High precision quantum control of single donor spins in silicon

The Stark shift of the hyperfine coupling constant is investigated for a P donor in Si far below the ionization regime in the presence of interfaces using Tight-binding and Band Minima Basis approaches and compared to the recent precision measurements. The TB electronic structure calculations included over 3 million atoms. In contrast to previous effective mass based results, the quadratic Stark coefficient obtained from both theories agrees closely with the experiments. This work represents the most sensitive and precise comparison between theory and experiment for single donor spin control. It is also shown that there is a significant linear Stark effect for an impurity near the interface, whereas, far from the interface, the quadratic Stark effect dominates. Such precise control of single donor spin states is required particularly in quantum computing applications of single donor electronics, which forms the driving motivation of this work.Comment: 5 pages, 2 figure

Mitigating impacts of the COVID-19 pandemic on primary and lower secondary children during school closures: a rapid evidence review

BACKGROUND: To control the spread of the SARS-CoV-2 virus during the COVID-19 pandemic, UK schools were closed and education activity was undertaken at home resulting in considerable disruption to children’s education. AIMS: To identify and assess evidence of harms caused to primary and lower secondary pupils during this time and identify mitigation strategies relevant to those harms. METHODS: A rapid evidence review tailored to delivery at pace, drawing on UK evidence for harms and relevant mitigation strategies. FINDINGS ON HARM: There is evidence that the patterns of disruption to education during the pandemic have impacted on children’s learning and attainment, mental health and wellbeing, physical health and nutrition and increased exposure to risk especially for those children living in potentially dangerous domestic settings. Although the quality of the evidence is uneven, it is clear that children living in poverty have been most affected, in particular through food insecurity and conditions triggering stress and anxiety in the home, alongside their more limited opportunities to access digital resources for learning, or indeed outside space for physical activity. Attempts to distinguish harms that impact in the short term from longer lasting harms may take time. It also requires schools to have access to contextually relevant diagnostic tools they can use to assess the range of harms in need of redress in their local context. FINDINGS ON MITIGATION STRATEGIES: We found no evidence for mitigation strategies directly relevant to the harms experienced by children due to school closures under COVID-19. Mitigation strategies suggested in the UK often derived their evidence of efficacy from circumstances quite unlike the prolonged patterns of disruption to education that COVID has caused. Most were designed to address the needs of a few pupils struggling under normal circumstances and were not able to demonstrate their relevance at scale. We therefore examined the primary literature on recovery from unplanned school closures in other countries focused on school-based strategies that had been evaluated as effective under similar conditions. CONCLUSION: We found some evidence of a range of harms but little research evidence on relevant mitigation strategies and an absence of evidence on those strategies that schools themselves have adopted since re-opening, tailored to local needs. Such mitigation strategies may be highly relevant for system learning, and it is important to document and evaluate their efficacy, and indeed learn from them. Closing schools during the pandemic has revealed the importance of schools in safeguarding children. School staff should be given the training and resources to be able to identify children at risk and refer pupils to appropriate services if necessary

Multiwavelength Observations of a Flare from Markarian 501

We present multiwavelength observations of the BL Lacertae object Markarian 501 (Mrk 501) in 1997 between April 8 and April 19. Evidence of correlated variability is seen in very high energy (VHE, E > 350 GeV) gamma-ray observations taken with the Whipple Observatory gamma-ray telescope, data from the Oriented Scintillation Spectrometer Experiment of the Compton Gamma-Ray Observatory, and quicklook results from the All-Sky Monitor of the Rossi X-ray Timing Explorer while the Energetic Gamma-Ray Experiment Telescope did not detect Mrk 501. Short term optical correlations are not conclusive but the U-band flux observed with the 1.2m telescope of the Whipple Observatory was 10% higher than in March. The average energy output of Mrk 501 appears to peak in the 2 keV to 100 keV range suggesting an extension of the synchrotron emission to at least 100 keV, the highest observed in a blazar and ~100 times higher than that seen in the other TeV-emitting BL Lac object, Mrk 421. The VHE gamma-ray flux observed during this period is the highest ever detected from this object. The VHE gamma-ray energy output is somewhat lower than the 2-100 keV range but the variability amplitude is larger. The correlations seen here do not require relativistic beaming of the emission unless the VHE spectrum extends to >5 TeV.Comment: 10 pages, 2 figures, accepted for publication in ApJ Letter

Very High Energy gamma-ray observations of Mrk 501 using TACTIC imaging gamma-ray telescope during 2005-06

