Physical and social access to land: Spatio-temporal patterns of agricultural expansion

Abstract The expansion of agriculture is posited as one of the main dynamics of land cover change globally, and the robust modeling of these processes is important for policy as well as academic concerns. Madagascar's farmers stand accused as the "proximate agents" of land conversion in one of the world's "hottest" biodiversity hotspots, and numerous studies have been conducted to describe and model the processes by which the country's forests are giving way to agriculture. This paper concerns a relatively small area on the island's eastern escarpment where considerable national and international attention has been paid to slow the expansion of agriculture into the remaining natural forests. The approach adopted here is to begin by examining the degree to which patterns of agricultural conversion can be attributed to a set of factors that have been identified as significant at broader scales in Madagascar and elsewhere, namely topography and prior human settlement and land use patterns. A regression model is constructed, and its predictions compared to the observed land conversion over a 43-year period. The study then examines in detail the spatial patterns highlighted by the failure of the model (the residuals of the regression), breaking the study area into smaller zones, or landscapes. The spatio-temporal trajectories of these zones are then contrasted, with particular attention to the institutional arrangements governing access to land resources. The study finds that while overall land change patterns in the region are largely explained by elevation and village proximity, more specific, sub-regional, trajectories reflect the signatures of institutions governing access to land

Rapid Depletion of Target Proteins Allows Identification of Coincident Physiological Responses

Targeted protein degradation is a powerful tool that can be used to create unique physiologies depleted of important factors. Current strategies involve modifying a gene of interest such that a degradation peptide is added to an expressed target protein and then conditionally activating proteolysis, either by expressing adapters, unmasking cryptic recognition determinants, or regulating protease affinities using small molecules. For each target, substantial optimization may be required to achieve a practical depletion, in that the target remains present at a normal level prior to induction and is then rapidly depleted to levels low enough to manifest a physiological response. Here, we describe a simplified targeted degradation system that rapidly depletes targets and that can be applied to a wide variety of proteins without optimizing target protease affinities. The depletion of the target is rapid enough that a primary physiological response manifests that is related to the function of the target. Using ribosomal protein Si as an example, we show that the rapid depletion of this essential translation factor invokes concomitant changes to the levels of several mRNAs, even before appreciable cell division has occurred

A millimeter-wave kinetic inductance detector camera for long-range imaging through optical obscurants

Millimeter-wave imaging provides a promising option for long-range target detection through optical obscurants such as fog, which often occur in marine environments. Given this motivation, we are currently developing a 150 GHz polarization-sensitive imager using a relatively new type of superconducting pair-breaking detector, the kinetic inductance detector (KID). This imager will be paired with a 1.5 m telescope to obtain an angular resolution of 0.09° over a 3.5° field of view using 3,840 KIDs. We have fully characterized a prototype KID array, which shows excellent performance with noise strongly limited by the irreducible fluctuations from the ambient temperature background. Full-scale KID arrays are now being fabricated and characterized for a planned demonstration in a maritime environment later this year

WHOI Hawaii Ocean Timeseries Station (WHOTS) : WHOTS-3 mooring turnaround cruise report

