794 research outputs found
Territorial development, planning reform and urban governance: the case of Ireland's second-tier cities
The increased emphasis within Europe on the role of second-tier cities has implications for the ways in which these urban centres are considered within national spatial planning strategies. In centralised, monocentric states like Ireland, there has been a general ambivalence towards urban policy for cities outside the capital city, and historically this has prevented the development of a strong, diversified urban hierarchy undermining prospects for balanced regional development. This paper examines the extent to which a new found emphasis on Ireland’s second-tier cities which emerged in the ‘Gateways’ policy of the National Spatial Strategy (NSS, 2002) was matched by subsequent political and administrative commitment to facilitate the development of these urban centres. Following a discussion of the position of second-tier cities in an international context and a brief overview of recent demographic and economic trends, the paper assesses the relative performance of Ireland’s second-tier cities in influencing development trends, highlighting a comprehensive failure to deliver compact urban growth. In this context, the paper then discusses the implications of current development plans for the second-tier cities and proposals for Irish local government reform for securing compact urban development
Essays in strategic spatial planning and governance in Ireland’s city – regions
The aim of this PhD project is to develop an understanding of how strategic spatial planning is expressed and delivered as a specific mode of governance, in response to the particular challenges facing Europe’s second-tier cities. It is concerned with how planning, as a particular form of public policy and a form of governance-in-action, materialises at certain spatial scales and how it is influencing patterns of territorial development. In addition, the research interrogates the ways in which planning practice applies its basic principles through planning policy, decision making, and by exploring the normative basis of the profession’s activities. The connecting theme relates to an interest in how planning is governed, how it is expressed as a specific mode of governance in urban settings and how decision-making around planning projects navigates through a variety of social, political and economic filters. These phenomena are explored in this thesis using a series of thematic empirical pieces, which relate broadly to the field of strategic spatial planning at city-region/metropolitan level. The PhD is presented as a series of discrete articles, submitted under University regulations as a publication-based thesis. These essays are concerned primarily with developing insights into the nature of contemporary strategic spatial planning and place-making as a mode of governance. The empirical work, which uses episodes of strategic spatial planning in Ireland and Cork as a master case study framework, addresses four core themes. Firstly, it confronts the issue of central-local dynamics as part of strategic spatial planning at the national scale, using the experiences of Ireland’s second-tier cities as part of the national spatial planning agenda. Secondly, it is concerned with understanding how strategic spatial planning frames policy and practice for metropolitan areas and the way in which it operates as a framework for articulating urban governance strategies. The third theme explores the transformative capacity of strategic spatial planning as an instrument for the promotion of sustainable development practices. The fourth theme addresses methodological concerns around the particular challenges associated with scholarly inquiry within the realm of strategic spatial planning. The thesis outlines four sets of main findings relating to the core themes, which in different ways characterise the nature of change in strategic spatial planning in Ireland. First, there has been an important shift towards place-based approaches under Ireland’s national planning regime, whereby the city/metropolitan region emerges as a spatial unit with the potential to integrate a variety of spatial and sectoral policy strands. This however has not created new territorial governance patterns or a rescaling of power within the state and around city-regions. Although the case of Cork presents a case whereby strategic spatial planning has emerged as a clearly recognisable form of territorial management with distinctive governance dimensions, this proves to be an exceptional case. The move towards placed-based spatial strategies in Ireland has been limited to new frames of reference rather than new forms of governance, and place-based spatial strategies largely emerged within the soft spaces of governance. The research has established an absence of clarity about governance needs at the city-region and metropolitan scales, particularly at the second-tier city level. Second, the analysis of these episodes of spatial planning illustrates the dynamic nature of governance as part of a rapidly evolving economic and social global order, which is characterised by flexibility, speed and innovation. Conversely, these episodes also illustrate the stability of established institutional and administrative structures and norms, and a degree of resistance to those emerging governance changes - particularly those expressed at the regional and metropolitan scales. In the absence of strong sub-regional or metropolitan