In this paper we report on the Markarian 501 results obtained during our TeV $\gamma$-ray observations from March 11 to May 12, 2005 and February 28 to May 7, 2006 for 112.5 hours with the TACTIC $\gamma$-ray telescope. During 2005 observations for 45.7 hours, the source was found to be in a low state and we have placed an upper limit of 4.62 $\times$ 10$^{-12}$ photons cm$^{-2}$ s$^{-1}$ at 3$\sigma$ level on the integrated TeV $\gamma$-ray flux above 1 TeV from the source direction. However, during the 2006 observations for 66.8h, detailed data analysis revealed the presence of a TeV $\gamma$-ray signal from the source with a statistical significance of 7.5$\sigma$ above $E_{\gamma}\geq$ 1 TeV. The time averaged differential energy spectrum of the source in the energy range 1-11 TeV is found to match well with the power law function of the form ($d\Phi/dE=f_0 E^{-\Gamma}$) with $f_0=(1.66\pm0.52)\times 10^{-11}cm^{-2}s^{-1}TeV^{-1}$ and $\Gamma=2.80\pm0.27$.Comment: 16 pages and 8 Figures Accepted for publication in the Journal of Physics

Stochastically Realized Observables for Excitonic Molecular Aggregates

We show that a stochastic approach enables calculations of the optical properties of large 2-dimensional and nanotubular excitonic molecular aggregates. Previous studies of such systems relied on numerically diagonalizing the dense and disordered Frenkel Hamiltonian, which scales approximately as $\mathcal{O}(N^3)$ for $N$ dye molecules. Our approach scales much more efficiently as $\mathcal{O}(N\log(N))$, enabling quick study of systems with a million of coupled molecules on the micron size scale. We calculate several important experimental observable including the optical absorption spectrum and density of states, and develop a stochastic formalism for the participation ratio. Quantitative agreement with traditional matrix diagonalization methods is demonstrated for both small- and intermediate-size systems. The stochastic methodology enables the study of the effects of spatial-correlation in site energies on the optical signatures of large 2D aggregates. Our results demonstrate that stochastic methods present a path forward for screening structural parameters and validating experiments and theoretical predictions in large excitonic aggregates.Comment: 11 pages, 7 figures, as submitted to JP

The purpose of mess in action research: building rigour though a messy turn

Mess and rigour might appear to be strange bedfellows. This paper argues that the purpose of mess is to facilitate a turn towards new constructions of knowing that lead to transformation in practice (an action turn). Engaging in action research - research that can disturb both individual and communally held notions of knowledge for practice - will be messy. Investigations into the 'messy area', the interface between the known and the nearly known, between knowledge in use and tacit knowledge as yet to be useful, reveal the 'messy area' as a vital element for seeing, disrupting, analysing, learning, knowing and changing. It is the place where long-held views shaped by professional knowledge, practical judgement, experience and intuition are seen through other lenses. It is here that reframing takes place and new knowing, which has both theoretical and practical significance, arises: a 'messy turn' takes place

Pharmacologic Inhibition of COX-1 and COX-2 in Influenza A Viral Infection in Mice

BACKGROUND: We previously demonstrated that cyclooxygenase (COX)-1 deficiency results in greater morbidity and inflammation, whereas COX-2 deficiency leads to reduced morbidity, inflammation and mortality in influenza infected mice. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the effects of COX-1 and COX-2 inhibitors in influenza A viral infection. Mice were given a COX-1 inhibitor (SC-560), a COX-2 inhibitor (celecoxib) or no inhibitor beginning 2 weeks prior to influenza A viral infection (200 PFU) and throughout the course of the experiment. Body weight and temperature were measured daily as indicators of morbidity. Animals were sacrificed on days 1 and 4 post-infection and bronchoalveolar lavage (BAL) fluid was collected or daily mortality was recorded up to 2 weeks post-infection. Treatment with SC-560 significantly increased mortality and was associated with profound hypothermia and greater weight loss compared to celecoxib or control groups. On day 4 of infection, BAL fluid cells were modestly elevated in celecoxib treated mice compared to SC-560 or control groups. Viral titres were similar between treatment groups. Levels of TNF-alpha and G-CSF were significantly attenuated in the SC-560 and celecoxib groups versus control and IL-6 levels were significantly lower in BAL fluid of celecoxib treated mice versus control and versus the SC-560 group. The chemokine KC was significantly lower in SC-560 group versus control. CONCLUSIONS/SIGNIFICANCE: Treatment with a COX-1 inhibitor during influenza A viral infection is detrimental to the host whereas inhibition of COX-2 does not significantly modulate disease severity. COX-1 plays a critical role in controlling the thermoregulatory response to influenza A viral infection in mice