Spatial and temporal occurrence of bats in the southern North Sea area

Since a few years it is known that bats migrate over sea on a regular basis. As numerous land-based studies have shown that wind turbines can cause high fatality rates amongst bats Rijkswaterstaat started a bat monitoring programme for 2015 and 2016 in order to reduce uncertainties about possible impacts. At the same time Eneco commissioned a bat monitoring programme for 2015 and 2016 as part of the Monitoring and Evaluation Programme (MEP) for the offshore windfarm Luchterduinen. In 2016 Gemini conducted a bat monitoring campaign in windfarm Buitengaats and Wageningen Marine Research executed a bat monitoring programme at Wintershall platform P6-A and offshore research station FINO3 in the same year. The joint monitoring effort included 12 different offshore locations and 5 locations at the coast. The specific aims of these monitoring programmes are an assessment of : 1. The species composition at sea and at the coast. 2. The spatiotemporal pattern of occurrence, including the flight height. 3. The relation between environmental conditions and the occurrence of bats. 4. The function of the Dutch Territorial Sea for bats. The monitoring results at the coast showed that Nathusius’ pipistrelle is very common during both spring and autumn migration, but is also regular throughout the summer. It is also the most frequently recorded species at sea, albeit much less frequently recorded in comparison to the coast. At sea it was recorded from late August until late October (and one observation in November), and –to a lesser extent- from early April until the end of June. There were no records in July until mid-August. The observed pattern of occurrence matches previous offshore monitoring studies in the German and Dutch North Sea

Aerial Measurement of Radioxenon Concentration off the West Coast of Vancouver Island following the Fukushima Reactor Accident

In response to the Fukushima nuclear reactor accident, on March 20th, 2011, Natural Resources Canada conducted aerial radiation surveys over water just off of the west coast of Vancouver Island. Dose-rate levels were found to be consistent with background radiation, however a clear signal due to Xe-133 was observed. Methods to extract Xe-133 count rates from the measured spectra, and to determine the corresponding Xe-133 volumetric concentration, were developed. The measurements indicate that Xe-133 concentrations on average lie in the range of 30 to 70 Bq/m3.Comment: 14 pages, 5 figures, accepted for publication in Journal of Environmental Radioactivit

2018 European Thyroid Association (ETA) Guidelines on the Diagnosis and Management of Central Hypothyroidism

OBJECTIVES: Central hypothyroidism (CeH) is a rare form of hypothyroidism characterized by insufficient thyroid stimulation due to disturbed pituitary and/or hypothalamic functioning. Due to its origin and the whole clinical context, CeH represents a challenging condition in clinical practice as it is characterized by suboptimal accuracy of clinical and biochemical parameters for diagnosis and management. Since no expert consensus or guidance for this condition is currently available, a task force of experts received the commitment from the European Thyroid Association (ETA) to prepare this document based on the principles of clinical evidence. STUDY DESIGN: The task force started to work in February 2017 and after a careful selection of appropriate references (cohort studies, case reports, expert opinions), a preliminary presentation and live discussion during the 2017 ETA meeting, and several revision rounds, has prepared a list of recommendations to support the diagnosis and management of patients with CeH. RESULTS: Due to the particular challenges of this rare condition in the different ages, the target users of this guidance are pediatric and adult endocrinologists. Experts agreed on the need to recognize and treat overt CeH at all ages, whereas treatment of milder forms may be dispensable in the elderly (> 75 years). CONCLUSION: Despite the lack of randomized controlled clinical trials, the experts provide 34 recommendations supported by variable levels of strength that should improve the quality of life of the affected patients and reduce the metabolic and hormonal consequences of inadequate management

Correlated /\c-/\cbar production in e+e- annihilations at sqrt{s}~10.5 GeV

Using 13.6/fb of continuum two-jet e+e- -> ccbar events collected with the CLEO detector, we have searched for baryon number correlations at the primary quark level. We have measured the likelihood for a /\c+ charmed baryon to be produced in the hemisphere opposite a /\c- relative to the likelihood for a /\c+ charmed baryon to be produced opposite an anticharmed meson Dbar; in all cases, the reconstructed hadrons must have momentum greater than 2.3 GeV/c. We find that, given a /\c- (reconstructed in five different decay modes), a /\c+ is observed in the opposite hemisphere (0.72+/-0.11)% of the time (not corrected for efficiency). By contrast, given a Dbar in one hemisphere, a /\c+ is observed in the opposite hemisphere only (0.21+/-0.02)% of the time. Normalized to the total number of either /\c- or Dbar ``tags'', it is therefore 3.52+/-0.45+/-0.42 times more likely to find a /\c+ opposite a /\c- than a Dbar meson. This enhancement is not observed in the JETSET 7.3 e+e- -> ccbar Monte Carlo simulation.Comment: 19 pages, Latex, one figure separat

