Partition Decoupling for Multi-gene Analysis of Gene Expression Profiling Data

We present the extention and application of a new unsupervised statistical learning technique--the Partition Decoupling Method--to gene expression data. Because it has the ability to reveal non-linear and non-convex geometries present in the data, the PDM is an improvement over typical gene expression analysis algorithms, permitting a multi-gene analysis that can reveal phenotypic differences even when the individual genes do not exhibit differential expression. Here, we apply the PDM to publicly-available gene expression data sets, and demonstrate that we are able to identify cell types and treatments with higher accuracy than is obtained through other approaches. By applying it in a pathway-by-pathway fashion, we demonstrate how the PDM may be used to find sets of mechanistically-related genes that discriminate phenotypes.Comment: Revise

The Impact of Dry Saharan Air on Tropical Cyclone Intensification

The controversial role of the dry Saharan Air Layer (SAL) on tropical storm intensification in the Atlantic will be addressed. The SAL has been argued in previous studies to have potential positive influences on storm development, but most recent studies have argued for a strong suppressing influence on storm intensification as a result of dry air, high stability, increased vertical wind shear, and microphysical impacts of dust. Here, we focus on observations of Hurricane Helene (2006), which occurred during the NASA African Monsoon Multidisciplinary Activities (NAMMA) experiment. Satellite and airborne observations, combined with global meteorological analyses depict the initial environment of Helene as being dominated by the SAL, although with minimal evidence that the SAL air actually penetrated to the core of the disturbance. Over the next several days, the SAL air quickly moved westward and was gradually replaced by a very dry, dust-free layer associated with subsidence. Despite the wrapping of this very dry air around the storm, Helene intensified steadily to a Category 3 hurricane suggesting that the dry air was unable to significantly slow storm intensification. Several uncertainties remain about the role of the SAL in Helene (and in tropical cyclones in general). To better address these uncertainties, NASA will be conducting a three year airborne campaign called the Hurricane and Severe Storm Sentinel (HS3). The HS3 objectives are: To obtain critical measurements in the hurricane environment in order to identify the role of key factors such as large-scale wind systems (troughs, jet streams), Saharan air masses, African Easterly Waves and their embedded critical layers (that help to isolate tropical disturbances from hostile environments). To observe and understand the three-dimensional mesoscale and convective-scale internal structures of tropical disturbances and cyclones and their role in intensity change. The mission objectives will be achieved using two Global Hawk (GH) Unmanned Airborne Systems (UASs) with separate comprehensive environmental and over-storm payloads. The GH flight altitudes (>16.8 km) allow overflights of most convection and sampling of upper-tropospheric winds. Deployments from Goddard s Wallops Flight Facility and ~26-hour flight durations will provide coverage of the entire Atlantic Ocean basin, and on-station times up to 5-22 h depending on storm location. Deployments will be in September of 2012 and from late-August to late- September 2013-2014, with up to eleven 26-h flights per deployment

Re-Evaluating the Role of the Saharan Air Layer in Atlantic Tropical Cyclogenesis and Evolution

The existence of the Saharan air layer (SAL), a layer of warm, dry, dusty air frequently present over the tropical Atlantic Ocean, has long been appreciated. The nature of its impact on hurricanes remains unclear, however, with some researchers arguing that the SAL amplifies hurricane development and with others arguing that it inhibits it. Most research in recent years has emphasized the potential negative impacts of the SAL, but is this emphasis justified? The potential negative impacts of the SAL include 1) vertical wind shear associated with the African easterly jet; 2) warm air aloft, which increases thermodynamic stability at the base of the SAL; and 3) dry air, which produces cold downdrafts. Multiple NASA satellite data sets and NCEP global analyses are used to characterize the SAL's properties and evolution in relation to tropical cyclones and to evaluate these potential negative influences. The results suggest that the negative influences of the SAL have been significantly over-emphasized, in part because of several false assumptions about the structure and role of the SAL

The Standing Wave Phenomenon in Radio Telescopes; Frequency Modulation of the WSRT Primary Beam

