A Reevaluation of the Vestibulo-Ocular Reflex: New Ideas of its Purpose, Properties, Neural Substrate, and Disorders

Conventional views of the Vestibulo-Ocular Reflex (VOR) have emphasized testing with caloric stimuli and by passively rotating patients at low frequencies in a chair. The properties of the VOR tested under these conditions differ from the performance of this reflex during the natural function for which it evolved-locomotion. Only the VOR (and not visually mediated eye movements) can cope with the high-frequency angular and linear perturbations of the head that occur during locomotion; this is achieved by generating eye movements at short latency (less than 16 msec). Interpretation of vestibular testing is enhanced by the realization that, although the di- and trisynaptic components of the VOR are essential for this short-latency response, the overall accuracy and plasticity of the VOR depend upon a distributed, parallel network of neurons involving the vestibular nuclei. Neurons in this network variously encode inputs from the labyrinthine semicircular canals and otoliths, as well as from the visual and somatosensory systems. The central vestibular pathways branch to contact vestibular cortex (for perception) and the spinal cord (for control of posture). Thus, the vestibular nuclei basically coordinate the stabilization of gaze and posture, and contribute to the perception of verticality and self-motion. Consequently, brainstem disorders that disrupt the VOR cause not just only nystagmus, but also instability of posture (eg, increased fore-aft sway in patients with downbeat nystagmus) and disturbance of spatial orientation (eg, tilt of the subjective visual vertical in Wallenberg's syndrome)

Response of thin-film SQUIDs to applied fields and vortex fields: Linear SQUIDs

In this paper we analyze the properties of a dc SQUID when the London penetration depth \lambda is larger than the superconducting film thickness d. We present equations that govern the static behavior for arbitrary values of \Lambda = \lambda^2/d relative to the linear dimensions of the SQUID. The SQUID's critical current I_c depends upon the effective flux \Phi, the magnetic flux through a contour surrounding the central hole plus a term proportional to the line integral of the current density around this contour. While it is well known that the SQUID inductance depends upon \Lambda, we show here that the focusing of magnetic flux from applied fields and vortex-generated fields into the central hole of the SQUID also depends upon \Lambda. We apply this formalism to the simplest case of a linear SQUID of width 2w, consisting of a coplanar pair of long superconducting strips of separation 2a, connected by two small Josephson junctions to a superconducting current-input lead at one end and by a superconducting lead at the other end. The central region of this SQUID shares many properties with a superconducting coplanar stripline. We calculate magnetic-field and current-density profiles, the inductance (including both geometric and kinetic inductances), magnetic moments, and the effective area as a function of \Lambda/w and a/w.Comment: 18 pages, 20 figures, revised for Phys. Rev. B, the main revisions being to denote the effective flux by \Phi rather than

Superconducting thin rings with finite penetration depth

Recently Babaei Brojeny and Clem [Phys. Rev. B 68, 174514 (2003)] considered superconducting thin-film rings in perpendicular magnetic fields in the ideal Meissner state with negligibly small magnetic penetration depth and presented useful analytical limiting expressions and numerical results for the magnetic-field and sheet-current profiles, trapped magnetic flux, self-inductance, magnetic moment, and focusing of magnetic flux into the hole when no net current flows in the ring. The present paper generalizes all these results to rings with arbitrary values of the two-dimensional effective penetration depth \Lambda = \lambda^2 /d (\lambda is the London depth and d < \lambda/2 the film thickness) using a straightforward matrix inversion method. We also present results for the energy of a superconducting ring as a function of the applied magnetic induction B_a and the quantum number N defining the size of the fluxoid N \phi_0 trapped in the hole.Comment: with 19 figures, gives 11.5 page

Magnetic-field and current-density distributions in thin-film superconducting rings and disks

We show how to calculate the magnetic-field and sheet-current distributions for a thin-film superconducting annular ring (inner radius a, outer radius b, and thickness d<<a) when either the penetration depth obeys lambda < d/2 or, if lambda > d/2, the two-dimensional screening length obeys Lambda = 2 lambda^2/d << a for the following cases: (a) magnetic flux trapped in the hole in the absence of an applied magnetic field, (b) zero magnetic flux in the hole when the ring is subjected to an applied magnetic field, and (c) focusing of magnetic flux into the hole when a magnetic field is applied but no net current flows around the ring. We use a similar method to calculate the magnetic-field and sheet-current distributions and magnetization loops for a thin, bulk-pinning-free superconducting disk (radius b) containing a dome of magnetic flux of radius a when flux entry is impeded by a geometrical barrier.Comment: 10 pages, 13 figure

