Red alert: labile heme is an alarmin

This publication hasn't any creative commons license associated.This deposit is composed by the main article, and it hasn't any supplementary materials associated. There is no public supplementary material available.The deposited article is a pre-print version.Alarmins are a heterogeneous group of endogenous molecules that signal cellular damage when sensed extracellularly. Heme is an endogenous molecule that acts as a prosthetic group of hemoproteins, such as hemoglobin and myoglobin. When released from damaged red blood cells or muscle cells, oxidized hemoglobin and myoglobin release their prosthetic heme groups, respectively. This generates labile heme, which is sensed by pattern recognition receptors (PRR) expressed by innate immune cells and possibly regulatory T cells (TREG). The ensuing adaptive response, which alerts for the occurrence of red blood cell or muscle cell damage, regulates the pathologic outcome of hemolysis or rhabdomyolysis, respectively. In conclusion, we propose that labile heme is an alarmin.Fundação para a Ciência e Tecnologia grants: (PTDC/SAU TOX/116627/2010, HMSP-ICT/0022/2010, RECI/IMI-IMU/0038/2012); Fundação de Amparo a Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Pesquisa, INCTDengue, Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior.info:eu-repo/semantics/publishedVersio

Paradise revealed: first-class science rocked by the sound of the waves

Univ São Paulo, Inst Ciencias Biomed, Dept Imunol, BR-05508900 São Paulo, BrazilInst Nacl Ciencia & Tecnol, Inst Invest Imunol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Ciencias Biol, Diaderna, SP, BrazilFundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Imunofarmacol, Rio de Janeiro, BrazilUniv São Paulo, Fac Med, BR-05508900 São Paulo, BrazilInst Nacl Canc, Div Biol Celular, Rio de Janeiro, BrazilUniversidade Federal de São Paulo, Dept Ciencias Biol, Diaderna, SP, BrazilWeb of Scienc

Particle motion and gravitational lensing in the metric of a dilaton black hole in a de Sitter universe

We consider the metric exterior to a charged dilaton black hole in a de Sitter universe. We study the motion of a test particle in this metric. Conserved quantities are identified and the Hamilton-Jacobi method is employed for the solutions of the equations of motion. At large distances from the black hole the Hubble expansion of the universe modifies the effective potential such that bound orbits could exist up to an upper limit of the angular momentum per mass for the orbiting test particle. We then study the phenomenon of strong field gravitational lensing by these black holes by extending the standard formalism of strong lensing to the non-asymptotically flat dilaton-de Sitter metric. Expressions for the various lensing quantities are obtained in terms of the metric coefficients.Comment: 8 pages, RevTex, 1 eps figures; discussion improved; typos corrected; references adde

Strong Gravitational Lensing in a Charged Squashed Kaluza- Klein Black hole

In this paper we investigate the strong gravitational lensing in a charged squashed Kaluza-Klein black hole. We suppose that the supermassive black hole in the galaxy center can be considered by a charged squashed Kaluza-Klein black hole and then we study the strong gravitational lensing theory and estimate the numerical values for parameters and observables of it. We explore the effects of the scale of extra dimension $\rho_0$ and the charge of black hole $\rho_q$ on these parameters and observables.Comment: 17 pages, 10 figure

Lorentz-violation and cosmological perturbations: a toy brane-world model

We study possible effects of Lorentz-violation on the generation of cosmological perturbations at inflation by introducing a simple inflating five-dimensional brane-world setup with violation of four-dimensional Lorentz-invariance at an energy scale $k$. We consider massless scalar field, meant to mimic perturbations of inflaton and/or gravitational field, in this background. At three-momenta below $k$, there exists a zero mode localized on the brane, whose behaviour coincides with that in four-dimensional theory. On the contrary, at three-momenta above $k$, the localized mode is absent and physics is entirely five-dimensional. As three-momenta get redshifted, more modes get localized on the brane, the phenomenon analogous to ``mode generation''. We find that for $k\gg H$, where $H$ is the inflationary Hubble scale, the spectrum of perturbations coincides with that in four-dimensional theory. For $k < H$ and time-dependent bulk parameters, the spectrum deviates, possibly strongly, from the flat spectrum even for pure de Sitter inflation.Comment: 5 figures, iopart, minor changes, appendix adde

Gravitational Lensing by Black Holes

We review the theoretical aspects of gravitational lensing by black holes, and discuss the perspectives for realistic observations. We will first treat lensing by spherically symmetric black holes, in which the formation of infinite sequences of higher order images emerges in the clearest way. We will then consider the effects of the spin of the black hole, with the formation of giant higher order caustics and multiple images. Finally, we will consider the perspectives for observations of black hole lensing, from the detection of secondary images of stellar sources and spots on the accretion disk to the interpretation of iron K-lines and direct imaging of the shadow of the black hole.Comment: Invited article for the GRG special issue on lensing (P. Jetzer, Y. Mellier and V. Perlick Eds.). 31 pages, 12 figure

Gravitational lensing by stars with angular momentum

Gravitational lensing by spinning stars, approximated as homogeneous spheres, is discussed in the weak field limit. Dragging of inertial frames, induced by angular momentum of the deflector, breaks spherical symmetry. I examine how the gravito-magnetic field affects image positions, caustics and critical curves. Distortion in microlensing-induced light curves is also considered.Comment: 9 pages, 9 figures; to appear in MNRA

Tracking Curvaton(s)?

The ratio of the curvaton energy density to that of the dominant component of the background sources may be constant during a significant period in the evolution of the Universe. The possibility of having tracking curvatons, whose decay occurs prior to the nucleosynthesis epoch, is studied. It is argued that the tracking curvaton dynamics is disfavoured since the value of the curvature perturbations prior to curvaton decay is smaller than the value required by observations. It is also argued, in a related context, that the minimal inflationary curvature scale compatible with the curvaton paradigm may be lowered in the case of low-scale quintessential inflation.Comment: 20 pages, 4figure

Black holes from high-energy beam--beam collisions

Using a recent technique, proposed by Eardley and Giddings, we extend their results to the high-energy collision of two beams of massless particles, i.e. of two finite-front shock waves. Closed (marginally) trapped surfaces can be determined analytically in several cases even for collisions at non-vanishing impact parameter in D\ge 4 space-time dimensions. We are able to confirm and extend earlier conjectures by Yurtsever, and to deal with arbitrary axisymmetric profiles, including an amusing case of ``fractal'' beams. We finally discuss some implications of our results in high-energy experiments and in cosmology.Comment: 17 pages Revtex, 1 figure, references adde

The Primordial Perturbation Spectrum from Various Expanding and Contracting Phases

In this paper, focusing on the case of single scalar field, we discuss various expanding and contracting phases generating primordial perturbations, and study the relation between the primordial perturbation spectrum from these phases and the parameter w of state equation in details. Furthermore, we offer an interesting classification for the primordial perturbation spectrum from various phases, which may have important implications for building an early universe scenario embedded in possible high energy theories.Comment: 5 pages, 3 eps figure