governance structures, the rollout of spatial strategies at this scale in Ireland’s second-tier cities was generally fragmentary and the kind of unified territorial, placed-based approach advocated in the National Spatial Strategy (NSS) never materialised. However, Cork exists as a particular exception in this regard; its experiences reflect a restructuring and rescaling of planning at metropolitan and sub-regional levels, where a mix of top-down and bottom-up forces are combining to produce a semi-formalised, nonstatutory planning regime. Third, the analysis of the post- NSS landscape in Ireland demonstrates clearly the limitations of strategic spatial planning as a transformative framework, with evidence of a divergence of economic and settlement patterns - with long-term sustainability implications. Recent experiences in Ireland’s key gateway cities would suggest that although the ‘soft spaces of governance’ are a necessary feature of the urban decision-making landscape, they are not conducive to making hard decisions. However, the kinds of strategic planning initiatives deployed in Cork certainly resonate with the concept of transformative practice as outlined in the planning literature. The rail strategy, for example, can be interpreted as an attempt to transform completely the economic and environmental trajectory of development in the city-region, using a series of arguments around environmental and social quality based on what can be considered a grand place-making concept. However, such projects are unlikely to acquire socio-spatial transformative characteristics unless established modes of governance are moderated and if public policy considers more actively the political-institutional landscape in which these efforts are situated. Fourth, in the examination of national and sub-regional episodes of strategic spatial planning in Ireland, which evolved over the course of the four essays, it was necessary to adapt and extend the methodological framework. This involved extending the empirical investigations beyond the confines of an instrumentalist perspective, and engaging in a more comprehensive analysis of governance narratives. The research also relied on a mixed conformance-performance analytical mode of inquiry, based on the ‘Dutch model’ of planning assessment. Because of the complex and stratified research terrain, the analysis combined an instrumentalist conformance-based analysis with an assessment of its performance as mode of strategic spatial planning in practice. The evolution of analysis during the research process would suggest that a full understanding of the operation and impact of strategic spatial planning projects cannot be conducted without combining an assessment of both conformance and performance. In conclusion, the case of strategic spatial planning in Ireland and in Cork demonstrates the ways in which strategic spatial planning has penetrated policy and practice discourses, and has served to deliver a comprehensive transformation in planning as a discipline and within the broader arena of public policy. Overall, we can see a remarkable consistency in how planning episodes articulate their basic premise, which relates to an enduring focus on the arrangement of development in territories and with the idea of spatial order. Although there has been a general reluctance to institutionalise planning units like city-regions or metropolitan areas as formal government entities, they are being deployed increasingly as containers for strategic spatial planning. The research has also indicated that long term, coherent strategic spatial planning across administrative boundaries, based on consistent ideas about governing/planning spaces, can produce what may be understood as a metropolitan consciousness. This may be understood as a tacit project around an informal spatial construct, which, over time, gains legitimacy as a strong governance space (in which decisions are brokered) and as a metaphor (for articulating a collective vision for the urban area’s long-term future). Strategic spatial planning also involves dealing with complexity, and as a result, deploys methods that encourage what may be termed spatial-thematic selectivity. This can be translated as the prioritisation of a limited number of high profile interventions that are spatially and sectorally integrative – manifesting in large-scale, geographically expansive and symbolic projects that are designed to reorient territorial trajectories and produce symbolic-political support across broad coalitions. The research would also suggest that in Ireland’s post-economic crisis period, and in a broader neoliberal political setting in which the state appears to have shirked its responsibility for managing and sponsoring urban affairs, we see the emergence of strategic spatial planning as a proxy for urban governance. As formal urban governing competencies are reduced as part of a clear centralisation agenda, and with city-regions assuming greater economic responsibilities, strategic spatial planning becomes an arena in which urban governance capacity is exercised. Consequently, strategic and fundamental decisions about urban development, infrastructure programmes and public investment are increasingly considered within the realm of strategic spatial planning – which performs as a substitute for traditional urban government, and in turn, as a proxy for urban governance
Integrated inertial stellar attitude sensor
