A prospective follow up of serum uric acid levels in school children

Na dvije kontrole, u razmaku od tri godine, odre­đena je razina mokraćne kiseline u serumima 381 učenika (starih prosječno 11,4 odnosno 14,3 godine). Uz to su ispitivani i brojni drugi parametri (broj eritrocita, MCV, MCH, MCHC, trigliceridi, holesterol itd.), od kojih je analiziran odnos mokraćne kiseline i tjelesne težine. Analiziran je i odnos navedenih parametara prema istim, dobivenim u ranijem radu, u kom su ispitivana djeca stara 6,4 godine (prvi razred osnovne škole). Nađen je statistički značajan porast razine mokraćne kiseline u dječaka starih 14,4 godine te pojava korelacije razine mokraćne kiseline i tjelesne težine u oba spola (r = 0,35) te dobi (nasuprot manjku te povezanosti u mlađih dobnih skupina djece od 6,4, odnosno 11,4 godine starosti).In 381 children serum uric acid levels were measured at the age of 11.4 and 14.3. Numerous other parameters were also measured (as the erythrocytes, MCV, MCH, MCHC, tryglicerides, cholesterol etc) but only the relation among uric acid levels and body weight was analysed. The relation of these parameters and the data we have got in our previous work (in first grade elementary school children aged 6.4 years) is also discussed. We found significant increase of uric acid levels in boys aged 14.4 and an association between the serum uric acid levels and the body weight appears in both sexes at this age (r=0.35). (Opposite to the lack of this association in younger children, aged 6.4, and 11.4)

A prospective follow up of serum uric acid levels in school children

Na dvije kontrole, u razmaku od tri godine, odre­đena je razina mokraćne kiseline u serumima 381 učenika (starih prosječno 11,4 odnosno 14,3 godine). Uz to su ispitivani i brojni drugi parametri (broj eritrocita, MCV, MCH, MCHC, trigliceridi, holesterol itd.), od kojih je analiziran odnos mokraćne kiseline i tjelesne težine. Analiziran je i odnos navedenih parametara prema istim, dobivenim u ranijem radu, u kom su ispitivana djeca stara 6,4 godine (prvi razred osnovne škole). Nađen je statistički značajan porast razine mokraćne kiseline u dječaka starih 14,4 godine te pojava korelacije razine mokraćne kiseline i tjelesne težine u oba spola (r = 0,35) te dobi (nasuprot manjku te povezanosti u mlađih dobnih skupina djece od 6,4, odnosno 11,4 godine starosti).In 381 children serum uric acid levels were measured at the age of 11.4 and 14.3. Numerous other parameters were also measured (as the erythrocytes, MCV, MCH, MCHC, tryglicerides, cholesterol etc) but only the relation among uric acid levels and body weight was analysed. The relation of these parameters and the data we have got in our previous work (in first grade elementary school children aged 6.4 years) is also discussed. We found significant increase of uric acid levels in boys aged 14.4 and an association between the serum uric acid levels and the body weight appears in both sexes at this age (r=0.35). (Opposite to the lack of this association in younger children, aged 6.4, and 11.4)

