191 research outputs found
CLT-38 Enabling effective public involvement: a case study of involvement in the HighCALS research programme
The Mathematical Universe
I explore physics implications of the External Reality Hypothesis (ERH) that
there exists an external physical reality completely independent of us humans.
I argue that with a sufficiently broad definition of mathematics, it implies
the Mathematical Universe Hypothesis (MUH) that our physical world is an
abstract mathematical structure. I discuss various implications of the ERH and
MUH, ranging from standard physics topics like symmetries, irreducible
representations, units, free parameters, randomness and initial conditions to
broader issues like consciousness, parallel universes and Godel incompleteness.
I hypothesize that only computable and decidable (in Godel's sense) structures
exist, which alleviates the cosmological measure problem and help explain why
our physical laws appear so simple. I also comment on the intimate relation
between mathematical structures, computations, simulations and physical
systems.Comment: Replaced to match accepted Found. Phys. version, 31 pages, 5 figs;
more details at http://space.mit.edu/home/tegmark/toe.htm
Localization and symmetries
The violation of the Noether relation between symmetries and charges is
reduced to the time dependence of the charge associated to a conserved current.
For the U(1) gauge symmetry a non-perturbative control of the charge
commutators is obtained by an analysis of the Coulomb charged fields. From
this, in the unbroken case we obtain a correct expression for the electric
charge on the Coulomb states, its superselection and the presence of massless
vector bosons; in the broken case, we obtain a general non-perturbative version
of the Higgs phenomenon, i.e. the absence of massless Goldstone bosons and of
massless vector bosons. The conservation of the (gauge dependent) current
associated to the U(1) axial symmetry in QCD is shown to be compatible with the
time dependence of the corresponding charge commutators and a non-vanishing
eta' mass, as a consequence of the non locality of the (conserved) current.Comment: Invited contribution to ``The Quantum Universe'', dedicated to G.
Ghirardi for his 70th birthda
The effect of alpha-blocker treatment on bladder hypoxia inducible factor-1 alpha regulation during lower urinary tract obstruction
Reflections on the four facets of symmetry: how physics exemplifies rational thinking
In contemporary theoretical physics, the powerful notion of symmetry stands
for a web of intricate meanings among which I identify four clusters associated
with the notion of transformation, comprehension, invariance and projection.
While their interrelations are examined closely, these four facets of symmetry
are scrutinised one after the other in great detail. This decomposition allows
us to examine closely the multiple different roles symmetry plays in many
places in physics. Furthermore, some connections with others disciplines like
neurobiology, epistemology, cognitive sciences and, not least, philosophy are
proposed in an attempt to show that symmetry can be an organising principle
also in these fields
Protein kinase C modulates frequency of micturition and non-voiding contractions in the urinary bladder via neuronal and myogenic mechanisms
New broad-spectrum resistance to septoria tritici blotch derived from synthetic hexaploid wheat
Septoria tritici blotch (STB), caused by the ascomycete Mycosphaerella graminicola, is one of the most devastating foliar diseases of wheat. We screened five synthetic hexaploid wheats (SHs), 13 wheat varieties that represent the differential set of cultivars and two susceptible checks with a global set of 20 isolates and discovered exceptionally broad STB resistance in SHs. Subsequent development and analyses of recombinant inbred lines (RILs) from a cross between the SH M3 and the highly susceptible bread wheat cv. Kulm revealed two novel resistance loci on chromosomes 3D and 5A. The 3D resistance was expressed in the seedling and adult plant stages, and it controlled necrosis (N) and pycnidia (P) development as well as the latency periods of these parameters. This locus, which is closely linked to the microsatellite marker Xgwm494, was tentatively designated Stb16q and explained from 41 to 71% of the phenotypic variation at seedling stage and 28–31% in mature plants. The resistance locus on chromosome 5A was specifically expressed in the adult plant stage, associated with SSR marker Xhbg247, explained 12–32% of the variation in disease, was designated Stb17, and is the first unambiguously identified and named QTL for adult plant resistance to M. graminicola. Our results confirm that common wheat progenitors might be a rich source of new Stb resistance genes/QTLs that can be deployed in commercial breeding programs
Defense suppression benefits herbivores that have a monopoly on their feeding site but can backfire within natural communities
Signal transduction underlying the control of urinary bladder smooth muscle tone by muscarinic receptors and β-adrenoceptors
The normal physiological contraction of the urinary bladder, which is required for voiding, is predominantly mediated by muscarinic receptors, primarily the M3 subtype, with the M2 subtype providing a secondary backup role. Bladder relaxation, which is required for urine storage, is mediated by β-adrenoceptors, in most species involving a strong β3-component. An excessive stimulation of contraction or a reduced relaxation of the detrusor smooth muscle during the storage phase of the micturition cycle may contribute to bladder dysfunction known as the overactive bladder. Therefore, interference with the signal transduction of these receptors may be a viable approach to develop drugs for the treatment of overactive bladder. The prototypical signaling pathway of M3 receptors is activation of phospholipase C (PLC), and this pathway is also activated in the bladder. Nevertheless, PLC apparently contributes only in a very minor way to bladder contraction. Rather, muscarinic-receptor-mediated bladder contraction involves voltage-operated Ca2+ channels and Rho kinase. The prototypical signaling pathway of β-adrenoceptors is an activation of adenylyl cyclase with the subsequent formation of cAMP. Nevertheless, cAMP apparently contributes in a minor way only to β-adrenoceptor-mediated bladder relaxation. BKCa channels may play a greater role in β-adrenoceptor-mediated bladder relaxation. We conclude that apart from muscarinic receptor antagonists and β-adrenoceptor agonists, inhibitors of Rho kinase and activators of BKCa channels may have potential to treat an overactive bladder
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