2008 official positions of the Brazilian Society for Clinical Densitometry - SBDens

With the evolution of bone densitometry, differences in technologies, acquisition techniques, reference databases, reporting methods, diagnostic criteria and terminology have developed and the International Society for Clinical Densitometry (ISCD) periodically holds Position Development Conferences, the latest in 2007. The Brazilian Society for Clinical Densitometry (SBDens), with support from many Brazilian societies interested in bone health, gathered numerous specialists to discuss the ISCD proposals and to evaluate the validity of the extension of those norms to Brazilian population. The SBDens reunion of consensus made a very utile document to help the understanding and interpretation of bone densitometry and other methods of bone assessment.A evolução dos métodos de avaliação da massa óssea trouxe diferentes tecnologias, modos de aquisição de imagens, bancos de dados de referência, terminologias, critérios diagnósticos fez com que a International Society for Bone Densitometry (ISCD) tomasse a iniciativa de promover reuniões periódicas de consenso, a última em 2007. A Sociedade Brasileira de Densitometria Clínica (SBDens), com apoio de várias sociedades brasileiras ligadas ao estudo da saúde óssea, reuniu diversos especialistas para discutir as propostas da ISCD e validar a aplicação destas normas à população brasileira. A reunião de Posições Oficiais da SBDens produziu um documento extremamente útil para a compreensão e interpretação da densitometria e de outros métodos de avaliação da massa óssea.Sociedade Brasileira de Densitometria ClínicaSociedade Brasileira para o Estudo do Metabolismo Ósseo e MineralUniversidade Federal de São Paulo (UNIFESP)Universidade Federal de Minas Gerais Hospital Mater DeiSociedade Brasileira de ReumatologiaSociedade Brasileira de OsteoporoseUniversidade de São Paulo Faculdade de Medicina Hospital das ClínicasAssociação Brasileira de Medicina Física e ReabilitaçãoUniversidade Federal do Espírito SantoUNIFESPColégio Brasileiro de RadiologiaSociedade Brasileira de Ortopedia e TraumatologiaUNIFESPSciEL

Contribuição ao estudo das formas circulantes do paratormônio

BV UNIFESP: Teses e dissertaçõe

Evaluation of bone mineral density during pubert in normal children in São Paulo: influence of anthropometric factors, body composition and SDHEA in ossea mass

BV UNIFESP: Teses e dissertaçõe

Letter to the Editor: Comment on Gaspar AP, Brandao CM, Lazaretti-Castro M. Bone mass and hormone analysis in spinal cord injury patients: evidences for a gonadal axis disruption Response

Universidade Federal de São Paulo, Escola Paulista Med, Div Endocrinol, BR-04021 São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Div Endocrinol, BR-04021 São Paulo, BrazilWeb of Scienc

PARATHYROID-HORMONE SECRETORY RESERVE IN PATIENTS SUBMITTED TO 131-IODINE THERAPY FOR HYPERTHYROIDISM

Twelve euthyroid patients who had been treated with I-131 for hyperthyroidism due to Graves' disease and six normal controls were submitted to an EDTA infusion test. Ionized calcium and parathyroid hormone were measured in serum samples collected every 10 min during the 2-h test. Basal values for calcium (1.22 +/- 0.03 vs 1.23 +/- 0.03 pmol/l, mean +/- SD, controls vs patients) and parathyroid hormone (3.3 +/- 0.65 vs 5.1 +/- 2.32 pmol/l) as well as maximum response during infusion (1.01 +/- 0.04 vs 1.01 +/- 0.05 for calcium and 12.0 +/- 2.2 vs 13.1 +/- 3.7 for parathyroid hormone) were not significantly different. We conclude that I-131 treatment for hyperthyroidism due to Graves' disease had no effect on the parathyroid gland secretory reserve of the patients studied.ESCOLA PAULISTA MED SCH,DISCIPLINA ENDOCRINOL,CAIXA POSTAL 20266,BR-04619 SAO PAULO,SP,BRAZILESCOLA PAULISTA MED SCH,DISCIPLINA ENDOCRINOL,CAIXA POSTAL 20266,BR-04619 SAO PAULO,SP,BRAZILWeb of Scienc

Serum leptin concentration during puberty in healthy nonobese adolescents

Data obtained during the past five years have indicated that there are important age- and gender-based differences in the regulation and action of leptin in humans. To study the physiological changes of leptin during puberty in both sexes, and its relationship with body composition and sexual maturation, we measured leptin concentrations in 175 healthy adolescents (80 girls, 95 boys, 10-18 years of age), representing all pubertal stages. We excluded individuals with a body mass index (BMI) below the 5thor above the 95th percentile relative to age. Serum concentrations of leptin were determined by a monoclonal antibody-based immunofluorimetric assay, developed in our laboratory. Body composition was determined by dual-energy X-ray absorptiometry. Pubertal stage was assigned by physical examination, according to Tanner criteria for breast development in females and genital development in males. Leptin concentration in girls (N = 80) presented a positive linear correlation with age (r = 0.35, P = 0.0012), BMI (r = 0.65, P < 0.0001) and %fat mass (r = 0.76, P < 0.0001). In boys (N = 95) there was a positive correlation with BMI (r = 0.49, P < 0.0001) and %fat mass (r = 0.85, P < 0.0001), but a significant negative linear correlation with Tanner stage (r = -0.45, P < 0.0001) and age (r = -0.40, P < 0.0001). The regression equation revealed that %fat mass and BMI are the best parameters to be used to estimate leptin levels in both sexes. Thus, the normal reference ranges for circulating leptin during adolescence should be constructed according to BMI or %fat mass to assure a correct evaluation

Persistent hyperactivity of the parathyroid glands in treated hypothyroid patients

Twelve untreated hypothyroid patients were submitted to EDTA infusion and the parathyroid hormone response to the induced hypocalcemia was studied with an amino-terminal specific assay. Eight of these patients were retested 6 months after achieving clinical and laboratory euthyroidism. The PTH response in the pretreatment condition was significantly higher than that obtained in a group of 10 normal individuals; this increased response had not normalized after 6 months of euthyroidism. This persisting hyperresponsiveness can be a contributory factor to the bone hypersensitivity to thyroid hormone replacement seen in hypothyroid patients.ESCOLA PAULISTA MED SCH,DIV ENDOCRINOL,CP 20266,BR-04034 SAO PAULO,BRAZILESCOLA PAULISTA MED SCH,DIV ENDOCRINOL,CP 20266,BR-04034 SAO PAULO,BRAZILWeb of Scienc