Atrial natriuretic peptide in heart failure

AbstractAtrial natriuretic peptide is a peptide hormone of cardiac origin, which is released in response to atrial distension and serves to maintain sodium homeostasis and inhibit activation of the reninangiotensin-aldosterone system. Congestive heart failure is a clinical syndrome characterized by increased cardiac volume and pressure overload with an inability to excrete a sodium load, which is associated with increased activity of systemic neurohumoral and local autocrine and paracrine mechanisms. Circulating atrial natriuretic peptide is greatly increased in congestive heart failure as a result of increased synthesis and release of this hormone. Atrial natriuretic peptide has emerged as an important diagnostic and prognostic serum marker in congestive heart failure. In early heart failure, it may play a key role in preserving the compensated state of asymptomatic left ventricular dysfunction. Despite increased circulating atrial natriuretic peptide in heart failure, the kidney retains sodium and is hyporesponsive to exogenous and endogenous atrial natriuretic peptide. The mechanism for the attenuated renal response is multifactorial and includes renal hypoperfusion, activation of the renin-angiotensin-aldosterone and sympathetic nervous systems. Therapeutic strategies to potentiate the biologic actions of atrial natriuretic peptide may prolong the asymptomatic phase and delay progression to overt congestive heart failure

Advances in Bayesian Time Series Modeling and the Study of Politics: Theory Testing, Forecasting, and Policy Analysis.&quot;

Bayesian approaches to the study of politics are increasingly popular. But Bayesian approaches to modeling multiple time series have not been critically evaluated. This is in spite of the potential value of these models in international relations, political economy, and other fields of our discipline. We review recent developments in Bayesian multi-equation time series modeling in theory testing, forecasting, and policy analysis. Methods for constructing Bayesian measures of uncertainty of impulse responses (Bayesian shape error bands) are explained. A reference prior for these models that has proven useful in short-and medium-term forecasting in macroeconomics is described. Once modified to incorporate our experience analyzing political data and our theories, this prior can enhance our ability to forecast over the short and medium terms complex political dynamics like those exhibited by certain international conflicts. In addition, we explain how contingent Bayesian forecasts can be constructed, contingent Bayesian forecasts that embody policy counterfactuals. The value of these new Bayesian methods is illustrated in a reanalysis of the Israeli-Palestinian conflict of the 1980s

Pharmacotherapy of vestibular and ocular motor disorders, including nystagmus

We review current pharmacological treatments for peripheral and central vestibular disorders, and ocular motor disorders that impair vision, especially pathological nystagmus. The prerequisites for successful pharmacotherapy of vertigo, dizziness, and abnormal eye movements are the “4 D’s”: correct diagnosis, correct drug, appropriate dosage, and sufficient duration. There are seven groups of drugs (the “7 A’s”) that can be used: antiemetics; anti-inflammatory, anti-Ménière’s, and anti-migrainous medications; anti-depressants, anti-convulsants, and aminopyridines. A recovery from acute vestibular neuritis can be promoted by treatment with oral corticosteroids. Betahistine may reduce the frequency of attacks of Ménière’s disease. The aminopyridines constitute a novel treatment approach for downbeat and upbeat nystagmus, as well as episodic ataxia type 2 (EA 2); these drugs may restore normal “pacemaker” activity to the Purkinje cells that govern vestibular and cerebellar nuclei. A limited number of trials indicate that baclofen improves periodic alternating nystagmus, and that gabapentin and memantine improve acquired pendular and infantile (congenital) nystagmus. Preliminary reports suggest suppression of square-wave saccadic intrusions by memantine, and ocular flutter by beta-blockers. Thus, although progress has been made in the treatment of vestibular neuritis, some forms of pathological nystagmus, and EA 2, controlled, masked trials are still needed to evaluate treatments for many vestibular and ocular motor disorders, including betahistine for Ménière’s disease, oxcarbazepine for vestibular paroxysmia, or metoprolol for vestibular migraine

