53 research outputs found

    Black Studies in 21st Century Higher Education Webinar Video

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    Video, transcript, and promotional materials for a web-based seminar featuring Dr. Sonia Sanchez and Dr. John Bracey discussing Black Studies in 21st century higher education. The Black History Month program was hosted by the University of Maine Black Student Union, co-hosted by the UMaine Alumni Association

    Pharmacologic Inhibition of the TGF-β Type I Receptor Kinase Has Anabolic and Anti-Catabolic Effects on Bone

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    During development, growth factors and hormones cooperate to establish the unique sizes, shapes and material properties of individual bones. Among these, TGF-β has been shown to developmentally regulate bone mass and bone matrix properties. However, the mechanisms that control postnatal skeletal integrity in a dynamic biological and mechanical environment are distinct from those that regulate bone development. In addition, despite advances in understanding the roles of TGF-β signaling in osteoblasts and osteoclasts, the net effects of altered postnatal TGF-β signaling on bone remain unclear. To examine the role of TGF-β in the maintenance of the postnatal skeleton, we evaluated the effects of pharmacological inhibition of the TGF-β type I receptor (TβRI) kinase on bone mass, architecture and material properties. Inhibition of TβRI function increased bone mass and multiple aspects of bone quality, including trabecular bone architecture and macro-mechanical behavior of vertebral bone. TβRI inhibitors achieved these effects by increasing osteoblast differentiation and bone formation, while reducing osteoclast differentiation and bone resorption. Furthermore, they induced the expression of Runx2 and EphB4, which promote osteoblast differentiation, and ephrinB2, which antagonizes osteoclast differentiation. Through these anabolic and anti-catabolic effects, TβRI inhibitors coordinate changes in multiple bone parameters, including bone mass, architecture, matrix mineral concentration and material properties, that collectively increase bone fracture resistance. Therefore, TβRI inhibitors may be effective in treating conditions of skeletal fragility

    Legitimising Emerging Power Diplomacy: an Analysis of Government and Media Discourses on Brazilian Foreign Policy under Lula

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    Swept Under the Rug? A Historiography of Gender and Black Colleges

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    John H. Bracey, Jr.: The Cost of Racism to White America (1999)

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    https://digitalcommons.ric.edu/av_root/1008/thumbnail.jp
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