Guidelines for treatment of atopic dermatitis

Atopijski dermatitis česta je, kronično recidivirajuća upalna bolest kože karakterizirana složenom etiopatogenezom i raznolikim kliničkim fenotipom. Klinička slika može biti različita, a bolest je obilježena ponavljajućim dermatitisom, izraženim svrbežom i značajnim utjecajem na kvalitetu života oboljele osobe i cijele obitelji. Dijagnoza se postavlja na temelju kliničke slike prema standardiziranim dijagnostičkim kriterijima, a procjena težine bolesti prema standardiziranim instrumentima za procjenu težine bolesti. Liječenje treba prilagoditi svakom bolesniku, a cilj liječenja je smanjiti simptome svrbeža, obnoviti oštećenu kožnu barijeru, spriječiti egzacerbaciju bolesti, spriječiti odnosno liječiti komplikacije i komorbiditete te smanjiti negativni utjecaj bolesti na kvalitetu života. Zahvaljujući napretku u razumijevanju etiopatogeneze, terapijske mogućnosti su zadnjih godina značajno napredovale. Hrvatsko dermatovenerološko društvo Hrvatskoga liječničkog zbora predstavlja smjernice za dijagnostiku i liječenje atopijskog dermatitisa. Smjernice su rezultat konsenzusa hrvatskih stručnjaka za atopijski dermatitis koji su kritički proučili mjerodavnu znanstvenu literaturu, koja se temelji na najboljim dokazima.Atopic dermatitis is a common, chronically recurrent inflammatory skin disease characterized by a complex etiopathogenesis and a variable clinical phenotype. The clinical presentation is heterogeneous, and the disease is characterized by a recurrent dermatitis, intense itching and a significant impact on the quality of life of patients and their family. The diagnosis is based on the clinical presentation according to the standardized diagnostic criteria, while the assessment of disease severity of the disease is based on the standardized tools for disease severity assessment. Treatment should be tailored to each patient profile, and the goal of the treatment is focused on decreasing symptoms and renewing damaged skin barrier, preventing the exacerbation of the disease and preventing or treating the complications and comorbidities, and decreasing the negative influence of the disease on the patient’s quality of life. Due to progress in understanding the etiopathogenesis, treatment options have significantly expanded in the past years. The Croatian Society of Dermatovenerology of the Croatian Medical Association is presenting guidelines for diagnosis and treatment of atopic dermatitis. These guidelines are the result of consensus of Croatian experts based on critical analysis of relevant, evidence-based scientific literature

Guidelines for treatment of atopic dermatitis

Atopijski dermatitis česta je, kronično recidivirajuća upalna bolest kože karakterizirana složenom etiopatogenezom i raznolikim kliničkim fenotipom. Klinička slika može biti različita, a bolest je obilježena ponavljajućim dermatitisom, izraženim svrbežom i značajnim utjecajem na kvalitetu života oboljele osobe i cijele obitelji. Dijagnoza se postavlja na temelju kliničke slike prema standardiziranim dijagnostičkim kriterijima, a procjena težine bolesti prema standardiziranim instrumentima za procjenu težine bolesti. Liječenje treba prilagoditi svakom bolesniku, a cilj liječenja je smanjiti simptome svrbeža, obnoviti oštećenu kožnu barijeru, spriječiti egzacerbaciju bolesti, spriječiti odnosno liječiti komplikacije i komorbiditete te smanjiti negativni utjecaj bolesti na kvalitetu života. Zahvaljujući napretku u razumijevanju etiopatogeneze, terapijske mogućnosti su zadnjih godina značajno napredovale. Hrvatsko dermatovenerološko društvo Hrvatskoga liječničkog zbora predstavlja smjernice za dijagnostiku i liječenje atopijskog dermatitisa. Smjernice su rezultat konsenzusa hrvatskih stručnjaka za atopijski dermatitis koji su kritički proučili mjerodavnu znanstvenu literaturu, koja se temelji na najboljim dokazima.Atopic dermatitis is a common, chronically recurrent inflammatory skin disease characterized by a complex etiopathogenesis and a variable clinical phenotype. The clinical presentation is heterogeneous, and the disease is characterized by a recurrent dermatitis, intense itching and a significant impact on the quality of life of patients and their family. The diagnosis is based on the clinical presentation according to the standardized diagnostic criteria, while the assessment of disease severity of the disease is based on the standardized tools for disease severity assessment. Treatment should be tailored to each patient profile, and the goal of the treatment is focused on decreasing symptoms and renewing damaged skin barrier, preventing the exacerbation of the disease and preventing or treating the complications and comorbidities, and decreasing the negative influence of the disease on the patient’s quality of life. Due to progress in understanding the etiopathogenesis, treatment options have significantly expanded in the past years. The Croatian Society of Dermatovenerology of the Croatian Medical Association is presenting guidelines for diagnosis and treatment of atopic dermatitis. These guidelines are the result of consensus of Croatian experts based on critical analysis of relevant, evidence-based scientific literature