Inadequacies in the knowledge of the primary beam response of current interferometric arrays often form a limitation to the image fidelity. We hope to overcome these limitations by constructing a frequency-resolved, full-polarization empirical model for the primary beam of the Westerbork Synthesis Radio Telescope (WSRT). Holographic observations, sampling angular scales between about 5 arcmin and 11 degrees, were obtained of a bright compact source (3C147). These permitted measurement of voltage response patterns for seven of the fourteen telescopes in the array and allowed calculation of the mean cross-correlated power beam. Good sampling of the main-lobe, near-in, and far-side-lobes out to a radius of more than 5 degrees was obtained. A robust empirical beam model was detemined in all polarization products and at frequencies between 1322 and 1457 MHz with 1 MHz resolution. Substantial departures from axi-symmetry are apparent in the main-lobe as well as systematic differences between the polarization properties. Surprisingly, many beam properties are modulated at the 5 to 10% level with changing frequency. These include: (1) the main beam area, (2) the side-lobe to main-lobe power ratio, and (3) the effective telescope aperture. These semi-sinusoidsal modulations have a basic period of about 17 MHz, consistent with the natural 'standing wave' period of a 8.75 m focal distance. The deduced frequency modulations of the beam pattern were verified in an independent long duration observation using compact continuum sources at very large off-axis distances. Application of our frequency-resolved beam model should enable higher dynamic range and improved image fidelity for interferometric observations in complex fields. (abridged)Comment: 12 pages, 11 figures, Accepted for publication in A&A, figures compressed to low resolution; high-resolution version available at: http://www.astro.rug.nl/~popping/wsrtbeam.pd

Simulation of the Genesis of Hurricane Javier (2004) in the Eastern Pacific

NASA is preparing for the Tropical Cloud Systems and Processes (TCSP) field experiment in July 2005, a joint effort with NOAA to study tropical cloud systems and tropical cyclone genesis in the Eastern Pacific. A major thrust of the TCSP program is the improvement of the understanding and prediction of tropical cyclone genesis, intensity, motion, rainfall potential, and landfall impacts using remote sensing and in-situ data, as well as numerical modeling, particularly as they relate to the three phases of water. The Eastern Pacific has the highest frequency of genesis events per unit area of any region worldwide. African easterly waves, mesoscale convective systems (MCSs), and orographic effects are thought to play roles in the genesis of tropical cyclones there. The general consensus is that tropical depressions form in association with one or more mid-level, mesoscale cyclonic vortices that are generated within the stratiform region of the MCS precursors. To create the warm core tropical depression vortex, however, the midlevel cyclonic circulation must somehow extend down to the surface and the tangential winds must attain sufficient strength (-10 m s- ) to enable the wind-induced surface heat exchange to increase the potential energy of the boundary layer air

Space-Based Precipitation Measurements in Tropical Cyclones: Past, Present, and Future

Passive and active remote sensing of precipitation from space has led to significant advances in the understanding and prediction of tropical cyclones around the globe. This presentation will highlight the role of past NASA space-based measurements of precipitation by the Tropical Rainfall Measuring Mission (TRMM, 1998-2015), ongoing measurements by the Global Precipitation Measurement (GPM) mission (2014-current), and future measurements from the Time-Resolved Observations of Precipitation structure and storm Intensity with a Constellation of Smallsats (TROPICS, nominal launch date in 2020) as well as a potential new mission on Aerosols, Clouds, Convection, and Precipitation (ACCP) from the 2017 NASA Earth Science Decadal Survey. TRMM, which flew the first precipitation radar in space, provided the first systematic descriptions of the radial and azimuthal variations of rainfall in tropical cyclones around the globe and their relationship to storm motion and vertical wind shear. GPM is the lynchpin of a global constellation of precipitation satellites that provides high spatial (0.1) and temporal (30 min) resolution real-time estimates of precipitation globally, making them essential to applications related to tropical cyclone prediction, disaster response, flood and landslide monitoring, and vector-borne disease monitoring. TROPICS will be a constellation of 6 Cubesat satellites with microwave imaging and sounding channels that will provide information on temperature and humidity in the storm environment, as well as estimates of precipitation and tropical cyclone intensity. ACCP is yet to be fully defined, but is envisioned to potentially carry multi-frequency radar with possible Doppler capability

