Fungal Surface and Innate Immune Recognition of Filamentous Fungi

The innate immune system performs specific detection of molecules from infectious agents through pattern recognition receptors. This recognition triggers inflammatory responses and activation of microbicidal mechanisms by leukocytes. Infections caused by filamentous fungi have increased in incidence and represent an important cause of mortality and morbidity especially in individuals with immunosuppression. This review will discuss the innate immune recognition of filamentous fungi molecules and its importance to infection control and disease

Tracking Curvaton(s)?

The ratio of the curvaton energy density to that of the dominant component of the background sources may be constant during a significant period in the evolution of the Universe. The possibility of having tracking curvatons, whose decay occurs prior to the nucleosynthesis epoch, is studied. It is argued that the tracking curvaton dynamics is disfavoured since the value of the curvature perturbations prior to curvaton decay is smaller than the value required by observations. It is also argued, in a related context, that the minimal inflationary curvature scale compatible with the curvaton paradigm may be lowered in the case of low-scale quintessential inflation.Comment: 20 pages, 4figure

Gravitational Lensing by Black Holes

We review the theoretical aspects of gravitational lensing by black holes, and discuss the perspectives for realistic observations. We will first treat lensing by spherically symmetric black holes, in which the formation of infinite sequences of higher order images emerges in the clearest way. We will then consider the effects of the spin of the black hole, with the formation of giant higher order caustics and multiple images. Finally, we will consider the perspectives for observations of black hole lensing, from the detection of secondary images of stellar sources and spots on the accretion disk to the interpretation of iron K-lines and direct imaging of the shadow of the black hole.Comment: Invited article for the GRG special issue on lensing (P. Jetzer, Y. Mellier and V. Perlick Eds.). 31 pages, 12 figure

Macrophage Migration Inhibitory Factor in Protozoan Infections

Macrophage migration inhibitory factor (MIF) is a cytokine that plays a central role in immune and inflammatory responses. In the present paper, we discussed the participation of MIF in the immune response to protozoan parasite infections. As a general trend, MIF participates in the control of parasite burden at the expense of promoting tissue damage due to increased inflammation

Gravitational lensing by stars with angular momentum

Gravitational lensing by spinning stars, approximated as homogeneous spheres, is discussed in the weak field limit. Dragging of inertial frames, induced by angular momentum of the deflector, breaks spherical symmetry. I examine how the gravito-magnetic field affects image positions, caustics and critical curves. Distortion in microlensing-induced light curves is also considered.Comment: 9 pages, 9 figures; to appear in MNRA

Computational exploration of molecular receptive fields in the olfactory bulb reveals a glomerulus-centric chemical map

© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Progress in olfactory research is currently hampered by incomplete knowledge about chemical receptive ranges of primary receptors. Moreover, the chemical logic underlying the arrangement of computational units in the olfactory bulb has still not been resolved. We undertook a large-scale approach at characterising molecular receptive ranges (MRRs) of glomeruli in the dorsal olfactory bulb (dOB) innervated by the MOR18-2 olfactory receptor, also known as Olfr78, with human ortholog OR51E2. Guided by an iterative approach that combined biological screening and machine learning, we selected 214 odorants to characterise the response of MOR18-2 and its neighbouring glomeruli. We found that a combination of conventional physico-chemical and vibrational molecular descriptors performed best in predicting glomerular responses using nonlinear Support-Vector Regression. We also discovered several previously unknown odorants activating MOR18-2 glomeruli, and obtained detailed MRRs of MOR18-2 glomeruli and their neighbours. Our results confirm earlier findings that demonstrated tunotopy, that is, glomeruli with similar tuning curves tend to be located in spatial proximity in the dOB. In addition, our results indicate chemotopy, that is, a preference for glomeruli with similar physico-chemical MRR descriptions being located in spatial proximity. Together, these findings suggest the existence of a partial chemical map underlying glomerular arrangement in the dOB. Our methodology that combines machine learning and physiological measurements lights the way towards future high-throughput studies to deorphanise and characterise structure-activity relationships in olfaction.Peer reviewe

Electromagnetic waves around dilatonic stars and naked singularities

We study the propagation of classical electromagnetic waves on the simplest four-dimensional spherically symmetric metric with a dilaton background field. Solutions to the relevant equations are obtained perturbatively in a parameter which measures the strength of the dilaton field (hence parameterizes the departure from Schwarzschild geometry). The loss of energy from outgoing modes is estimated as a back-scattering process against the dilaton background, which would affect the luminosity of stars with a dilaton field. The radiation emitted by a freely falling point-like source on such a background is also studied by analytical and numerical methods.Comment: 9 pages, 1 figur

Gravitational lensing in the Kerr-Randers optical geometry

A new geometric method to determine the deflection of light in the equatorial plane of the Kerr solution is presented, whose optical geometry is a surface with a Finsler metric of Randers type. Applying the Gauss-Bonnet theorem to a suitable osculating Riemannian manifold, adapted from a construction by Naz\i m, it is shown explicitly how the two leading terms of the asymptotic deflection angle of gravitational lensing can be found in this way.Comment: 7 pages, 1 figure. Accepted by Gen. Rel. Grav. Version 2: change of notation in sec.

Strong Gravitational Lensing in a Charged Squashed Kaluza- Klein Black hole

In this paper we investigate the strong gravitational lensing in a charged squashed Kaluza-Klein black hole. We suppose that the supermassive black hole in the galaxy center can be considered by a charged squashed Kaluza-Klein black hole and then we study the strong gravitational lensing theory and estimate the numerical values for parameters and observables of it. We explore the effects of the scale of extra dimension $\rho_0$ and the charge of black hole $\rho_q$ on these parameters and observables.Comment: 17 pages, 10 figure