The Woods Hole Oceanographic Institution (WHOI) Hawaii Ocean Timeseries (HOT) Site (WHOTS), 100 km north of Oahu, Hawaii, is intended to provide long-term, high-quality air-sea fluxes as a coordinated part of the HOT program and contribute to the goals of observing heat, fresh water, and chemical fluxes at a site representative of the oligotrophic North Pacific Ocean. The approach is to maintain a surface mooring outfitted for meteorological and oceanographic measurements at a site near 22.75N 158W by successive mooring turnarounds. These observations will be used to investigate air-sea interaction processes related to climate variability. The first WHOTS mooring (WHOTS-1) was deployed in August 2004. WHOTS-1 was recovered and WHOTS-2 deployed in July 2005. This report documents recovery of the WHOTS-2 mooring and deployment of the third mooring (WHOTS-3) at the same site. Both moorings used Surlyn foam buoys as the surface element and were outfitted with two Air-Sea Interaction Meteorology (ASIMET) systems. Each system measures, records, and transmits via Argos satellite, the surface meteorological variables necessary to compute air-sea fluxes of heat, moisture, and momentum. WHOTS-2 was equipped with one Iridium data transmitter, and WHOTS-3 had two Iridium data transmitters. In cooperation with R. Lukas of the University of Hawaii, the upper 155 m of the morrings were outfitted with oceanographic sensors for the measurement of temperature, conductivity, and velocity. The WHOTS mooring turnaround was done on the Scripps Institution of Oceanography ship Revelle, Cruise AMAT-07, by the Upper Ocean Processes Group of the Woods Hole Oceanographic Institution and Roger Lukas’group at the University of Hawaii. The cruise took place between 22 and 29 June 2006. Operations on site were initiated with an intercomparison of shipboard meteorological observations with the WHOTS-2 buoy. Dr. Frank Bradley, CSIRO, Australia, assisted with these comparisons. This was followed by recovery of the WHOTS-2 mooring on 24 June. A number of recovered instruments were calibrated by attaching them to the rosette frame of the CTD. Shallow CTD profiles were taken every two hours for 12 hours on the 25th of June. A fish trap was deployed on June 25th by John Yeh, a University of Hawaii graduate student. The WHOTS-3 mooring was deployed on 26 June at approximately 22°46'N, 157°54'W in 4703 m of water. A ship-buoy intercomparison period and series of shallow CTDs followed along with a second deployment of the fishtrap. A NOAA Teacher-At-Sea, Diana Griffiths, and a NOAA Hollings Scholar, Terry Smith, participated in the cruise. This report describes the mooring operations, some of the pre-cruise buoy preparations and CTD casts taken during the cruise, the fish trap deployments, and the experiences of the Teacher-at-Sea and Hollings Scholar.Funding was provided by the National Oceanic and Atmospheric Administration under grant No. NA17RJ1223 for the Cooperative Institute for Climate and Ocean Research (CICOR)

Stratus Ocean Reference Station (20˚S, 85˚W) mooring recovery and deployment cruise STRATUS 8 R/V Ronald H. Brown cruise 07-09 October 9, 2007–November 6, 2007

The Ocean Reference Station at 20°S, 85°W under the stratus clouds west of northern Chile is being maintained to provide ongoing climate-quality records of surface meteorology (air-sea fluxes of heat, freshwater, and momentum), and of upper ocean temperature, salinity, and velocity variability. The Stratus Ocean Reference Station (ORS Stratus) is supported by the National Oceanic and Atmospheric Administration’s (NOAA) Climate Observation Program. It is recovered and redeployed annually, with cruises between October and December. During the October 2007 cruise on the NOAA ship Ronald H. Brown to the ORS Stratus site, the primary activities were recovery of the Stratus 7 WHOI surface mooring that had been deployed in October 2006, deployment of a new (Stratus 8) WHOI surface mooring at that site; in-situ calibration of the buoy meteorological sensors by comparison with instrumentation put on board the ship by staff of the NOAA Earth System Research Laboratory (ESRL); and observations of the stratus clouds and lower atmosphere by NOAA ESRL. Meteorological sensors on a buoy for the Pacific tsunami warning system were also serviced, in collaboration with the Hydrographic and Oceanographic Service of the Chilean Navy (SHOA). The DART (Deep-Ocean Assessment and Reporting of Tsunami) carries IMET sensors and subsurface oceanographic instruments. A new DART II buoy was deployed north of the STRATUS buoy, by personnel from the National Data Buoy Center (NDBC) Argo floats and drifters were launched, and CTD casts carried out during the cruise. The ORS Stratus buoys are equipped with two Improved Meteorological (IMET) systems, which provide surface wind speed and direction, air temperature, relative humidity, barometric pressure, incoming shortwave radiation, incoming longwave radiation, precipitation rate, and sea surface temperature. Additionally, the Stratus 8 buoy received a partial pressure of CO2 detector from the Pacific Marine Environmental Laboratory (PMEL). IMET data are made available in near real time using satellite telemetry. The mooring line carries instruments to measure ocean salinity, temperature, and currents. The ESRL instrumentation used during the 2007 cruise included cloud radar, radiosonde balloons, and sensors for mean and turbulent surface meteorology. Finally, the cruise hosted a teacher participating in NOAA’s Teacher at Sea Program.Funding was provided by the National Oceanic and Atmospheric Administration under Grant No. NA17RJ1223 for the Cooperative Institute for Climate and Ocean Research (CICOR)

The American Association for the Surgery of Trauma renal injury grading scale: Implications of the 2018 revisions for injury reclassification and predicting bleeding interventions.

