8,319 research outputs found
Mathematical Models for Estimating the Risk of vCJD Transmission
We present two different simple models for vCJD transmission by blood transfusion. Both models indicate that transfusions alone are unlikely to cause more than a few infections, unless the number of primary cases increases.
To improve our models, future work should pursue data collection, empirical estimation of the model parameters, and examination of the underlying assumptions of our frameworks.
Further improvements could also include examining susceptibility to vCJD infection by age group and iatrogenic infections introduced through surgical instruments. Regarding the latter, it may be worthwhile to conduct experiments to quantify the transmission of prions from an infected surgical instrument after repeated sterilization procedures
The Convective Urca Process with Implicit Two-Dimensional Hydrodynamics
Consideration of the role of the convective flux in the thermodymics of the
convective Urca neutrino loss process in degenerate, convective, quasi-static,
carbon-burning cores shows that the convective Urca process slows down the
convective current around the Urca-shell, but, unlike the "thermal" Urca
process, does not reduce the entropy or temperature for a given convective
volume. Here we demonstrate these effects with two-dimensional numerical
hydrodynamical calculations. These two-dimensional implicit hydrodynamics
calculations invoke an artificial speeding up of the nuclear and weak rates.
They should thus be regarded as indicative, but still qualitative. We find
that, compared to a case with no Urca-active nuclei, the case with Urca effects
leads to a higher entropy in the convective core because the energy released by
nuclear burning is confined to a smaller volume by the effective boundary at
the Urca shell. All else being equal, this will tend to accelerate the
progression to dynamical runaway. We discuss the open issues regarding the
impact of the convective Urca process on the evolution to the "smoldering
phase" and then to dynamical runaway.Comment: 22 pages, 11 figures, accepted for publication in the Astrophysical
Journa
Systematically Asymmetric Heliospheric Magnetic Field: Evidence for a Quadrupole Mode and Non-axisymmetry with Polarity Flip-flops
Recent studies of the heliospheric magnetic field (HMF) have detected
interesting, systematic hemispherical and longitudinal asymmetries which have a
profound significance for the understanding of solar magnetic fields. The in
situ HMF measurements since 1960s show that the heliospheric current sheet
(HCS) is systematically shifted (coned) southward during solar minimum times,
leading to the concept of a bashful ballerina. While temporary shifts can be
considerably larger, the average HCS shift (coning) angle is a few degrees,
less than the tilt of the solar rotation axis. Recent solar
observations during the last two solar cycles verify these results and show
that the magnetic areas in the northern solar hemisphere are larger and their
intensity weaker than in the south during long intervals in the late declining
to minimum phase. The multipole expansion reveals a strong quadrupole term
which is oppositely directed to the dipole term. These results imply that the
Sun has a symmetric quadrupole S0 dynamo mode that oscillates in phase with the
dominant dipole A0 mode. Moreover, the heliospheric magnetic field has a strong
tendency to produce solar tilts that are roughly opposite in longitudinal
phase. This implies is a systematic longitudinal asymmetry and leads to a
"flip-flop" type behaviour in the dominant HMF sector whose period is about 3.2
years. This agrees very well with the similar flip-flop period found recently
in sunspots, as well as with the observed ratio of three between the activity
cycle period and the flip-flop period of sun-like stars. Accordingly, these
results require that the solar dynamo includes three modes, A0, S0 and a
non-axisymmetric mode. Obviously, these results have a great impact on solar
modelling.Comment: 13 pages, 4 figures, Solar Physics, Topical Issue of Space Climate
Symposium, in pres
Cranial ultrasound findings in preterm germinal matrix haemorrhage, sequelae and outcome
Germinal matrix-intraventricular haemorrhage (GMH-IVH), periventricular haemorrhagic infarction (PHI) and its complication, post-haemorrhagic ventricular dilatation (PHVD), are still common neonatal morbidities in preterm infants that are highly associated with adverse neurodevelopmental outcome. Typical cranial ultrasound (CUS) findings of GMH-IVH, PHI and PHVD, their anatomical substrates and underlying mechanisms are discussed in this paper. Furthermore, we propose a detailed descriptive classification of GMH-IVH and PHI that may improve quality of CUS reporting and prediction of outcome in infants suffering from GMH-IVH/PHI
Bioconversion of polyphenols and organic acids by gut microbiota of predigested Hibiscus sabdariffa L. calyces and Agave (A. tequilana Weber) fructans assessed in a dynamic in vitro model (TIM-2) of the human colon
The present work aimed at understanding gut microbiota bioconversion of phenolic compounds (PC) and organic acids in predigested Hibiscus sabdariffa (Hb) calyces and the mixture of Hb and Agave (Agave tequilana Weber) fructans (AF). With this purpose, dried Hb and Hb/AF were predigested with enzymatic treatment, and then fermented in a dynamic in vitro model of the human colon (TIM-2). After HPLC-ESI-QToF-MS analysis of samples taken at 0, 24, 48 and 72 h of fermentation, it was observed that hydroxycinnamic acids, flavanols, flavonols, and anthocyanins were mainly transformed into derivatives of hydroxyphenylpropionic, hydroxyphenylacetic and hydroxybenzoic acids. Moreover, organic acids, such as hydroxycitric and hibiscus acids, were formed along with unidentified lactones and reduced compounds. Interestingly, no differences were observed between microbial-derived metabolites formed after the fermentation of Hb and Hb/AF. In conclusion, colonic fermentation of polyphenol-rich Hb yields a wide range of microbial phenolic metabolites with potential effects on health.RMB and SGSA acknowledge to Science and Technology for Development Program (CYTED) through the Ibero-American Network of Underutilized Autonomous Foods (ALSUB-CYTED, 118RT0543). SGSA acknowledges CONACYT-Mexico for the sabbatical grant 260935. The Spanish Ministry of Science, Innovation and Universities (Project AGL2015-69986-R) is also acknowledged. This research has been made possible with the support of the Dutch Province of Limburg.Peer reviewe
Contributions to the Mammalogy of Mongolia, with a Checklist of Species for the Country
We present accounts for 40 species of mammals collected from 15 localities in the Mongolian People\u27s Republic. Accounts include taxonomic, morphometric, reproductive and ecological information, as well as trap effort and success. In addition, we include a brief history of mammalogical work within Mongolia, a taxonomically updated species list for the country, and a list of institutions with holdings of Mongolian mammals
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