Bidding for Success? Impacts of the European Capital of Culture Bid

The increasingly multifaceted nature of event impacts makes them even more attractive as a potential solution to a range of urban and regional problems. As a result, competition to stage major cultural and sporting events is intensifying, and the cost of bidding is also rising. Given that such bidding processes only produce one winner, this means that a growing number of disappointed cities have to justify the costs of bidding for major events. In this context, we analyse the bidding process for the European Capital of Culture in the Netherlands (2018) and its impacts on local social structures. In particular the article focuses on the less tangible, non-economic effects of bidding for events, establishing a framework based on network formation, public support for the bidding process and social cohesion. The conclusions point to the key role of sociality and networking for events, which should therefore be developed throughout the bidding process for successful impacts, either the event is won or not

Inducible liver-specific knockdown of protein tyrosine phosphatase 1B improves glucose and lipid homeostasis in adult mice.

AIMS/HYPOTHESIS Protein tyrosine phosphatase 1B (PTP1B) is a key negative regulator of insulin signalling. Hepatic PTP1B deficiency, using the Alb-Cre promoter to drive Ptp1b deletion from birth in mice, improves glucose homeostasis, insulin sensitivity and lipid metabolism. The aim of this study was to investigate the therapeutic potential of decreasing liver PTP1B levels in obese and insulin-resistant adult mice. METHODS Inducible Ptp1b liver-specific knockout mice were generated using SA-Cre-ER(T2) mice crossed with Ptp1b floxed (Ptp1b(fl/fl)) mice. Mice were fed a high-fat diet (HFD) for 12 weeks to induce obesity and insulin resistance. Tamoxifen was administered in the HFD to induce liver-specific deletion of Ptp1b (SA-Ptp1b(-/-) mice). Body weight, glucose homeostasis, lipid homeostasis, serum adipokines, insulin signalling and endoplasmic reticulum (ER) stress were examined. RESULTS Despite no significant change in body weight relative to HFD-fed Ptp1b(fl/fl) control mice, HFD-fed SA-Ptp1b(-/-) mice exhibited a reversal of glucose intolerance as determined by improved glucose and pyruvate tolerance tests, decreased fed and fasting blood glucose and insulin levels, lower HOMA of insulin resistance, circulating leptin, serum and liver triacylglycerols, serum NEFA and decreased HFD-induced ER stress. This was associated with decreased glycogen synthase, eukaryotic translation initiation factor-2α kinase 3, eukaryotic initiation factor 2α and c-Jun NH2-terminal kinase 2 phosphorylation, and decreased expression of Pepck. CONCLUSIONS/INTERPRETATION Inducible liver-specific PTP1B knockdown reverses glucose intolerance and improves lipid homeostasis in HFD-fed obese and insulin-resistant adult mice. This suggests that knockdown of liver PTP1B in individuals who are already obese/insulin resistant may have relatively rapid, beneficial therapeutic effects

Measurement of B(/\c->pKpi)

The /\c->pKpi yield has been measured in a sample of two-jet continuum events containing a both an anticharm tag (Dbar) as well as an antiproton (e+e- -> Dbar pbar X), with the antiproton in the hemisphere opposite the Dbar. Under the hypothesis that such selection criteria tag e+e- -> Dbar pbar (/\c) X events, the /\c->pkpi branching fraction can be determined by measuring the pkpi yield in the same hemisphere as the antiprotons in our Dbar pbar X sample. Combining our results from three independent types of anticharm tags, we obtain B(/\c->pKpi)=(5.0+/-0.5+/-1.2)

Optimising the future Belgian offshore wind farm monitoring programme

Six years of monitoring triggered a reflection on how to best continue with the monitoring programme. The basic monitoring has to be rationalised at the level of the likelihood of impact detection, the meaningfulness of impact size and representativeness of the findings. Targeted monitoring should continue to disentangle processes behind the observed impact, for instance the overarching artificial reef effect created by wind farms. The major challenge however remains to achieve a reliable assessment of the cumulative impacts. Continuing consultation and collaboration within the Belgian offshore wind farm monitoring team and with foreign marine scientists and managers will ensure an optimisation of the future monitoring programme