An integrated inertial stellar attitude sensor for an aerospace vehicle includes a star camera system, a gyroscope system, a controller system for synchronously integrating an output of said star camera system and an output of said gyroscope system into a stream of data, and a flight computer responsive to said stream of data for determining from the star camera system output and the gyroscope system output the attitude of the aerospace vehicle
1084-176 Efficacy of ezetimibe coadministered with simvastatin versus atorvastatin in patients with hypercholesterolemia
Coiled coils 9-to-5:rational de novo design of α-helical barrels with tunable oligomeric states
Radiative falloff in Schwarzschild-de Sitter spacetime
We consider the time evolution of a scalar field propagating in
Schwarzschild-de Sitter spacetime. At early times, the field behaves as if it
were in pure Schwarzschild spacetime; the structure of spacetime far from the
black hole has no influence on the evolution. In this early epoch, the field's
initial outburst is followed by quasi-normal oscillations, and then by an
inverse power-law decay. At intermediate times, the power-law behavior gives
way to a faster, exponential decay. At late times, the field behaves as if it
were in pure de Sitter spacetime; the structure of spacetime near the black
hole no longer influences the evolution in a significant way. In this late
epoch, the field's behavior depends on the value of the curvature-coupling
constant xi. If xi is less than a critical value 3/16, the field decays
exponentially, with a decay constant that increases with increasing xi. If xi >
3/16, the field oscillates with a frequency that increases with increasing xi;
the amplitude of the field still decays exponentially, but the decay constant
is independent of xi.Comment: 10 pages, ReVTeX, 5 figures, references updated, and new section
adde
Selected Toll-like Receptor Ligands and Viruses Promote Helper-Independent Cytotoxic T Cell Priming by Upregulating CD40L on Dendritic Cells
SummaryCD40L (CD154) on CD4+ T cells has been shown to license dendritic cells (DCs) via CD40 to prime cytotoxic T lymphocyte (CTL) responses. We found that the converse (CD40L on DCs) was also important. Anti-CD40L treatment decreased endogenous CTL responses to both ovalbumin and influenza infection even in the absence of CD4+ T cells. DCs expressed CD40L upon stimulation with agonists to Toll-like receptor 3 (TLR3) and TLR9. Moreover, influenza infection, which stimulates CTLs without help, upregulated CD40L on DCs, but herpes simplex infection, which elicits CTLs through help, did not. CD40L-deficient (Cd40lg−/−) DCs are suboptimal both in vivo in bone marrow chimera experiments and in vitro in mixed lymphocyte reactions. In contrast, Cd40lg−/− CD8+ T cells killed as effectively as wild-type cells. Thus, CD40L upregulation on DCs promoted optimal priming of CD8+ T cells without CD4+ T cells, providing a mechanism by which pathogens may elicit helper-independent CTL immunity
Genome-wide linkage using the Social Responsiveness Scale in Utah autism pedigrees
<p>Abstract</p> <p>Background</p> <p>Autism Spectrum Disorder<b>s </b>(ASD) are phenotypically heterogeneous, characterized by impairments in the development of communication and social behaviour and the presence of repetitive behaviour and restricted interests. Dissecting the genetic complexity of ASD may require phenotypic data reflecting more detail than is offered by a categorical clinical diagnosis. Such data are available from the Social Responsiveness Scale (SRS) which is a continuous, quantitative measure of social ability giving scores that range from significant impairment to above average ability.</p> <p>Methods</p> <p>We present genome-wide results for 64 multiplex and extended families ranging from two to nine generations. SRS scores were available from 518 genotyped pedigree subjects, including affected and unaffected relatives. Genotypes from the Illumina 6 k single nucleotide polymorphism panel were provided by the Center for Inherited Disease Research. Quantitative and qualitative analyses were done using MCLINK, a software package that uses Markov chain Monte Carlo (MCMC) methods to perform multilocus linkage analysis on large extended pedigrees.</p> <p>Results</p> <p>When analysed as a qualitative trait, linkage occurred in the same locations as in our previous affected-only genome scan of these families, with findings on chromosomes 7q31.1-q32.3 [heterogeneity logarithm of the odds (HLOD) = 2.91], 15q13.3 (HLOD = 3.64), and 13q12.3 (HLOD = 2.23). Additional positive qualitative results were seen on chromosomes 6 and 10 in regions that may be of interest for other neuropsychiatric disorders. When analysed as a quantitative trait, results replicated a peak found in an independent sample using quantitative SRS scores on chromosome 11p15.1-p15.4 (HLOD = 2.77). Additional positive quantitative results were seen on chromosomes 7, 9, and 19.</p> <p>Conclusions</p> <p>The SRS linkage peaks reported here substantially overlap with peaks found in our previous affected-only genome scan of clinical diagnosis. In addition, we replicated a previous SRS peak in an independent sample. These results suggest the SRS is a robust and useful phenotype measure for genetic linkage studies of ASD. Finally, analyses of SRS scores revealed linkage peaks overlapping with evidence from other studies of neuropsychiatric diseases. The information available from the SRS itself may, therefore, reveal locations for autism susceptibility genes that would not otherwise be detected.</p
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