Presence of C-type natriuretic peptide in human kidney and urine

Presence of C-type natriuretic peptide in human kidney and urine. The current study was undertaken to investigate the presence of CNP immunoreactivity in both human kidney and urine. Immunohistochemical staining with an indirect immunoperoxidase method utilizing an antibody which is 100% cross-reactive to both CNP-53 and CNP-22 was performed on five human kidney specimens (three biopsies of normal cadaveric donor kidneys and two of normal autopsy specimens). CNP immunoreactivity was positive in proximal, distal and medullary collecting duct tubular cells in a cytoplasmic and granular staining pattern. CNP immunoreactivity was also determined in the urine of five healthy volunteers utilizing a sensitive and specific double-antibody radioimmunoassay with a mean concentration of 10.8 ± 1.0 pg/ml. With the utilization of high pressure liquid chromatography, this immunoreactivity proved to be consistent with both the low molecular weight form, CNP-22, as well as the high molecular weight form, CNP-53. Urinary excretion of CNP was also measured in normal subjects (N = 5) and in patients with congestive heart failure (CHF, N = 6). CHF patients excreted over three times more CNP than normals (27.2 ± 2.8 vs. 8.7 ± 0.81 pg/min, P < 0.004) despite no difference between the two groups in plasma CNP concentrations (6.97 ± 0.28 vs. 8.08 ± 1.52 pg/ml, P = NS). This study demonstrates for the first time the presence of CNP immunoreactivity in human kidney and suggests that renal tubular cells may be an additional non-vascular site of synthesis for this cardiorenal acting peptide. This study also demonstrates an increase in urinary CNP excretion in congestive heart failure

Pennsylvania’s True Commonwealth: The State of Manufacturing – Challenges and Opportunities (Full Report)

The Industrial Resource Center Network of Pennsylvania is the state’s affiliate of the National Institute of Standards and Technology’s Hollings Manufacturing Extension Partnership program. Both the IRC program and the MEP have longstanding traditions of self-assessment and evolution as ways of being accountable to the public and of promoting continuous improvement. The IRC program and the MEP are charged with helping manufacturing in general, and small to midsized manufacturers in particular, improve their competitive position. The IRC program uses the outcomes from these assessments to think about the challenges their constituents face due to rapid evolution in the globally competitive environment. Additionally, the IRC Program has joined with the MEP to discover best management and production practices, standardize them in terms of educational and training practices, and then disseminate these practices widely. Again, this is with an emphasis on small and midsized establishments and businesses. This report builds on the 2004 report, Manufacturing Pennsylvania’s Future, written by Deloitte Consulting and the Maxine Goodman Levin College of Urban Affairs at Cleveland State University. In August 2010, as the negative impact of the Great Recession was beginning to ebb and after a decade of global competitive challenges, the IRC Program embarked on a new round of self-evaluation and assessment. The economic development and nonprofit management research groups at Cleveland State University’s Levin College were engaged to examine the state of manufacturing in the Commonwealth, discover the management practices of the “best of the best” manufacturers in the state, and suggest practice innovations that would enhance the competitive position of Pennsylvania’s manufacturers. This work was undertaken with the MPI Group. The project was supported by funding from the Industrial Resource Center program, the Hollings Manufacturing Extension Partnership of the National Institute of Standards and Technology, the John D.and Catherine T. MacArthur Foundation’s Network on Building Resilient Regions, and the Pennsylvania Department of Community and Economic Development, with funding provided by the National Telecommunications and Information Administration. The work benefited from the advice and review of an external advisory board that was facilitated by Ken Voytek, NIST/MEP’s chief economist, and Joe Houldin, CEO of the Delaware Valley Industrial Resource Center. They worked with: Emily DeRocco, President, the Manufacturing Institute of the National Association of Manufacturers; Samuel Leiken, Vice President of the Council on Competitiveness; Howard Wial, Ph.D., Fellow of the Metropolitan Policy Program of the Brookings Institution; and Mike Trebing, Senior Economic Analyst, Federal Reserve Bank of Philadelphia. The work was also reviewed and discussed by the IRC’s Strategic Advisory Board and the directors of the network\u27s seven centers. The report also benefited from data provided by the Central Pennsylvania Workforce Development Corporation (CPWDC). The research team acknowledges the many contributions of our advisers and funders. Their participation and support do not mean that each agrees with all we have written. The team alone is responsible for the findings and interpretation of the data