shifts on choice consistency in conjoint choice experiments. Our results show that choice consistency decreases as price level differences increase and absolute price levels increase

DNA is replicated at the nuclear cage.

Structures resembling nuclei are released when HeLa cells are lysed in a detergent and 2 M salt. These nucleoids, which lack any organized membrane structure, contain all the nuclear DNA packaged within a cage of RNA and protein. Their DNA is supercoiled so that the linear DNA must remain unbroken and looped during lysis. Following digestion with the restriction endonuclease, EcoRI, cages and associated DNA were filtered free of unattached DNA. Pulse-labelled (i.e. newly synthesized) DNA remains preferentially associated with the cages. This association has been confirmed by autoradiography. When nucleoids are prepared for electron microscopy by the Kleinschmidt procedure the DNA spills out to form a skirt around the flattened cage. Labelling, which is restricted to the region of the cage after short pulses, extends out into the skirt as the labelling time increases. A model, based on the premise that replication takes place at the nuclear cage, is presented in the Appendix. The results of the biochemical experiments and electron microscopy both indicate that the average size of the unit of replication is approximately 2 micrometer. This is about one-quarter the size of the average structural unit - the loop. Therefore sequences in the loop must become attached to the nuclear cage prior to the initiation of DNA synthesis

Review of the distribution, causes for the decline and recommendations for management of the quokka, Setonix brachyurus (Macropodidae: Marsupialia), an endemic macropod marsupial from south-west Western Australia

The former and current distribution of the quokka, Setortix brachyurus, was mapped from published and all available unpublished records. At the time of European settlement the quokka was widespread and abundant and its distribution encompassed an area of approximatelyThe former and current distribution of the quokka, Setortix brachyurus, was mapped from published and all available unpublished records. At the time of European settlement the quokka was widespread and abundant and its distribution encompassed an area of approximately 41 200 km2 of south-west Western Australia inclusive of two offshore islands, Bald Island and Rottnest Island. Historical reports indicated an extensive population decline occurred in the 1930s. The decline continued, with a previously undocumented decline apparent in the period from 1980 to 1992. However, this decline may be an artefact of the time scales used for mapping and may well equate with a previously reported decline lor a suite of south -west mammals in the 1970s. By 1992 the quokka´s distribution had been reduced to an area of approximately 17800 km2. An increased awareness of the presence of the quokka on the mainland has resulted in numerous reportings of quokka presence since 1992, has confimled the existence of several populations at the northern extent of the quokka´´s known geographic range and indicated the cmrent, 2005, distribution to be similar to that in 1992. However, survey and population estimates at six of these mainland locations from the northem jarrah forest indicated low abundance. There have been no population estimates elsewhere on the mainland. Two populations have been reported tiom the Swan Coastal Plain, but neither has been confirmed extant. Predation by the introduced fox, Vulpes vulpes, is implicated as a major cause of the quokka´s initial decline, while ongoing predation, habitat destruction and modification through altered tire regimes have contributed to the continued decline. Specific conservation management actions are recommended, namely: (i) Implementing an active adaptive management program in the northern jarrah forest to determine quokka population response to habitat manipulation through the use of fIre, fox baiting and pig control; (ii) Surveying the Stirling fumge and Green Range populations with emphasis placed on determining population size and population genetic structure; (iii) Surveying the reported occurrences from the Swan Coastal Plain, with emphasis on unambiguously determining presence. If confirmed, priority should he directed to assessing population size and determining the management requirements to ensure persistence of the population; (iv) Surveying southem forest and south coast populations to assess quokka population size, the extent of movement between sllbpopulations and assessment of the range of habitat types used by quokkas. The latter should be combined with spatial analyses of known extant populations and suitable and potentially suitable habitat; (v) Determining the role of tire in establishing and maintaining preferred habitat of southern forest and south coast populations; and (vi) Establishing a program to assess the potential effects from management operations