BackgroundIn 2018, the American Association for the Surgery of Trauma (AAST) published revisions to the renal injury grading system to reflect the increased reliance on computed tomography scans and non-operative management of high-grade renal trauma (HGRT). We aimed to evaluate how these revisions will change the grading of HGRT and if it outperforms the original 1989 grading in predicting bleeding control interventions.MethodsData on HGRT were collected from 14 Level-1 trauma centers from 2014 to 2017. Patients with initial computed tomography scans were included. Two radiologists reviewed the scans to regrade the injuries according to the 1989 and 2018 AAST grading systems. Descriptive statistics were used to assess grade reclassifications. Mixed-effect multivariable logistic regression was used to measure the predictive ability of each grading system. The areas under the curves were compared.ResultsOf the 322 injuries included, 27.0% were upgraded, 3.4% were downgraded, and 69.5% remained unchanged. Of the injuries graded as III or lower using the 1989 AAST, 33.5% were upgraded to grade IV using the 2018 AAST. Of the grade V injuries, 58.8% were downgraded using the 2018 AAST. There was no statistically significant difference in the overall areas under the curves between the 2018 and 1989 AAST grading system for predicting bleeding interventions (0.72 vs. 0.68, p = 0.34).ConclusionAbout one third of the injuries previously classified as grade III will be upgraded to grade IV using the 2018 AAST, which adds to the heterogeneity of grade IV injuries. Although the 2018 AAST grading provides more anatomic details on injury patterns and includes important radiologic findings, it did not outperform the 1989 AAST grading in predicting bleeding interventions.Level of evidencePrognostic and Epidemiological Study, level III

Exercise, APOE, and Working Memory: MEG and Behavioral Evidence for Benefit of Exercise in Epsilon4 Carriers

Performance on the Sternberg working memory task, and MEG cortical response on a variation of the Sternberg task were examined in middle-aged carriers and non-carriers of the APOE ε4 allele. Physical activity was also assessed to examine whether exercise level modifies the relationship between APOE genotype and neurocognitive function. Regression revealed that high physical activity was associated with faster RT in the six- and eight-letter conditions of the Sternberg in ε4 carriers, but not in the non-carriers after controlling for age, gender, and education (N = 54). Furthermore, the MEG analysis revealed that sedentary ε4 carriers exhibited lower right temporal lobe activation on matching probe trials relative to high-active ε4 carriers, while physical activity did not distinguish non-carriers (N = 23). The M170 peak was identified as a potential marker for pre-clinical decline as ε4 carriers exhibited longer M170 latency, and highly physically active participants exhibited greater M170 amplitude to matching probe trials

Spot the difference: Comparing results of analyses from real patient data and synthetic derivatives

BACKGROUND: Synthetic data may provide a solution to researchers who wish to generate and share data in support of precision healthcare. Recent advances in data synthesis enable the creation and analysis of synthetic derivatives as if they were the original data; this process has significant advantages over data deidentification. OBJECTIVES: To assess a big-data platform with data-synthesizing capabilities (MDClone Ltd., Beer Sheva, Israel) for its ability to produce data that can be used for research purposes while obviating privacy and confidentiality concerns. METHODS: We explored three use cases and tested the robustness of synthetic data by comparing the results of analyses using synthetic derivatives to analyses using the original data using traditional statistics, machine learning approaches, and spatial representations of the data. We designed these use cases with the purpose of conducting analyses at the observation level (Use Case 1), patient cohorts (Use Case 2), and population-level data (Use Case 3). RESULTS: For each use case, the results of the analyses were sufficiently statistically similar ( DISCUSSION AND CONCLUSION: This article presents the results of each use case and outlines key considerations for the use of synthetic data, examining their role in clinical research for faster insights and improved data sharing in support of precision healthcare