Status of Current and Future NASA Precipitation-Related Missions

No abstract availabl

GPM Status and Science

No abstract availabl

Reevaluating the Role of Saharan Air Layer in Atlantic Tropical Cyclogenesis and Evolution

The existence of the Saharan air layer (SAL), a layer of warm, dry, dusty air that frequently moves westward off of the Saharan desert of Africa and over the tropical Atlantic Ocean, has long been appreciated. As air moves over the desert, it is strongly heated from below, producing a very hot air mass at low levels. Because there is no moisture source over the Sahara, the rise in temperature causes a sharp drop in relative humidity, thus drying the air. In addition, the warm air produces a very strong jet of easterly flow in the middle troposphere called the African easterly jet that is thought to play a critical role in hurricane formation. In recent years, there has been an increased focus on the impact that the SAL has on the formation and evolution of hurricanes in the Atlantic. However, the nature of its impact remains unclear, with some researchers arguing that the SAL amplifies hurricane development and with others arguing that it inhibits it. The argument for positively influencing hurricane development is based upon the fact that the African easterly jet provides an energy source for the waves that eventually form hurricanes and that it leads to rising motion south of the jet that favors the development of deep thunderstorm clouds. The potential negative impacts of the SAL include 1) low-level vertical wind shear associated with the African easterly jet; 2) warm SAL air aloft, which increases thermodynamic stability and suppresses cloud development; and 3) dry air, which produces cold downdrafts in precipitating regions, thereby removing energy needed for storm development. As part of this recent focus on the SAL and hurricanes (which motivated a 2006 NASA field experiment), there has been little emphasis on the SAL s potential positive influences and almost complete emphasis on its possible negative influences, almost to the point of claims that the SAL is the major suppressing influence on hurricanes in the Atlantic. In this study, multiple NASA satellite data sets (TRMM, MODIS, CALIPSO, and AIRS/AMSU) and National Centers for Environmental Prediction global analyses are used to see if the proposed negative influences deserve all of the attention they have recently received. The results show that storms generally form on the southern side of the African jet, where favorable background rotation is high. The jet often helps to form the northern side of the storms and is typically stronger in storms that intensify than those that weaken, suggesting that jet-induced vertical wind shear is not a negative influence on developing storms. Warm SAL air is confined to regions north of the jet and generally does not impact the tropical cyclone precipitation south of the jet. A comparison of the environments of strongly strengthening storms and of weakening storms shows no differences in SAL structure, indicating that the SAL has little influence on whether storms weaken or intensify. The large-scale flow at upper levels above the SAL was found to be most important, with the environment of strengthening storms having very little vertical wind shear and also favoring more expansive outflow from the storm. The SAL is shown to occur in a large-scale environment that is already characteristically dry as a result of large-scale subsidence (sinking air motions). Strong surface heating and deep dry convective mixing enhance dryness at low levels, but moisten the air at midlevels. Therefore, mid-to-upper-level dryness is not a defining characteristic of the SAL, but is instead a signature of subsidence. As a result, we conclude that the SAL is not the major negative influence on hurricanes that recent studies have emphasized. It is just one of many possible influences and can be both positive and negative

Multidimensional scaling and equivalence: is having a job the same as working?

"The question of functional equivalence in internationally comparative surveys is discussed from the viewpoint of secondary analysis. A number of data-analytical procedures - ranging from a comparison of means over establishing correlations with third variables in individual countries to Multidimensional Scaling (MDS) - are discussed and used to check problems in functional equivalence in an item battery on gender roles. The data base consists of several national samples (Italian, German, American, British and Hungarian) of the 1988 International Social Survey Programme study on Family and Changing Gender Roles. It is concluded that (1) ex post checking of functional equivalence is useful and necessary because (2) the related problems might have less to do with translation than with ambiguities of the concepts and/or formulations used in source instruments and with differences in the social and economic realities in the respective countries, but that (3) even secondary-analytic strategies are as a rule not conclusive and should be supplemented with methodological experiments." (author's abstract