110 research outputs found

    Literature’s poor relation: history and identity in the writing and criticism of nineteen-fifties literature

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    All the major critics of postwar literature regard the fifties as a period in which literature was inept, conservative and conformist. This thesis argues that fifties literature was instead an active and successful agent in problematising conservative political orthodoxies, and in articulating alternative identities and politics. The study is concerned with two major themes: the relationship between literature and history, and the critical reputation and location of literature in nineteen-fifties Britain. It begins from positions that are already evident in postwar literary criticism towards both of these themes. Literature is understood in much of the critical writing of postwar Britain to be representative of social trends and attitudes, and its meaning is determined largely according to particular understandings of postwar British history and society. The literary text, if understood as 'representative', is capable of offering the reader direct access to the society of its production, and of reflecting the dominant trends and attitudes in a given period. Because it is the most recent period of realism in the history of English literature, the fifties seem to be particularly susceptible to this view. Reading fifties literature in the light of poststructuralist thinking on textuality and representation, this study argues that literature is not representative bu negotiates identities and social experiences of the fifties in a much more diverse way. These negotiations are demonstrated in readings of the work of John Osborne, Brendan Behan and Sam Selvon, and elaborated theoretically in the concluding chapters of the study. Literature's Poor Relation demonstrates that fifties literature is able to manoeuvre into a space wherein it can articulate oppositional and critical stances towards power, by firstly, imitating social detail and literary traditions, and secondly, reading these details and traditions in such was as to deconstruct them. The appearance of representativeness serves to seduce the reader into desiring the text (the idea that Look Back in Anger was representative attracted many of its original audiences to see it), and its readings and interpretations of history and identity deflect the reader's desire towards oppositional and critical moments in the text

    An Investigation of Outsourcing Ticket Sales in Division I College Athletics

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    Understanding the phenomenon of outsourcing ticket sales in collegiate athletics can help athletic departments make more informed ticketing decisions. The purpose of this qualitative phenomenological research study was to help create new and emerging knowledge of outsourcing ticket sales in collegiate athletics from the interactions with the study’s participants. The study had 15 participants who experienced the decision-making process as well as the stakeholder impact of outsourcing ticket sales in collegiate athletics. After doing a thematic analysis of the data, eight final themes were used to help describe the phenomenon. It was clear that the importance of being able to have the resources, training, and guaranteed revenue of outsourcing companies are advantages of partnering with an outsourcing company. These resources also allow other department staff to flourish. However, loss of control, turnover, and having everyone on board was a concern for administrators. Participants described outsourcing ticket sales as something that can help a lot of institutions, especially smaller ones; however, the relationship between the organization needs to be clear and positive for it to work. This study also provides insight on who makes the final decision when it comes to outsourcing. The study will help future researchers discover more about outsourcing ticket sales in collegiate athletics while aiding industry experts on making the most informed decisions

    E.M.B.A. International Field Studies: A Comparative Perspective

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    Almost 80% of EMBA programs include a significant international study experience. The content and process, though, vary considerably in length, location, and method. To provide insight to the scope, format, of different approaches, the researchers conducted extensive interviews with 40 EMBA program directors. Results of the investigation are presented providing information that EMBA directors, faculty and administrators may find useful in improving the quality and effectiveness of their international field studies

    Extended Enterprise Metrics: The Key To Achieving Synthesized Effectiveness

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    In this paper we argue that the Extended Enterprise is a natural response to changing competitive dynamics and is predicated upon adapting some of the traditional performance measures.  We examine how the constructs of the Balanced Scorecard, Economic Profit (or Economic Value Added) and boundary spanning metrics such as the cash-to-cash cycle are useful tools for developing metrics for the Extended Enterprise.  We illustrate that when these measures are jointly adopted they can help to drive the integrating behaviors that epitomize the truly revolutionary Extended Enterprise.  The key phrase here is integrative – what is good for one must be good for all since the true competitive battle is fought supply chain against supply chain

    International Field Studies: Tools For Enhancing Cultural Literacy

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    As part of Loyola College’s Executive MBA Program, students participate in an international field study (IFS).  This IFS provides participants with an experientially based learning opportunity to understand that there are leadership universals that every executive and manager needs to practice in order to be world-class at home and abroad; and to appreciate that valuing and leveraging cultural differences is key to success  in a global environment. This paper presents our approach to enhancing the cultural competency and literacy of students enrolled in the program

    Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel

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    Pentameric ligand-gated ion channels (pLGICs) are essential determinants of synaptic transmission, and are modulated by specific lipids including anionic phospholipids. The exact modulatory effect of anionic phospholipids in pLGICs and the mechanism of this effect are not well understood. Using native mass spectrometry, coarse-grained molecular dynamics simulations and functional assays, we show that the anionic phospholipid, 1-palmitoyl-2-oleoyl phosphatidylglycerol (POPG), preferentially binds to and stabilizes the pLGIC, Erwinia ligand-gated ion channel (ELIC), and decreases ELIC desensitization. Mutations of five arginines located in the interfacial regions of the transmembrane domain (TMD) reduce POPG binding, and a subset of these mutations increase ELIC desensitization. In contrast, a mutation that decreases ELIC desensitization, increases POPG binding. The results support a mechanism by which POPG stabilizes the open state of ELIC relative to the desensitized state by direct binding at specific sites

    A GAIN in understanding autoproteolytic G protein‐coupled receptors and polycystic kidney disease proteins

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    Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102153/1/embj201251.pd

    Insole Antenna for On-Body Telemetry

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    A 433 MHz antenna is proposed for integration with the insole of footwear for a body area network. The folded dipole design with an asymmetric groundplane radiates from its edges and considers the close proximity of the human foot and ground surfaces. It functions for different ground conductivity conditions and an on-body communication link with an Inverted F Antenna in the upper body area was evaluated on a static and dynamic human subject. The antenna solution was compliant with Specific Absorption Rate requirements, remains matched and links with upper-body nodes regardless of the body posture and node location

    Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites

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    Polyunsaturated fatty acids (PUFAs) inhibit pentameric ligand-gated ion channels (pLGICs) but the mechanism of inhibition is not well understood. The PUFA, docosahexaenoic acid (DHA), inhibits agonist responses of the pLGIC, ELIC, more effectively than palmitic acid, similar to the effects observed in the GAB

    Lipid nanodisc scaffold and size alter the structure of a pentameric ligand-gated ion channel

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    Lipid nanodiscs have become a standard tool for studying membrane proteins, including using single particle cryo-electron microscopy (cryo-EM). We find that reconstituting the pentameric ligand-gated ion channel (pLGIC), Erwinia ligand-gated ion channel (ELIC), in different nanodiscs produces distinct structures by cryo-EM. The effect of the nanodisc on ELIC structure extends to the extracellular domain and agonist binding site. Additionally, molecular dynamic simulations indicate that nanodiscs of different size impact ELIC structure and that the nanodisc scaffold directly interacts with ELIC. These findings suggest that the nanodisc plays a crucial role in determining the structure of pLGICs, and that reconstitution of ion channels in larger nanodiscs may better approximate a lipid membrane environment
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